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:: دوره 21، شماره 3 - ( پاییز 1398 ) ::
جلد 21 شماره 3 صفحات 1-12 برگشت به فهرست نسخه ها
شیوع، علل، درمان و عملکرد بیضه قبل و بعد از درمان واریکوسل: مطالعه مروری نظام‌مند
مریم میرچناری1 ، بهزاد عباسی2 ، مرضیه تولائی* 3، لیلا آزادی1 ، محمد حسین نصر اصفهانی4
1- کارشناس ارشد فیزیولوژی، پژوهشگاه رویان، پژوهشکده زیست فناوری جهاد دانشگاهی، مرکز تحقیقات پزشکی تولید مثل، گروه زیست فناوری تولید مثل، اصفهان، ایران
2- دانشجوی رشته پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
3- استادیار، پژوهشگاه رویان، پژوهشکده زیست فناوری جهاد دانشگاهی، مرکز تحقیقات پزشکی تولید مثل، گروه زیست فناوری تولید مثل، اصفهان، ایران ، tavalaee.m@royaninstitute.org
4- استاد، پژوهشگاه رویان، پژوهشکده زیست فناوری جهاد دانشگاهی، مرکز تحقیقات پزشکی تولید مثل، گروه زیست فناوری تولید مثل، اصفهان، ایران. مرکز باروری و ناباروری اصفهان، اصفهان، ایران
چکیده:   (245 مشاهده)
واریکوسل، اختلال در وریدهای بیضه است که با اتساع و پیچش عروق شبکه پامپینی‌فرم یا شبکه وریدی کرماستریک شناخته می‌شود و می‌تواند موجب اختلال در اسپرماتوژنز گردد. شدت واریکوسل با کاهش پتانسیل باروری مردان مرتبط است. این مقاله مروری مکانیسم‌های اثر واریکوسل بر فرآیند اسپرماتوژنز و پتانسیل باروری، اتیولوژی واریکوسل، رویکردهای درمانی و نتایج آنها را مورد بحث قرار می‌دهد. کلیه مطالعات چاپ شده از سال ۱۹۷۹ تا 2018 از بانک‌های اطلاعاتی Science Direct،Google Scholar ،Scopus و Pubmed بر اساس کلید‌واژه‌های ناباروری، واریکوسل، واریکوسلکتومی، اسپرماتوژنز، و نتایج کلینیکی استخراج شد و از این مقاله‌ها، در مجموع ۷۴ مقاله وارد مطالعه گردید. افزایش دمای بیضه، بازگشت متابولیت‌های سمی از کلیه یا غدد فوق کلیه (آدرنال)، هیپوکسی، اختلال هورمونی و تنش اکسایشی (Oxidative stress) از شایع‌ترین علل پاتوژنز واریکوسل است که می‌تواند باعث تغییر عملکرد طبیعی بیضه و اسپرم شود. چندین مطالعه نشان داده‌اند که انجام واریکوسلکتومی می‌تواند باعث بهبود پارامترهای اسپرم، وضعیت کروماتین، و توانایی باروری در افراد نابارور مبتلا به واریکوسل شود. احتمالاً درمان واریکوسل قبل از استفاده از روش‌های کمک‌باروری، می تواند باعث افزایش شانس حاملگی طبیعی در این افراد نابارور گردد.
واژه‌های کلیدی: بیضه، ناباروری، واریکوسل، واریکوسلکتومی، اسپرماتوژنزیس
متن کامل [PDF 337 kb]   (25 دریافت)    
نوع مطالعه: مروري | موضوع مقاله: ارولوژي
* نشانی نویسنده مسئول: اصفهان، پژوهشگاه رویان، پژوهشکده زیست فناوری جهاددانشگاهی، مرکز تحقیقات پزشکی تولید مثل، گروه زیست فناوری تولید مثل، تلفن: 95015682-031
فهرست منابع
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Mirchenari M, Abbasi B, Tavalaee M, Azadi L, Nasr- Esfahani M. Prevalence, etiology, testicular function and clinic outcome before and after varicocelectomy: A systematic review. J Gorgan Univ Med Sci. 2019; 21 (3) :1-12
URL: http://goums.ac.ir/journal/article-1-3439-fa.html

میرچناری مریم، عباسی بهزاد، تولائی مرضیه، آزادی لیلا، نصر اصفهانی محمد حسین. شیوع، علل، درمان و عملکرد بیضه قبل و بعد از درمان واریکوسل: مطالعه مروری نظام‌مند. مجله علمي دانشگاه علوم پزشكي گرگان. 1398; 21 (3) :1-12

URL: http://goums.ac.ir/journal/article-1-3439-fa.html



دوره 21، شماره 3 - ( پاییز 1398 ) برگشت به فهرست نسخه ها
مجله علمی دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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