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:: Volume 21, Issue 3 (10-2019) ::
J Gorgan Univ Med Sci 2019, 21(3): 1-12 Back to browse issues page
Prevalence, etiology, testicular function and clinic outcome before and after varicocelectomy: A systematic review
Maryam Mirchenari1 , Behzad Abbasi2 , Marziyeh Tavalaee 3, Leila Azadi1 , Mohammad-Hossein Nasr- Esfahani4
1- M.Sc in Physiology, Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
2- Medicine Faculty, Isfahan University of Medical Sciences, Isfahan, Iran
3- Assistant Professor, Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran , tavalaee.m@royaninstitute.org
4- Professor, Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. Isfahan Fertility and Infertility Center, Isfahan, Iran
Abstract:   (6097 Views)

Varicocele is a deficiency of the testicular veins which is recognized by elongation and tortuosity of the pampiniform or cremasteric venous plexus and can lead to impaired spermatogenesis. Varicocele intensity is associated with the reduction of male fertility potential. This review article discusses the effects of varicocele on spermatogenesis process and fertility potential, etiology of varicocele, therapeutic approaches, and the result of treatment. All the published papers from 1975 to 2018 from databases bank such as Science Direct, Google Scholar, Scopus, and PubMed with keywords; infertility, varicocele, varicocelectomy, spermatogenesis, clinical outcome were collected and within these papers, only 74 papers were included for this study. Increased of testicular temperature, backflow of toxic metabolites from the kidney or adrenal glands, hypoxia, hormonal disturbances and oxidative stress are the most prevalent pathogenic cause of varicocele that they can alter testis and sperm functions. Several studies show that varicocelectomy can improve sperm parameters, chromatin statue and fertility potential in infertile men with varicocele. Possibly, treatment of varicocele before assisted reproduction technologies could increase the chance of spontaneous pregnancy in these infertile men.

Keywords: Testis, Infertility, Varicocele, Varicocelectomy, Spermatogenesis
Full-Text [PDF 337 kb]   (8656 Downloads)    
Type of Study: Review Article | Subject: Urology
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Mirchenari M, Abbasi B, Tavalaee M, Azadi L, Nasr- Esfahani M. Prevalence, etiology, testicular function and clinic outcome before and after varicocelectomy: A systematic review. J Gorgan Univ Med Sci 2019; 21 (3) :1-12
URL: http://goums.ac.ir/journal/article-1-3439-en.html


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Volume 21, Issue 3 (10-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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