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Comparative Effects of Ginseng Extract and Green Tea with Pomeol Bruler on C-Reactive Protein and Liver Enzymes of Rats Fed a High-Fat Diet
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Mandana Salehi1    , Kahin Shahanipour * 2, Ramesh Monajemi3 , Parisa Mohamadynejad4 |
1- Ph.D Candidate in Biochemistry, Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
2- Assistant Professor, Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran. , shahanipur_k@yahoo.com
3- Assistant Professor, Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
4- Assistant Professor, Department of Biology, ShahreKord Branch, Islamic Azad University, ShahreKord, Iran. |
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Abstract: (2563 Views) |
Background and Objective: Many studies have been done on the effects of ginseng and green tea on inflammatory factors and liver enzymes, but no research has yet studied the comparative effects of ginseng and green tea extracts with Pomeol Breuler on C-reactive protein (CRP) and liver enzymes in hyperlipidemic rats. This study was done to evaluate the effects of ginseng and green tea extracts in comparison with Pomeol Bruler on CRP and liver enzymes in hyperlipidemic rats.
Methods: In this experimental study, 42 male Wistar rats were randomly allocated into 7 groups. Animals in group 1 (control group) received a normal diet. The experimental groups 2-7 received a high-fat diet for a month. The groups were treated with the extract for 8 weeks and by intraperitoneal injection. Groups 1 and 2 received 77.5 mg/kg/day and 155 mg/kg/day green tea extract, respectively. Groups 3 and 4 received 103.3 mg/kg/day and 206.6 mg/kg/day ginseng extract, respectively. Group 5 received 0.16 g/kg/day of Pomeol Bruler, and group 6 received green tea extract (155 mg/kg/day) and ginseng extract (206.6 mg/kg/day). At the end of the treatment, the level of CRP and liver enzymes including aspartate transaminase (AST) and alanine transaminase (ALT) were measured.
Results: The level of CRP was significantly reduced in the rats treated with ginseng, green tea, and Pomeol Bruler compared with the control group (P<0.05). The level of AST and ALT did not differ significantly between the ginseng, green tea, Pomeol Bruler, and control groups.
Conclusion: The combined use of ginseng and green tea with Pomeol Breuler for 8 weeks may reduce inflammatory factors but does not affect liver enzymes.
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Keywords: Ginseng [MeSH], Green Tea Extract [MeSH], C-Reactive Protein [MeSH], Alanine Transaminase [MeSH], Aspartate Transaminase [MeSH]
Article ID: Vol24-17 |
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Full-Text [PDF 488 kb]
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Type of Study: Original Articles |
Subject:
Biochemistry
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1. Wang Z, Nakayama T. Inflammation, a link between obesity and cardiovascular disease. Mediators Inflamm. 2010; 2010: 535918. DOI: 10.1155/2010/535918 [ DOI] [ PubMed] 2. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002 Mar; 105(9): 1135-43. DOI: 10.1161/hc0902.104353 [ DOI] [ PubMed] 3. Kopelman PG. Obesity as a medical problem. Nature. 2000 Apr; 404(6778): 635-43. DOI: 10.1038/35007508 [ DOI] [ PubMed] 4. Bibbins-Domingo K, Chertow GM, Coxson PG, Moran A, Lightwood JM, Pletcher MJ, et al. Projected effect of dietary salt reductions on future cardiovascular disease. N Engl J Med. 2010 Feb; 362(7): 590-99. DOI: 10.1056/NEJMoa0907355 [ DOI] [ PubMed] 5. No authors listed Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health. Obes Res. 1998 Sep; 6(Suppl 2): 51S-209S. [ PubMed] 6. Bojanowska E, Ciosek J. Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior. Curr Neuropharmacol. 2016; 14(2): 118-42. DOI: 10.2174/1570159x14666151109103147 [ DOI] [ PubMed] 7. Yan J, Zhao Y, Zhao B. Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors. Sci China Life Sci. 2013 Sep; 56(9): 804-10. DOI: 10.1007/s11427-013-4512-2 [ DOI] [ PubMed] 8. Crespy V, Williamson G. A review of the health effects of green tea catechins in in vivo animal models. J Nutr. 2004 Dec; 134(12 Suppl): 3431S-3440S. DOI: 10.1093/jn/134.12.3431S [ DOI] [ PubMed] 9. Sano M, Takahashi Y, Yoshino K, Shimoi K, Nakamura Y, Tomita I, et al. Effect of tea (Camellia sinensis L.) on lipid peroxidation in rat liver and kidney: a comparison of green and black tea feeding. Biol Pharm Bull. 1995 Jul; 18(7): 1006-8. DOI: 10.1248/bpb.18.1006 [ DOI] [ PubMed] 10. Park HJ, DiNatale DA, Chung MY, Park YK, Lee JY, Koo SI, et al. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J Nutr Biochem. 2011 Apr; 22(4): 393-400. DOI: 10.1016/j.jnutbio.2010.03.009 [ DOI] [ PubMed] 11. Bursill CA, Abbey M, Roach PD. A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit. Atherosclerosis. 2007 Jul; 193(1): 86-93. DOI: 10.1016/j.atherosclerosis.2006.08.033 [ DOI] [ PubMed] 12. Augustyniak A, Waszkiewicz E, Skrzydlewska E. Preventive action of green tea from changes in the liver antioxidant abilities of different aged rats intoxicated with ethanol. Nutrition. 2005 Sep; 21(9): 925-32. DOI: 10.1016/j.nut.2005.01.006 [ DOI] [ PubMed] 13. Hosseini SH, Amoghli Tabrizi B, Mazlom Mogaddam SSR. Evaluation at Ginseng on Lipid Profiles, Liver and Renal Markers in Diabetic Rats. J Adv Med Biomed Res. 2011; 19(75): 11-17. [ View at Publisher] 14. Calabró P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003 Oct; 108(16): 1930-32. DOI: 10.1161/01.CIR.0000096055.62724.C5 [ DOI] [ PubMed] 15. Senthil Kumaran V, Arulmathi K, Sundarapandiyan R, Kalaiselvi P. Attenuation of the inflammatory changes and lipid anomalies by epigallocatechin-3-gallate in hypercholesterolemic diet fed aged rats. Exp Gerontol. 2009 Dec; 44(12): 745-51. DOI: 10.1016/j.exger.2009.08.010 [ DOI] [ PubMed] 16. Chen LH, Chien YW, Liang CT, Chan CH, Fan MH, Huang HY. Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat. Food Nutr Res. 2017 Jul; 61(1): 1347480. DOI: 10.1080/16546628.2017.1347480 [ DOI] [ PubMed] 17. Ahmadi-Noorbakhsh S. [Sample size calculation for animal studies -with emphasis on the ethical principles of reduction of animal use]. Research in Medicine. 2018; 42(3): 144-53. [Article in Persian] [ View at Publisher] 18. Namita P, Mukesh R, Vijay K. Camellia Sinensis (Green Tea): A Review. Global Journal of Pharmacology. 2012; 6(2): 52-59. [ Article] 19. Peng N, Liu JT, Guo F, Li R. Epigallocatechin-3-gallate inhibits interleukin-6- and angiotensin II-induced production of C-reactive protein in vascular smooth muscle cells. Life Sci. 2010 Mar; 86(11-12): 410-15. DOI: 10.1016/j.lfs.2010.01.010 [ DOI] [ PubMed] 20. Zolfaghary M, Taghian F, Hedayati M. [Comparing the effect of green tea extract consumption, aerobic exercise and combination of these two methods on CRP Level in obese women]. RJMS. 2013; 20 (110): 8-21. [Article in Persian] [ View at Publisher] |
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Salehi M, Shahanipour K, Monajemi R, Mohamadynejad P. Comparative Effects of Ginseng Extract and Green Tea with Pomeol Bruler on C-Reactive Protein and Liver Enzymes of Rats Fed a High-Fat Diet. J Gorgan Univ Med Sci 2022; 24 (2) :19-23 URL: http://goums.ac.ir/journal/article-1-4026-en.html
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