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:: Volume 20, Issue 3 (10-2018) ::
J Gorgan Univ Med Sci 2018, 20(3): 76-81 Back to browse issues page
Anticancer activity of two novel quinoline compounds on human gastric cancer cells
Sayyed Mohammad Aboutorabzadeh Birjand1 , Fatemeh Mosaffa2 , Ali Ghasemi3 , Razieh Ghodsi * 4
1- Pharmacist, Medicinal Chemistry Department, Mashhad University of Medical Sciences, Mashhad, Iran
2- Associate Professor, Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran
3- Associate Professor, Department of Pediatric Hematology and Oncology, University of Medical Sciences, Mashhad, Iran
4- Associate Professor, Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran. ghodsir@mums.ac.ir , ghodsir@mums.ac.ir
Abstract:   (7822 Views)
Background and Objective: Increasing interest has been devoted to the design and discovery of more effective anticancer agents in current medicinal chemistry because of the high prevalence of cancer in different societies and resistance occurrence to existing anticancer drugs. The aim of this study was to evaluate the anticancer activity of two novel quinoline compounds (RQ1 and RQ2) on human gastric cancer cells.
Methods: In this descriptive - analytic study, the anticancer effects of the compounds were evaluated by MTT assay. This test was performed on two categories of gastric cancer cells sensitive to Danorubicin (EPG85-257P) and resistant to Danorubicin (EPG85-257RDB). The arresting mechanism in the G2 / M phase of the cell cycle and the induction of apoptosis by the compounds was investigated using the PI test and flow cytometric analysis.
Results: Novel quinoline derivatives RQ1 and RQ2 showed good anticancer effects on both sensitive and resistant human gastric cancer cells (IC50=25-38mM). Compound RQ2 showed the most cytotoxic activity on the Danorubicin-sensitive cancer cell line with IC50=25mM. The percentage of Danorubicin resistant gastric cancer cells (EPG85-257RDB) in the G2 / M phase at 25mm concentration of RQ1 and RQ2 was 35.95 and 34.88, respectively, and 41.1% and 42.89% of these cells, after treatment with 50mm concentration of RQ1 and RQ2 arrested at the G2 / M phase respectively.
Conclusion: The two novel quinoline compounds, RQ1 and RQ2 showed strong anticancer effect on both sensitive and resistant human gastric cancer cell lines.
Keywords: Cancer, Stomach, Quinoline, Cytotoxicity
Full-Text [PDF 545 kb] [English Abstract]   (13423 Downloads) |   |   Abstract (HTML)  (308 Views)  
Type of Study: Original Articles | Subject: Pharmacology
* Corresponding Author Address: Associate Professor, Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran. ghodsir@mums.ac.ir
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Aboutorabzadeh Birjand S M, Mosaffa F, Ghasemi A, Ghodsi R. Anticancer activity of two novel quinoline compounds on human gastric cancer cells . J Gorgan Univ Med Sci 2018; 20 (3) :76-81
URL: http://goums.ac.ir/journal/article-1-3458-en.html


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Volume 20, Issue 3 (10-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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