[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Aim and Scope
Content Coverage
Ethics
Conflict of Interest
Copyrights & License
Price
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Current Issue
All Issues
Instruction to Authors::
Peer-Review::
Contact Us::
Contact Us
Contact Form
Site Facilities::
Search contents
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 21, Issue 3 (10-2019) ::
J Gorgan Univ Med Sci 2019, 21(3): 24-33 Back to browse issues page
Impact of aerobic and resistance training supplemented with the consumption of saffron on glutathione peroxidase and malondialdehyde in men with type 2 diabetes
Vahid Aghajani1 , Marzieh Nazari2 , Ramin Shabani * 3
1- M.A in Exercise Physiology, Department of Exercise Physiology, Rasht Branch, Islamic Azad University, Guilan, Rasht, Iran
2- Ph.D Candidate in Exercise Physiology, Department of Exercise Physiology, Young Researchers and Elite Club, Rasht Branch, Islamic Azad University, Guilan, Rasht, Iran
3- Associate Professor, Department of Exercise Physiology, Rasht Branch, Islamic Azad University, Guilan, Rasht, Iran , shabani_msn@yahoo.com
Abstract:   (8550 Views)
Background and Objective: Type 2 diabetes is a chronic disease that associated with increased serum glucose and insulin function impairment. Exercise training and saffron supplement are known as two effective factors in the prevention of the complications of type 2 diabetes. The present study aimed to evaluate the impact of eight weeks of aerobic and resistance training with the consumption of saffron aqueous extract on malondialdehyde and glutathione peroxidase in men with type 2 diabetes.
Methods: In this clinical trial study, 36 men suffering from type 2 diabetes were randomly assigned into six groups: placebo, aerobic training, aerobic training with supplement consumption, resistance training, and resistance training with supplement consumption. Aerobic training was performed at 50-70% of maximal heart rate, and the resistance training was performed at 65-70% of the maximum replication for eight weeks. The saffron supplement was consumed at the dosage of 3 mg day-1. The concentration of malondialdehyde and glutathione peroxidase was measured before and after the trial after the 12-hour fasting period.
Results: Level of malondialdehyde significantly reduced in placebo and aerobic training with supplement prior to intervention (P<0.05). Level of glutathione peroxidase were significantly increased in aerobic training with supplement (P<0.05), resistance training (P<0.05) and resistance training with supplement (P<0.05) groups after intervention.
Conclusion: Aerobic and resistance training and their supplementation with saffron consumption can be regarded as an effective method to improve the peroxidase and antioxidant balance.
Keywords: Diabetes mellitus, Oxidative stress, Strength training, Antioxidants, Saffron supplement
Full-Text [PDF 266 kb]   (11417 Downloads)    
Type of Study: Original Articles | Subject: Internal Medicine
References
1. Esteghamati A, Gouya MM, Abbasi M, Delavari A, Alikhani S, Alaedini F, et al. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran. Diabetes Care. 2008 Jan; 31(1): 96-98. doi: 10.2337/dc07-0959
2. Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. Lancet. 2017 Jun; 389(10085): 2239-51. doi: 10.1016/S0140-6736(17)30058-2
3. Aslam F, Iqbal S, Nasir M, Anjum AA. White Sesame Seed Oil Mitigates Blood Glucose Level, Reduces Oxidative Stress, and Improves Biomarkers of Hepatic and Renal Function in Participants with Type 2 Diabetes Mellitus. J Am Coll Nutr. 2019 Mar-Apr; 38(3): 235-46. doi: 10.1080/07315724.2018.1500183
4. Huang JQ, Zhou JC, Wu YY, Ren FZ, Lei XG. Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases. Free Radical Biology and Medicine. 2018; 127: 108-15. https://doi.org/10.1016/j.freeradbiomed.2018.05.077
5. Yasrebi S, Zolfaghari H, Ajabi Farshbaf J, Zolfaghari MR. [The Effects of Sprint Training and Vitamins E and C Supplementation on Plasma GPX, LDL-ox and MDA]. Journal of Cell & Tissue. 2012; 3(3): 221-30. [Article in Persian]
6. Vincent KR, Vincent HK, Braith RW, Lennon SL, Lowenthal DT. Resistance exercise training attenuates exercise-induced lipid peroxidation in the elderly. Eur J Appl Physiol. 2002 Aug; 87(4-5): 416-23. doi: 10.1007/s00421-002-0640-2
7. Fakoori Jouibari M, Farzanegi P, Barari A. [The Effect of 8-week Aerobic Exercise with Purslane Supplementation Consumption on Peroxidant and Antioxidants Indicators in Women with Type 2 Diabetes]. J Shahid Sadoughi Uni Med Sci. 2014; 22(1): 928-39. [Article in Persian]
8. Iborra RT, Ribeiro IC, Neves MQ, Charf AM, Lottenberg SA, Negrão CE, et al. Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus. Scand J Med Sci Sports. 2008 Dec; 18(6): 742-50. doi: 10.1111/j.1600-0838.2007.00748.x
9. Arslan M, Ipekci SH, Kebapcilar L, Dogan Dede N, Kurban S, Erbay E, et al. Effect of Aerobic Exercise Training on MDA and TNF- α Levels in Patients with Type 2 Diabetes Mellitus. International Scholarly Research Notices. Volume 2014, Article ID 820387. http://dx.doi.org/10.1155/2014/820387
10. Hosseini S, Nik bakht H, Azarbayjani M. [The Effect of Aqua Extract of Saffron with Resistance Training on Glycemic Indexes of Streptozotocin Induced Diabetic Rats]. Armaghane Danesh. 2013; 18(4): 284-94. [Article in Persian]
11. Dogan Dede N, Ipekci S, Kebapcilar L, Arslan M, Kurban S, Yildiz M, Gonen MS. Effect of aerobic exercise training on serum malondialdehyde level and quality of life in type 2 diabetes. 20th European Congress of Endocrinology, Barcelona, Spain, 19-22 May 2018. Endocrine Abstracts. 2018; 56: GP100. doi: 10.1530/endoabs.56.GP100
12. Barari A, Shirali S, Amini S, Nazeri-Manzari H. Interactive effect of Saffron extracts and aerobic training on Glutathione Peroxidase (GPX) and Malondialdehyde (MDA) in men with type2 diabetes. J Nutr Sci & Diet. 2017; 3(1): 1-7.
13. Shahrjerd S, Shavandi N, Sheikh-Hoseini R, Shahrjerd S. [The effect of strengthening and endurance training on metabolic factors, quality of life and mental health in women with type П diabetes]. J Shahrekord Univ Med Sci. 2010; 12(3): 85-93. [Article in Persian]
14. National Strength & Conditioning Association (NSCA). NSCA's essentials of personal training. 2nd ed. Champaign: Human Kinetics. 2012.
15. Coskun O, Ocakci A, Bayraktaroglu T, Kanter M. Exercise training prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Tohoku J Exp Med. 2004 Jul; 203(3): 145-54.
16. Hijam D, Rajen S, Premchand Th, Gyaneshwar W. A study on glutathione peroxidase and malondialdehyde in type 2 diabetes. 3rd World Congress on Diabetes & Metabolism. September 24-26, 2012 Marriott Convention Center, Hyderabad, India. J Diabetes Metab. 2012; 3:8. doi: 10.4172/2155-6156.S1.018
17. Piri M. [The Effect of Combination of Saffron Aqueous Extract and Aerobic Exercise on the Concentration of Non-Enzyme Antioxidants in Streptozotocin-Induced Diabetic Rats]. Dissertation. Tehran: Islamic Azad University, Central Tehran Branch. 2012. [Persian]
18. Mohamed Elbalshy M, Elsayed Mohamed M, Fouad Rahma A. Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients. European Journal of Preventive Medicine. 2017; 5(5): 71-76. doi: 10.11648/j.ejpm.20170505.14
19. Nazem F, Farhangi N, Neshat-Gharamaleki M. Beneficial Effects of Endurance Exercise with Rosmarinus officinalis Labiatae Leaves Extract on Blood Antioxidant Enzyme Activities and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats. Can J Diabetes. 2015 Jun; 39(3): 229-34. doi: 10.1016/j.jcjd.2014.11.003
20. Teixeira-Lemos E, Nunes S, Teixeira F, Reis F. Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol. 2011; 10: 12. doi: 10.1186/1475-2840-10-12
21. Moslehi Najafabadi E, Dabidi Roushan VA, Falah Mohammadi Z, Pouramir M. [Effect of Short term vitamin E supplementaion on lipid peroxidation of healthy man after exhaustive exercise in the sea level and moderate altitude]. Olympic. 2008; 16(1): 47-57. [Article in Persian]
22. Hellsten Y, Apple FS, Sjödin B. Effect of sprint cycle training on activities of antioxidant enzymes in human skeletal muscle. J Appl Physiol (1985). 1996 Oct; 81(4): 1484-87.
23. Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della Valle G. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness. 1997 Dec; 37(4): 235-39.
24. Kayatekin BM, Gönenç S, Açikgöz O, Uysal N, Dayi A. Effects of sprint exercise on oxidative stress in skeletal muscle and liver. Eur J Appl Physiol. 2002 Jun; 87(2): 141-44. doi: 10.1007/s00421-002-0607-3
25. Liu JF, Chang WY, Chan KH, Tsai WY, Lin CL, Hsu MC. Blood lipid peroxides and muscle damage increased following intensive resistance training of female weightlifters. Ann N Y Acad Sci. 2005 May; 1042:255-61. dDoi: 10.1196/annals.1338.029
Send email to the article author

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Aghajani V, Nazari M, Shabani R. Impact of aerobic and resistance training supplemented with the consumption of saffron on glutathione peroxidase and malondialdehyde in men with type 2 diabetes. J Gorgan Univ Med Sci 2019; 21 (3) :24-33
URL: http://goums.ac.ir/journal/article-1-3416-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 3 (10-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 36 queries by YEKTAWEB 4660