Volume 4, Issue 2 (10-2016)                   Jorjani Biomed J 2016, 4(2): 1-20 | Back to browse issues page

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khosrojerdi A, Mashayekhi K, Zare Marzouni H. Curcumin (Extracted from Tumeric) and its Therapeutic Effects. Jorjani Biomed J 2016; 4 (2) :1-20
URL: http://goums.ac.ir/jorjanijournal/article-1-471-en.html
1- Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Siences, Tehran, Iran
2- Department of Immunology, Faculty of Medicine, Mashhad University of Medical Siences, Mashhad, Iran.
3- Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (17276 Views)

Background and Objectives:  The application of herbal medicine has been rising in recent years. Therefore, it is logical to revise and revive these traditional drugs while identifying their mechanisms of action can result in developing new treatments for many diseases. Curcumin is the most important component of Turmeric with numerous therapeutic properties. We aimed to review the anti-inflammatory and anti-microbial properties of Curcumin and introduce it as a therapeutic molecule in the present article.

Methods: In this review, 121 articles were selected from authenticated electronic resources and scientific library databases such as Pubmed, Medline, Sciencedirect, WOS, DOAJ, SID, Iranmedex, Magiran and Google Scholar search engine in which Curcumin (Turmeric) had been evaluated as a therapeutic molecule from differeny aspects.

Results: Our findings from the literature revealed that immune responses against infectious and inflammatory factors could be fascilitated by Curcumin. However, the low solubility in water and minimal bioavailability which may lead to poor absorbance from gastrointestinal tract, quick metabolization and elimination from blood circulation are the most important problems during oral consumption.

Conclusion: According to the results of the present review article, Curcumin possesses efficient anti-inflammatory, anti-microbial, anti-viral and anti-parasitic properties. However, the low bioavailability of this substance has limited its treatment properties. Nowadays, several mechanisms have been proposed to increase the bioavailability which can improve its absorption.

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Type of Article: Review Article | Subject: General medicine
Received: 2016/12/26 | Accepted: 2016/12/26 | Published: 2016/12/26

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