1. Preis SR, Massaro JM, Robins SJ, Hoffmann U, Vasan RS, Irlbeck T, et al. Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study.Obesity 2010; 18(11): 2191-8. [
view at publisher] [
DOI] [
Google Scholar]
2. Christian A, Elena G, Jerry LN, Klaus L.Mechanisms by which diabetes increases cardiovascular disease. Drug Discov Today Dis Mech .2007; 4(3): 131-40. [
view at publisher] [
DOI] [
Google Scholar]
3. Paula FMM, Leite NC, Borck PC, Freitas-Dias R, Cnop M, Chacon-Mikahil MPT, Cavaglieri CR, Marchetti P, Boschero AC, Zoppi CC, Eizirik DL. Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis. FASEB J. 2018; 32(3):1524-1536. [
view at publisher] [
DOI] [
Google Scholar]
4. Walther TC, Farese RV. The life of lipid droplets. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2009; 1791(6): 459-66. [
view at publisher] [
DOI] [
Google Scholar]
5. Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr. 2013;64(6):682-686 [
view at publisher] [
DOI] [
Google Scholar]
6. Toklu HZ, Tunali-Akbay T, Erkanli G, Yüksel M, Ercan F, Sener G. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns. 2007;33(7):908-16. [
view at publisher] [
DOI] [
Google Scholar]
7. Abascal K, Yarnell E. The Many Faces of Silybum marianum (Milk Thistle): Part 1 - Treating Cancer and Hyperlipidemia and Restoring Kidney Function. Alternat Complement Ther. 2003; 9(4): 170-5. [
view at publisher] [
DOI] [
Google Scholar]
8. Sobolova L, Skottova N, Vecera R, Urbanek K. Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats. Pharmacol Res. 2006 Feb;53(2):104-12. [
view at publisher] [
DOI] [
Google Scholar]
9. Rahimi N, Marandi SM, Kargarfard M. The effect of eight weeks aquatic training on lipid profile of patients who suffer from type II diabetes. J Isfahan Med Sci 2011; 29(148). [
view at publisher] [
Google Scholar]
10. Shirdel Z MR, Hossein M. Tasire antidiabetic va antilipidemic zanjabil dar rathaye diabeti shode ba alloxanemonohydrate va moghayeseye an ba daruye glibenclamide. Iran J Diabetes Lipid Disord. 2009;9(1):7- 15. [in Persian]. [
Google Scholar]
11. Al-Jiffri O, Al-Sharif FM, El-Kader SM, Ashmawy EM. Weight reduction improves markers of hepatic function and insulin resistance in type-2 diabetic patients with non-alcoholic fatty liver. African health sciences. 2013;13(3):667-72. [
view at publisher] [
DOI] [
Google Scholar]
12. Fritz T, Rosenquist U. Walking for exercise-immediate effect on blood glucose levels in type 2 diabetes. Scand J Prim Health Care 2001;19(1):31-33. [
view at publisher] [
DOI] [
Google Scholar]
13. Akbarpur M, Shoorabeh FF, Fahimi M, Peisbaz S. The Effect of Eight Weeks of Soy Supplementation and Aerobic Exercise on Lipid Profile in Overweight Women with Type 2 Diabetes. Herbal Medicines Journal. 2020 ; 25;4(3). [
view at publisher] [
Google Scholar]
14. American Diabetes Association. Standards of medical care in diabetes-2007. Diabetes care. 2007;30(1):S4-1. [
view at publisher] [
DOI] [
Google Scholar]
15. Leon AS, Sanchez OA. Response of blood lipids to exercise training alone or combined with dietary intervention. Medicine & Science in Sports & Exercise. 2001;33(6):S502-S15. [
DOI] [
Google Scholar]
16. Smart NA, King N, McFarlane JR, Graham PL, Dieberg G. Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis. British journal of sports medicine. 2018 Jul 1;52(13):834-43. [
DOI] [
Google Scholar]
17. American College of Sports Medicine ACSM's resource manual for guidelines for exercise testing and prescription. 7th ed. Philadelphia, PA: Wolters Kluwer Health; 2013. [
Google Scholar]
18. Hassani A, Soleymanian K, Hassan B, Donyaei A. The effect of silymarin supplementation and endurance training on the plasma malondialdehyde (MDA) levels, in sedentary men. Journal of Knowledge & Health 2014;9(2):1-6. [
Google Scholar]
19. Cheung BM, Wat NM, Man Y, Tam S, Cheng C, Leung GM, et al. Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2). American Journal of Hypertension. 2008;21(1):17-22. [
view at publisher] [
DOI] [
Google Scholar]
20. Saghebjoo M, Nezamdoost Z, Ahmadabadi F, Saffari I, Hamidi A. The effect of 12 weeks of aerobic training on serum levels high sensitivity C-reactive protein, tumor necrosis factor-alpha, lipid profile and anthropometric characteristics in middle-age women patients with type 2 diabetes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2018;12(2):163-8. [
view at publisher] [
DOI] [
Google Scholar]
21. Shakil-ur-Rehman S, Karimi H, Gillani SA. Effects of supervised structured aerobic exercise training program on high and low density lipoprotein in patients with type II diabetes mellitus. Pak J Med Sci. 2017; 33(1): 96. [
DOI] [
PubMed] [
Google Scholar]
22. Adogu P, Meludu S, Modebe I, Ubajaka C. Albumin and lipid profiles following treadmill exercise among student volunteers of Nnamdi Azikiwe University, Nnewi, Nigeria. Open J Prev Med. 2015; 5(06): 227. [
view at publisher] [
Google Scholar]
23. Lade CG, Marins JC, Lima LM, Carvalho CJ, Teixeira RB, Albuquerque MR, et al. Effects of different exercise programs and minimal detectable changes in hemoglobin A1c in patients with type 2 diabetes. Diabetol Metab Syndr 2016;8 (1):13. [
view at publisher] [
DOI] [
Google Scholar]
24. Delevatti R, Marson E, & Fernando Kruel L. Effect of Aquatic Exercise Training on Lipids Profile and Glycaemia: A Systematic Review. Rev Andal Med Deporte. 2015; 8 (4): 163- 170. [
DOI] [
Google Scholar]
25. Agosti V,Graziano S, Artiaco L, Sorrentino G. Biological mechanisms of stroke prevention by physical activity in type 2 diabetes. Acta Neurol Scand. 2009; 119(4): 213-23. [
view at publisher] [
DOI] [
Google Scholar]
26. Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among T2Dmellitus patients who received novel dose of Silybum marianum (L.) Gaertn.(silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39-44. [
view at publisher] [
DOI] [
Google Scholar]
27. Giuseppe D, Angela DA, Davide R, Pamela M. Effects of a combination of berberis aristata, silybum marianum and monacolin on lipid profile in subjects at low cardiovascular risk; a double-blind, randomized, placebo-controlled trial. International journal of molecular sciences. 2017;18(2):343 [
view at publisher] [
DOI] [
Google Scholar]
28. lymarin, olibanum, and nettle, a mixed herbal formulation in the treatment of type II diabetes: A randomized, double-blind, placebo-controlled, clinical trial. Journal of evidence-based complementary & alternative medicine. 2017;22(4):603-8. [
view at publisher] [
DOI] [
Google Scholar]
29. Famouri F, Salehi MM, Rostampour N, Hashemi E, Shahsanaee A. The effect of silymarin on non-alcoholic fatty liver disease of children. Journal of Herbmed Pharmacology. 2016;6(1):16-20. [
view at publisher] [
Google Scholar]
30. Mohammadi H, Hadi A, Arab A, Moradi S, Rouhani MH. Effects of silymarin supplementation on blood lipids: A systematic review and meta‐analysis of clinical trials. Phytotherapy Research. 2019;33(4):871-80. [
view at publisher] [
DOI] [
Google Scholar]
31. Mohammadi SM, Afkhami Ardacani M, Salami MS, Bolurani S. Effects of silymarin on insulin resistance and blood lipid profile in first-degree relatives of type 2 diabetic patients. Journal of Medicinal Plants. 2013;2(46):170-6. [
view at publisher] [
Google Scholar]
32. Skottová N, Krečman V. Silymarin as a potential hypocholesterolaemic drug. Physiol. Res. 1998;47:1-7. [
Google Scholar]
33. Taylor, F., Huffman, M. D., Macedo, A. F., Moore, T. H. M., Burke, M.,Davey Smith, G., Ebrahim, S. (2013). Statins for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, 31(1), CD004816. [
view at publisher] [
DOI] [
Google Scholar]
34. Choi EJ, Kim EK, Jeoung NH, Kim SH. Effect of silymarin on gluconeogenesis and lactate production in exercising rats. Food science and biotechnology. 2016;25(1):119-24. [
DOI] [
Google Scholar]