Volume 7, Issue 2 (7-2019)
Jorjani Biomed J 2019, 7(2): 71-76 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rahmati M, Mobarra N, Ghannadan H. Oxidative Stress Balance as a diagnostic marker in Stroke. Jorjani Biomed J 2019; 7 (2) :71-76
URL: http://goums.ac.ir/jorjanijournal/article-1-661-en.html
URL: http://goums.ac.ir/jorjanijournal/article-1-661-en.html
1- Metabolic Disorders Research Center, Department of Biochemistry, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,MobarraN@mums.ac.ir
3- Department of Neurology, Golestan University of Medical Sciences, Gorgan, Iran
2- Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ,
3- Department of Neurology, Golestan University of Medical Sciences, Gorgan, Iran
Abstract: (4860 Views)
Background and objectives: Ischemic stroke (IS) is a life-threatening disease which lacks reliable prognostic and/or diagnostic biomarkers. In the present study, we examined the serum oxidative stress balance (OSB) and evaluated its diagnostic and prognostic value for IS.
Methods: Sera from 52 IS patients and 52 sex- and age-matched healthy volunteers were obtained. All patients were subjected to the collection of samples at the time of admission, 24 and 48 hours later, at the time of discharge and three months later. OSB levels were assessed by spectrophotometry. Statistical analyses for diagnostic accuracy of quantitative measures were performed.
Results: We showed that OSB levels were elevated at the time of admission in comparison to normal subjects. ROC curve analysis expressed that OSB could be an acceptable diagnostic marker to discriminate IS patients from normal subjects (AUC = 0.7337; P<0.0001). Kaplan-Meier survival analysis showed that OSB had no prognostic value (P=0.8584).
Conclusion: Oxidative stress balance could be introduced as a suggested biomarker to segregate IS patients from normal subjects.
Methods: Sera from 52 IS patients and 52 sex- and age-matched healthy volunteers were obtained. All patients were subjected to the collection of samples at the time of admission, 24 and 48 hours later, at the time of discharge and three months later. OSB levels were assessed by spectrophotometry. Statistical analyses for diagnostic accuracy of quantitative measures were performed.
Results: We showed that OSB levels were elevated at the time of admission in comparison to normal subjects. ROC curve analysis expressed that OSB could be an acceptable diagnostic marker to discriminate IS patients from normal subjects (AUC = 0.7337; P<0.0001). Kaplan-Meier survival analysis showed that OSB had no prognostic value (P=0.8584).
Conclusion: Oxidative stress balance could be introduced as a suggested biomarker to segregate IS patients from normal subjects.
Type of Article: Original article |
Subject:
Basic Medical Sciences
Received: 2019/03/5 | Accepted: 2019/06/5 | Published: 2019/07/1
Received: 2019/03/5 | Accepted: 2019/06/5 | Published: 2019/07/1
References
1. He J, Klag MJ, Wu Z, Whelton PK (1995) Stroke in the People's Republic of China. I. Geographic variations in incidence and risk factors. Stroke 26 (12):2222-2227 [DOI] [Google Scholar]
2. Shirley R, Ord EN, Work LM (2014) Oxidative Stress and the Use of Antioxidants in Stroke. Antioxidants (Basel, Switzerland) 3 (3):472-501. [DOI] [Google Scholar]
3. Goldstein LB, Adams R, Becker K, Furberg CD, Gorelick PB, Hademenos G, Hill M, Howard G, Howard VJ, Jacobs B, Levine SR, Mosca L, Sacco RL, Sherman DG, Wolf PA, del Zoppo GJ (2001) Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 32 (1):280-299 [DOI] [Google Scholar]
4. Vijayan M, Reddy PH (2016) Peripheral biomarkers of stroke: Focus on circulatory microRNAs. Biochimica et biophysica acta 1862 (10):1984-1993. [DOI] [Google Scholar]
5. Cherubini A, Polidori MC, Bregnocchi M, Pezzuto S, Cecchetti R, Ingegni T, di Iorio A, Senin U, Mecocci P (2000) Antioxidant profile and early outcome in stroke patients. Stroke 31 (10):2295-2300 [DOI] [Google Scholar]
6. Aygul R, Demircan B, Erdem F, Ulvi H, Yildirim A, Demirbas F (2005) Plasma values of oxidants and antioxidants in acute brain hemorrhage: role of free radicals in the development of brain injury. Biological trace element research 108 (1-3):43-52. [DOI] [Google Scholar]
7. Parizadeh MR, Azarpazhooh MR, Mobarra N, Nematy M, Alamdari DH, Tavalaie S, Sahebkar A, Hassankhani B, Ferns G, Ghayour-Mobarhan M (2011) Prooxidant-antioxidant balance in stroke patients and 6-month prognosis. Clinical laboratory 57 (3-4):183-191 [Google Scholar]
8. Rodrigo R, Fernandez-Gajardo R, Gutierrez R, Matamala JM, Carrasco R, Miranda-Merchak A, Feuerhake W (2013) Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS & neurological disorders drug targets 12 (5):698-714. [DOI] [Google Scholar]
9. Jena I, Nayak SR, Behera S, Singh B, Ray S, Jena D, Singh S, Sahoo SK (2017) Evaluation of ischemia-modified albumin, oxidative stress, and antioxidant status in acute ischemic stroke patients. Journal of natural science, biology, and medicine 8 (1):110-113. [DOI] [Google Scholar]
10. Shoeibi A, Razmi N, Ghabeli Juibary A, Hashemy SI (2017) The Evaluation and Comparison of Oxidative Stress in Hemorrhagic and Ischemic Stroke %J Caspian Journal of Neurological Sciences. 3 (11):206-213. [DOI] [Google Scholar]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
