Pluripotent stem cells as the cells with a capacity for self-renewal and differentiation into various specific
cell types have been highly regarded in regenerative medicine studies. To repair the eye disease damages, the
differentiation into retinal pigment epithelial cells of pluripotent stem cells has gained great importance in
recent decades because the inappropriate function of these cells is the main cause of degenerative diseases such
as the age-related macular degeneration. Millions of people in the world suffer this disease.
To restore the damaged cells and, finally, to improve the vision, numerous studies have been conducted on using
pluripotent stem cells, their differentiation into retinal pigment epithelial cells, and finally, their application
in cell therapy. Based on this, many researchers have attempted to produce highly efficient retinal pigment
epithelial cells, such that they show a proper function after transplant, along with the host cells. In this review
article, the importance and the role of pigment epithelial cells, as well as, the studies on the in vitro production
of these cells were examined
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