Jorjani Biomedicine Journal

Pluripotent stem cells as the cells with a capacity for self-renewal and differentiation into various specific

cell types have been highly regarded in regenerative medicine studies. To repair the eye disease damages, the

differentiation into retinal pigment epithelial cells of pluripotent stem cells has gained great importance in

recent decades because the inappropriate function of these cells is the main cause of degenerative diseases such

as the age-related macular degeneration. Millions of people in the world suffer this disease.

To restore the damaged cells and, finally, to improve the vision, numerous studies have been conducted on using

pluripotent stem cells, their differentiation into retinal pigment epithelial cells, and finally, their application

in cell therapy. Based on this, many researchers have attempted to produce highly efficient retinal pigment

epithelial cells, such that they show a proper function after transplant, along with the host cells. In this review

article, the importance and the role of pigment epithelial cells, as well as, the studies on the in vitro production

of these cells were examined