Volume 9, Issue 5 (Nov,Dec-2015 2015)                   mljgoums 2015, 9(5): 53-59 | Back to browse issues page


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Ghorban M, Karimpour F, Ghaffari M A, Kheirollah A, Saki A. Association of the CETP TaqIB Polymorphism with Coronary Artery Disease in Type 2 Diabetic Patients . mljgoums 2015; 9 (5) :53-59
URL: http://mlj.goums.ac.ir/article-1-807-en.html
1- Hyperlipidemia Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (17978 Views)

Abstract

     Background and Objective: Diabetes mellitus is the most common risk factor for coronary artery disease (CAD). Cholesteryl ester transfer protein (CETP) TaqIB polymorphism is associated with changes in lipid profile and may be a risk factor for CAD in patients with diabetes. This study aimed to evaluate the association of CETP TaqIB polymorphism with CAD in patients with type 2 diabetes.

     Methods: In this case-control study, 292 diabetic patients were divided into two groups based on angiography reports (150 participants with normal angiogram as the control group and 142 participants with more than 50% stenosis of at least one coronary artery as the case group). The CETP TaqIB genotypes were determined by PCR-RFLP analysis. Fasting blood glucose was measured using glucose oxidase and lipid profile (triglycerides, total cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol) by an enzymatic method.

       Results: There was no significant difference in the frequency of genotypes and alleles between the case group and controls (the control group: B1B1, 17.3%; B1B2, 63.3%; and B2B2, 19.3%; the case group: B1B1, 18.3%; B1B2, 64.1%; and B2B2, 17.6%) (P=0.92). In the control group, heterozygous participants (genotype B1B2) had higher levels of cholesterol compared with other genotypes (B1B1 and B2B2). Also, the patients with genotype B1B2 had significantly higher weight (P=0.013).

       Conclusion: There is no significant correlation between CETP TaqIB polymorphism and the increased risk of coronary artery disease in patients with type 2 diabetes.

      Keywords: Cholesterol Ester Transfer Protein, Polymorphism, Diabetes Mellitus, Type 2, Coronary Artery Disease

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Research Article: Original Paper |
Received: 2016/02/9 | Accepted: 2016/02/9 | Published: 2016/02/9 | ePublished: 2016/02/9

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.