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mljgoums 2022, 16(2): 34-40 |
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Hashemi A, soori R, Banitalebi E, Choobineh S. Vascular Senescence and Resistance Exercise Training: Focus on Circulating Endothelial Cell-Derived MicroRNA-92a and Endothelin-1. mljgoums 2022; 16 (2) :34-40
URL: http://mlj.goums.ac.ir/article-1-1351-en.html
URL: http://mlj.goums.ac.ir/article-1-1351-en.html
1- Department of Physical Education, Alborz Campus, University of Tehran, Tehran, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran ,soorirahman@yahoo.com
3- Department of Exercise Physiology, Department of Sport Sciences, Faculty of Literature and Humanities, Shahrekord University, Shahrekord, Iran
4- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran ,
3- Department of Exercise Physiology, Department of Sport Sciences, Faculty of Literature and Humanities, Shahrekord University, Shahrekord, Iran
4- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
Abstract: (3941 Views)
Background and objectives: Vascular senescence refers to specific aging-associated changes in the endothelial cells. The purpose of this study was to investigate effects of 12 weeks of resistance training with elastic bands on circulating endothelial cell-derived microRNA-92a and endothelin-1 (ET-1) in elderly women with osteosarcopenic obesity (OSO).
Methods: In the present randomized clinical trial, 48 elderly women with OSO were randomly divided into a control group (n=22) and an experimental group (n=26). The subjects in the intervention group performed 12 weeks of resistance training with elastic bands three times a week. The participants became familiar with targeted number of repetitions and OMNI-resistance exercise scale to control exercise intensity.
Results: The mean age, body fat percentage, body mass index (BMI), and bone mineral density T-score for the hip and L1-L4 lumbar spine of the subjects were 64.13±3.68 years, 45.4%±6.56, 33.1±3.71 kg/m2, and -1.86±1.42, respectively. After the 12-week resistance training, we observed a significant decrease in serum level of mir-92a in the experimental group compared to the control group (p=0.03). However, there was no significant difference between the study groups in terms of body weight, BMI, body fat percentage, total cholesterol, and ET-1 (p≥0.05).
Conclusion: The 12-week resistance training program seems to modulate and decrease serum mir-92a expression in elderly women with OSO. The lack of a significant change in BMI, body fat percentage, and ET-1 levels following the exercise training might be due to the type and intensity of the exercises.
Methods: In the present randomized clinical trial, 48 elderly women with OSO were randomly divided into a control group (n=22) and an experimental group (n=26). The subjects in the intervention group performed 12 weeks of resistance training with elastic bands three times a week. The participants became familiar with targeted number of repetitions and OMNI-resistance exercise scale to control exercise intensity.
Results: The mean age, body fat percentage, body mass index (BMI), and bone mineral density T-score for the hip and L1-L4 lumbar spine of the subjects were 64.13±3.68 years, 45.4%±6.56, 33.1±3.71 kg/m2, and -1.86±1.42, respectively. After the 12-week resistance training, we observed a significant decrease in serum level of mir-92a in the experimental group compared to the control group (p=0.03). However, there was no significant difference between the study groups in terms of body weight, BMI, body fat percentage, total cholesterol, and ET-1 (p≥0.05).
Conclusion: The 12-week resistance training program seems to modulate and decrease serum mir-92a expression in elderly women with OSO. The lack of a significant change in BMI, body fat percentage, and ET-1 levels following the exercise training might be due to the type and intensity of the exercises.
Keywords: Resistance Training [MeSH], Obesity [MeSH], Sarcopenia [MeSH], Osteoporosis [MeSH], Aged [MeSH], Vascular Stiffness [MeSH]
Research Article: Original Paper |
Subject:
Sport Physiology
Received: 2020/12/16 | Accepted: 2021/02/24 | Published: 2022/03/7 | ePublished: 2022/03/7
Received: 2020/12/16 | Accepted: 2021/02/24 | Published: 2022/03/7 | ePublished: 2022/03/7
References
1. JafariNasabian P, Inglis JE, Kelly OJ, Ilich JZ. Osteosarcopenic obesity in women: impact, prevalence, and management challenges. Int J Womens Health. 2017 Jan 13;9:33-42. [View at Publisher] [DOI:10.2147/IJWH.S106107] [PubMed] [Google Scholar]
2. Ormsbee MJ, Prado CM, Ilich JZ, Purcell S, Siervo M, Folsom A, et al. Osteosarcopenic obesity: the role of bone, muscle, and fat on health. Journal of cachexia, sarcopenia and muscle. 2014; 5(3): 183-92. [View at Publisher] [DOI:10.1007/s13539-014-0146-x] [PubMed] [Google Scholar]
3. Kelly OJ, Gilman JC, Boschiero D, Ilich JZ. Osteosarcopenic obesity: Current knowledge, revised identification criteria and treatment principles. Nutrients. 2019; 11(4): 747. [View at Publisher] [DOI:10.3390/nu11040747] [PubMed] [Google Scholar]
4. Ilich JZ, Gilman JC, Cvijetic S, Boschiero D. Chronic Stress Contributes to Osteosarcopenic Adiposity via Inflammation and Immune Modulation: The Case for More Precise Nutritional Investigation. Nutrients. 2020; 12(4): 989. [View at Publisher] [DOI:10.3390/nu12040989] [PubMed] [Google Scholar]
5. Qin B, Yang H, Xiao B. Role of microRNAs in endothelial inflammation and senescence. Molecular biology reports. 2012; 39(4): 4509-18. [View at Publisher] [DOI:10.1007/s11033-011-1241-0] [PubMed]
6. Lu Y, Thavarajah T, Gu W, Cai J, Xu Q. Impact of miRNA in Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2018; 38(9): e159-e70. [View at Publisher] [DOI:10.1161/ATVBAHA.118.310227] [PubMed] [Google Scholar]
7. Ni Y-Q, Lin X, Zhan J-K, Liu Y-S. Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging. Aging and disease. 2020; 11(1): 164. [View at Publisher] [DOI:10.14336/AD.2019.0402] [PubMed] [Google Scholar]
8. Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. nature. 2020; 579(7798): 270-3. [View at Publisher] [DOI:10.1038/s41586-020-2012-7] [PubMed] [Google Scholar]
9. Huang SW, Ku JW, Lin LF, Liao C-D, Chou LC, Liou TH. Body composition influenced by progressive elastic band resistance exercise of sarcopenic obesity elderly women: a pilot randomized controlled trial. European journal of physical and rehabilitation medicine. 2017;53(4):556-63. [View at Publisher] [DOI:10.23736/S1973-9087.17.04443-4] [PubMed] [Google Scholar]
10. Loyer X, Potteaux Sp, Vion A-Cm, Guérin CL, Boulkroun S, Rautou P-E, et al. Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circulation Research.114(3):434-43. [View at Publisher] [DOI:10.1161/CIRCRESAHA.114.302213] [PubMed] [Google Scholar]
11. Gronek P, Wielinski D, Cyganski P, Rynkiewicz A, Zając A, Maszczyk A, et al. A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism. Aging and disease. 2020;11(2): 327. [DOI:10.14336/AD.2019.0516] [PubMed] [Google Scholar]
12. Li G, Li J, Gao F. Exercise and Cardiovascular Protection. Physical Exercise for Human Health: Springer; 2020. p. 205-16. [View at Publisher] [DOI:10.1007/978-981-15-1792-1_14] [PubMed] [Google Scholar]
13. Cook MD, Heffernan KS, Ranadive S, Woods JA, Fernhall B. Effect of resistance training on biomarkers of vascular function and oxidative stress in young African-American and Caucasian men. Journal of human hypertension. 2013; 27(6): 388-92. [View at Publisher] [DOI:10.1038/jhh.2012.48] [PubMed] [Google Scholar]
14. Williams AD, Ahuja KD, Almond JB, Robertson IK, Ball MJ. Progressive resistance training might improve vascular function in older women but not in older men. Journal of Science and Medicine in Sport. 2013; 16(1): 76-81. [View at Publisher] [DOI:10.1016/j.jsams.2012.05.001] [PubMed] [Google Scholar]
15. Barber JL, Zellars KN, Barringhaus KG, Bouchard C, Spinale FG, Sarzynski MA. The effects of regular exercise on circulating cardiovascular-related microRNAs. Scientific reports. 2019; 9(1): 1-8. [DOI:10.1038/s41598-019-43978-x] [PubMed]
16. Miao W, Bao TH, Han JH, Yin M, Yan Y, Wang WW, et al. Voluntary exercise prior to traumatic brain injury alters miRNA expression in the injured mouse cerebral cortex. Brazilian Journal of Medical and Biological Research. 2015; 48(5): 433-9. [View at Publisher] [DOI:10.1590/1414-431x20144012] [PubMed] [Google Scholar]
17. Boutron I, Altman DG, Moher D, Schulz KF, Ravaud P. CONSORT statement for randomized trials of nonpharmacologic treatments: a 2017 update and a CONSORT extension for nonpharmacologic trial abstracts. Annals of internal medicine. 2017; 167(1): 40-7. [View at Publisher] [DOI:10.7326/M17-0046] [PubMed] [Google Scholar]
18. Liao C-D, Tsauo J-Y, Lin L-F, Huang S-W, Ku J-W, Chou L-C, et al. Effects of elastic resistance exercise on body composition and physical capacity in older women with sarcopenic obesity: A CONSORT-compliant prospective randomized controlled trial. Medicine. 2017;96(23): e7115. [DOI:10.1097/MD.0000000000007115] [PubMed] [Google Scholar]
19. Hita-Contreras F, Martínez-Amat A, Cruz-Díaz D, Pérez-López FR. Osteosarcopenic obesity and fall prevention strategies. Maturitas. 2015;80(2):126-32. [View at Publisher] [DOI:10.1016/j.maturitas.2014.11.009] [PubMed] [Google Scholar]
20. Ilich JZ, Kelly OJ, Inglis JE. Osteosarcopenic obesity syndrome: what is it and how can it be identified and diagnosed? Current gerontology and geriatrics research. 2016;2016. [View at Publisher] [DOI:10.1155/2016/7325973] [PubMed] [Google Scholar]
21. Lagally KM, Robertson RJ. Construct validity of the OMNI resistance exercise scale. The Journal of Strength & Conditioning Research. 2006;20(2):252-6. [DOI:10.1519/00124278-200605000-00003] [PubMed] [Google Scholar]
22. Colado JC, Triplett NT. Effects of a short-term resistance program using elastic bands versus weight machines for sedentary middle-aged women. The Journal of Strength & Conditioning Research. 2008;22(5):1441-8. [View at Publisher] [DOI:10.1519/JSC.0b013e31817ae67a] [PubMed] [Google Scholar]
23. Banitalebi E, Faramarzi M, Ghahfarokhi MM, SavariNikoo F, Soltani N, Bahramzadeh A. Osteosarcopenic obesity markers following elastic band resistance training: a randomized controlled trial. Experimental Gerontology. 2020;135:110884. [View at Publisher] [DOI:10.1016/j.exger.2020.110884] [PubMed] [Google Scholar]
24. Huang Y, Yan Y, Xv W, Qian G, Li C, Zou H, et al. A new insight into the roles of miRNAs in metabolic syndrome. BioMed research international.2018. [View at Publisher] [DOI:10.1155/2018/7372636] [PubMed] [Google Scholar]
25. Icli B, Feinberg MW. MicroRNAs in dysfunctional adipose tissue: cardiovascular implications. Cardiovascular Research.2017; 113(9):1024-34. [View at Publisher] [DOI:10.1093/cvr/cvx098] [PubMed] [Google Scholar]
26. Rong X, Jia L, Hong L, Pan L, Xue X, Zhang C, et al. Serum miR-92a-3p as a new potential biomarker for diagnosis of Kawasaki disease with coronary artery lesions. Journal of cardiovascular translational research. 2017; 10(1): 1-8. [View at Publisher] [DOI:10.1007/s12265-016-9717-x] [PubMed] [Google Scholar]
27. Huang Y, Tang S, Ji-Yan C, Huang C, Li J, Cai AP, et al. Circulating miR-92a expression level in patients with essential hypertension: a potential marker of atherosclerosis. Journal of human hypertension. 2016; 31(3):200-5. [View at Publisher] [DOI:10.1038/jhh.2016.66] [PubMed] [Google Scholar]
28. Arsenio Dos Santos Ruivo JM. The use of miR-92a inhibitor to enhance endothelial progenitor cell-mediated regeneration of injured arteries: UCL (University College London). [View at Publisher] [Google Scholar]
29. Barber JL, Zellars KN, Barringhaus KG, Bouchard C, Spinale FG, Sarzynski MA. The effects of regular exercise on circulating cardiovascular-related microRNAs. Scientific reports. 2019;9(1):1-8. [View at Publisher] [DOI:10.1038/s41598-019-43978-x] [PubMed] [Google Scholar]
30. Párrizas M, Brugnara L, Esteban Y, González-Franquesa A, Canivell S, Murillo S, Gordillo-Bastidas E, Cussó R, Cadefau JA, García-Roves PM, Servitja JM, Novials A. Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention. The Journal of Clinical Endocrinology & Metabolism.100(3):E407-E15. [View at Publisher] [DOI:10.1210/jc.2014-2574] [PubMed] [Google Scholar]
31. Taurino R, Pozzi P, Zanasi T. Facile characterization of polymer fractions from waste electrical and electronic equipment (WEEE) for mechanical recycling. Waste Management.30(12):2601-7. [View at Publisher] [DOI:10.1016/j.wasman.2010.07.014] [PubMed] [Google Scholar]
32. Nielsen S, Åkerström T, Rinnov A, Yfanti C, Scheele C, Pedersen BK, et al. The miRNA plasma signature in response to acute aerobic exercise and endurance training. PloS one. 2014; 9(2): e87308. [View at Publisher] [DOI:10.1371/journal.pone.0087308] [PubMed] [Google Scholar]
33. Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, et al. Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. American Journal of Physiology-Heart and Circulatory Physiology. 2009; 297(1): H425-H32. [View at Publisher] [DOI:10.1152/ajpheart.00689.2008] [PubMed] [Google Scholar]
34. Cabiati M, Sapio A, Salvadori C, Burchielli S, Carlucci L, Mattii L, et al. Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging. Peptides. 2020; 123: 170173. [View at Publisher] [DOI:10.1016/j.peptides.2019.170173] [PubMed] [Google Scholar]
35. Timsina R. Influence of Time of Day and Intermittent Aerobic Exercise on Flow-Mediated Dilation and Plasma ET-1 in Healthy Adults: Miami University; 2020. [View at Publisher] [Google Scholar]
36. Liu D, Yi L, Sheng M, Wang G, Zou Y. The Efficacy of Tai Chi and Qigong Exercises on Blood Pressure and Blood Levels of Nitric Oxide and Endothelin-1 in Patients with Essential Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2020;2020. [View at Publisher] [DOI:10.1155/2020/3267971] [PubMed] [Google Scholar]
37. Amirazodi M, Mehrabi A, Kordestani Z, Habibi H, Divsalar K. The Effect of Eight Weeks of Low Intensity Aerobic Exercise on Serum Levels of VIP and ET-1 Hormones in the Non-Athlete Healthy Elderly Women and Patients with Coronary Artery Disease. Report of Health Care. 2019;5(3):24-32. [Google Scholar]
38. Lu W-A, Kuo C-D. Three months of Tai Chi Chuan exercise can reduce serum triglyceride and endothelin-1 in the elderly. Complementary therapies in clinical practice. 2013;19(4):204-8. [View at Publisher] [DOI:10.1016/j.ctcp.2013.06.007] [PubMed] [Google Scholar]
39. Wang H, Chen AF, Watts SW, Galligan JJ, Fink GD. Endothelin in the splanchnic vascular bed of DOCA-salt hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology. 2005;288(2):H729-H36. [View at Publisher] [DOI:10.1152/ajpheart.00388.2004] [PubMed] [Google Scholar]
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