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:: Volume 23, Issue 2 (7-2021) ::
J Gorgan Univ Med Sci 2021, 23(2): 16-23 Back to browse issues page
Effect of eight weeks of aerobic-resistance training on stromal cell-derived factor-1 and platelet-derived growth factor level in patients with coronary artery bypass grafting: A clinical trial study
Seyed Hadi Seyedi1 , Rambod Khajei 2, Amir Rashidlamir3 , Mohammad Reza Ramezanpour4 , Jamshid Mehrzad5
1- Ph.D Candidate in Sport Physiology, Department of Physical Education and Sport Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
2- Assistant Professor, Department of Physical Education and Sport Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran. , r.khajeie@gmail.com
3- Associate Professor, Department of Exercise Physiology, Faculty of Sport Science, Ferdowsi University of Mashhad, Mashhad, Iran.
4- Associate Professor, Department of Physical Education and Sport Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
5- Assistant Professor, Department of Biochemistry, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
Abstract:   (3021 Views)
Background and Objective: Exercise in cardiac patients after coronary artery bypass grafting (CABG) improves cardiovascular function by increasing the capillary density of the myocardium. Platelet-derived growth factor and stromal cell-derived factor-1 play an important role in angiogenesis and cell proliferation and differentiation. This study was performed to determine the effect of eight weeks of combined training on plasma levels of Platelet-derived growth factor (PDGF) and stromal cell-derived factor-1 (SDF1) in CABG patients.
Methods: In this clinical trial study, 24 patients who underwent coronary artery bypass grafting operation were selected using convenience and purposeful sampling method and randomly divided into two combined training and control groups. Subjects in combined training group were received aerobic and resistance training protocols for eight weeks, three sessions per week. Before and after training program, body composition assessments and blood sampling were performed to measure Platelet-derived growth factor (PDGF) and stromal cell-derived factor-1 (SDF1). ELISA method was used to measure PDGF and SDF1.
Results: The level of PDGF was significantly increased in intervention group in compared to control group (P<0.05). Although the level of SDF1 in the intervention group increased in intervention group in compared to control group; but this increase level of SDF1 was not significant.
Conclusion: This study showed that the eight weeks of combined rehabilitation training can promote desirable physiological adaptations in cardiovascular health by increasing the plasma levels of PDGF.

Keywords: Coronary Artery Bypass [MeSH], Rehabilitation [MeSH], Platelet-Derived Growth Factor [MeSH]
Article ID: Vol23-21
Full-Text [PDF 989 kb]   (10769 Downloads)    
Type of Study: Original Articles | Subject: Exercise Physiology
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Seyedi S H, Khajei R, Rashidlamir A, Ramezanpour M R, Mehrzad J. Effect of eight weeks of aerobic-resistance training on stromal cell-derived factor-1 and platelet-derived growth factor level in patients with coronary artery bypass grafting: A clinical trial study. J Gorgan Univ Med Sci 2021; 23 (2) :16-23
URL: http://goums.ac.ir/journal/article-1-3749-en.html


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Volume 23, Issue 2 (7-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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