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:: Volume 18, Issue 3 (10-2016) ::
J Gorgan Univ Med Sci 2016, 18(3): 135-138 Back to browse issues page
Acute necrotizing encephalopathy childhood: a case report
Z Bagheri1 , SA Hosseini 2
1- Resident of Pediatric, Golestan University of Medical Sciences, Gorgan, Iran.
2- Assistant Professor, Pediatric Neurologist, Neonatal and Children Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran. , parnianah@yahoo.com
Abstract:   (13760 Views)

Acute necrotizing encephalopathy (ANEC) is a rare illness with high incidence in East Asia. It is accompanied with respiratory infection, gastrointestinal infections, and high fever with quick impaired consciousness, and convulsion. In this case report, Turkmen 6 month's girl that was introduced after an infection with no disease or clinical abnormalities. She was vaccinated accordingly; initially she had fever with generalized tonic-clonic convulsion (seizures) for 5 to 10 minutes level of consciousness decreased later on. She was transferred to Talghani Medicat Education center in nortern Iran. At the time of admition her vital signs were as below: RR: 30, GCS: 8-9, RP: 110, BP: 90/80. In the patient's history, there was neither Trauma history, nor food or drug poisoning, also no clinical history. After convulsion, the level of consciousness decreased and serum biochemistry showed normal electrolytes concentration. In further follow - up, AST increased to 98 units, ALT to 58 units, and ammonium to 215 units. In CSF Sample, protein level increased to 330 units, without any avidences of pleocytosis, blood, or Serum glucose drop. In CT without contract, hypodensity the cornea in thalamus and caudate cores were seen in 2 sides. The ventricles were normal and there were no signs of bleeding and pressure. In brain M.R.I, abnormal signal in 2 sides, blood samples cultivation, CSF, and testing urine for bacterial infection were negative. The patient was diagnosed with necrotizing encephalopathy and subsequently was treated with metyle prednisolone (20 mg daily). During hospitalization, level of consciousness increased and fever stopped. There was not recurrence of convulsion, but the patients still had some problems in moving, verbal and communication.

Keywords: Encephalopathy, Encephalitis, Epilepsy, Child
Full-Text [PDF 171 kb] [English Abstract]   (13224 Downloads) |   |   Abstract (HTML)  (1062 Views)  
Type of Study: Case Report | Subject: Neurology
References
1. Mizuguchi M, Abe J, Mikkaichi K, Noma S, Yoshida K, Yamanaka T, et al. Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry. 1995 May; 58(5):555-61.
2. Mastroyianni SD, Gionnis D, Voudris K, Skardoutsou A, Mizuguchi M. Acute necrotizing encephalopathy of childhood in non-Asian patients: report of three cases and literature review. J Child Neurol. 2006 Oct; 21(10):872-9. doi:10.1177/ 08830738060210101401
3. Marco EJ, Anderson JE, Neilson DE, Strober JB. Acute necrotizing encephalopathy in 3 brothers. Pediatrics. 2010 Mar; 125(3): e693–e98. doi: 10.1542/peds.2009-1984
4. Mariotti P, Iorio R, Frisullo G, Plantone D, Colantonio R, Tartaglione T, et al. Acute necrotizing encephalopathy during novel influenza A (H1N1) virus infection. Ann Neurol. 2010 Jul; 68(1):111-4. doi: 10.1002/ana.21996
5. Yamamoto H, Okumura A, Natsume J, Kojima S, Mizuguchi M. A severity score for acute necrotizing encephalopathy. Brain Dev. 2015 Mar; 37(3):322-7. doi: 10.1016/j.braindev.2014.05.007
6. Wang KY, Singer HS, Crain B, Gujar S, Lin DD. Hypoxic-ischemic encephalopathy mimicking acute necrotizing encephalopathy. Pediatr Neurol. 2015 Jan; 52(1):110-4. doi: 10.1016/j.pediatrneurol.2014.09.009
7. Hoshino A, Saitoh M, Oka A, Okumura A, Kubota M, Saito Y, et al. Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes. Brain Dev. 2012 May; 34(5):337-43. doi: 10.1016/j.braindev.2011.07.012
8. San Millan B, Teijeira S, Penin C, Garcia JL, Navarro C. Acute necrotizing encephalopathy of childhood: report of a Spanish case. Pediatr Neurol. 2007 Dec; 37(6):438-41.
9. Mastroyianni SD, Gionnis D, Voudris K, Skardoutsou A, Mizuguchi M. Acute necrotizing encephalopathy of childhood in non-Asian patients: report of three cases and literature review. J Child Neurol. 2006 Oct; 21(10):872-9.
10. Wang HS, Huang SC. Acute necrotizing encephalopathy of childhood. Chang Gung Med J. 2001 Jan; 24(1):1-10.
11. Lee JH, Lee M, Lee J. Recurrent acute necrotizing encephalopathy in a Korean child: the first non-Caucasian case. J Child Neurol. 2012 Oct; 27(10):1343-7.
12. Lyon JB, Remigio C, Milligan T, Deline C. Acute necrotizing encephalopathy in a child with H1N1 influenza infection. Pediatr Radiol. 2010 Feb; 40(2):200-5. doi: 10.1007/s00247-009-1487-z
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Bagheri Z, Hosseini S. Acute necrotizing encephalopathy childhood: a case report. J Gorgan Univ Med Sci 2016; 18 (3) :135-138
URL: http://goums.ac.ir/journal/article-1-2846-en.html


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Volume 18, Issue 3 (10-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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