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:: Volume 23, Issue 4 (12-2021) ::
J Gorgan Univ Med Sci 2021, 23(4): 18-25 Back to browse issues page
Effect of High-Intensity Interval Training on the Gene Expression of Eotaxin in Visceral Adipose Tissue and Insulin Resistance Following Metabolic Syndrome in Rats
Fatemeh Shojaei1 , Saeedeh Shadmehri * 2
1- M.Sc in Physical Education and Sport Science, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran.
2- Assistant Professor, Department of Physical Education and Sport Science, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran. , saeedehsh61@gmail.com
Abstract:   (4381 Views)
Background and Objective: Eotaxin is a pre-inflammatory adipokinin secreted from adipose tissue that plays an important role in function regulating of adipose tissue. This study was done to determine the effect of high-intensity interval training on the gene expression of eotaxin in visceral adipose tissue and insulin resistance following metabolic syndrome in rats.
Methods: In this experimental study, 40 male Wistar rats (weight 180±20 gr) were selected and after 12 weeks of high-fat diet and the creation of the metabolic syndrome model were randomly divided into four groups including  control, metabolic syndrome, High-Intensity Interval Training (HIIT) and metabolic syndrome with HIIT. Rats in the high-fat diet were subjected to a special diet (30 to 40% fat) for 12 weeks to develop a model of metabolic syndrome. HIIT consisted of 5 to 10 interval 1-minute intensive running on treadmill at 80 to 95% of maximum speed and in slow alternations at 55% of maximum speed for 8 weeks. Insulin resistance using HOMA-IR mode is considered as a basic factor for determining metabolic syndrome.
Results: The gene expression of eotaxin and insulin resistance in the metabolic syndrome group were significantly higher than the control group (P<0.05). Gene expression of eotaxin and insulin resistance was significantly lower in HIIT and metabolic syndrome with HIIT groups than the metabolic syndrome group (P<0.05). Also, the gene expression of eotaxin and insulin resistance was significantly lower in HIIT group than the metabolic syndrome with HIIT group.
Conclusion: It seems that HIIT may be an important factor in down-regulating eotaxin and insulin resistance in metabolic syndrome.
Keywords: Eotaxin , Metabolic Syndrome [MeSH], High-Intensity Interval Training [MeSH], Insulin Resistance [MeSH], Rat [MeSH]
Article ID: Vol23-49
Full-Text [PDF 672 kb]   (16855 Downloads)    
Type of Study: Original Articles | Subject: Exercise Physiology
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Shojaei F, Shadmehri S. Effect of High-Intensity Interval Training on the Gene Expression of Eotaxin in Visceral Adipose Tissue and Insulin Resistance Following Metabolic Syndrome in Rats. J Gorgan Univ Med Sci 2021; 23 (4) :18-25
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Volume 23, Issue 4 (12-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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