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:: Volume 23, Issue 4 (Winter 2022) ::
J Gorgan Univ Med Sci 2022, 23(4): 18-25 Back to browse issues page
Effect of High-Intensity Interval Training on the Gene Expression of Eotaxin in Visceral Adipose Tissue and Insulin Resistance Following Metabolic Syndrome in Rats
Fatemeh Shojaei1 , Saeedeh Shadmehri * 2
1- M.Sc in Physical Education and Sport Science, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran.
2- Assistant Professor, Department of Physical Education and Sport Science, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran. , saeedehsh61@gmail.com
Abstract:   (375 Views)
Background and Objective: Eotaxin is a pre-inflammatory adipokinin secreted from adipose tissue that plays an important role in function regulating of adipose tissue. This study was done to determine the effect of high-intensity interval training on the gene expression of eotaxin in visceral adipose tissue and insulin resistance following metabolic syndrome in rats.
Methods: In this experimental study, 40 male Wistar rats (weight 180±20 gr) were selected and after 12 weeks of high-fat diet and the creation of the metabolic syndrome model were randomly divided into four groups including  control, metabolic syndrome, High-Intensity Interval Training (HIIT) and metabolic syndrome with HIIT. Rats in the high-fat diet were subjected to a special diet (30 to 40% fat) for 12 weeks to develop a model of metabolic syndrome. HIIT consisted of 5 to 10 interval 1-minute intensive running on treadmill at 80 to 95% of maximum speed and in slow alternations at 55% of maximum speed for 8 weeks. Insulin resistance using HOMA-IR mode is considered as a basic factor for determining metabolic syndrome.
Results: The gene expression of eotaxin and insulin resistance in the metabolic syndrome group were significantly higher than the control group (P<0.05). Gene expression of eotaxin and insulin resistance was significantly lower in HIIT and metabolic syndrome with HIIT groups than the metabolic syndrome group (P<0.05). Also, the gene expression of eotaxin and insulin resistance was significantly lower in HIIT group than the metabolic syndrome with HIIT group.
Conclusion: It seems that HIIT may be an important factor in down-regulating eotaxin and insulin resistance in metabolic syndrome.
Keywords: Eotaxin , Metabolic Syndrome [MeSH], High-Intensity Interval Training [MeSH], Insulin Resistance [MeSH], Rat [MeSH],
Article ID: Vol23-49
Full-Text [PDF 703 kb]   (812 Downloads)    
Type of Study: Original Articles | Subject: Exercise Physiology
References
1. Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006. Natl Health Stat Report. 2009 May; (13): 1-7. Natl Health Stat Report. 2009 May; (13): 1-7. [PubMed]
2. Lim S, Kim JH, Yoon JW, Kang SM, Choi SH, Park YJ, et al. Sarcopenic obesity: prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA). Diabetes Care. 2010 Jul; 33(7): 1652-54. DOI: 10.2337/dc10-0107 [DOI] [PubMed]
3. van Vliet-Ostaptchouk JV, Nuotio ML, Slagter SN, Doiron D, Fischer K, Foco L, et al. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies. BMC Endocr Disord. 2014 Feb; 14: 9. [DOI] [PubMed]
4. Sigit FS, Tahapary DL, Trompet S, Sartono E, van Dijk KW, Rosendaal FR, et al. The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies. Diabetol Metab Syndr. 2020 Jan; 12: 2. DOI: 10.1186/s13098-019-0503-1 [DOI] [PubMed]
5. Neacsu M, Fyfe C, Horgan G, Johnstone AM. Appetite control and biomarkers of satiety with vegetarian (soy) and meat-based high-protein diets for weight loss in obese men: a randomized crossover trial. Am J Clin Nutr. 2014 Aug; 100(2): 548-58. DOI: 10.3945/ajcn.113.077503 [DOI] [PubMed]
6. Iwaki T, Urano T, Umemura K. PAI-1, progress in understanding the clinical problem and its aetiology. Br J Haematol. 2012 May; 157(3): 291-8. DOI: 10.1111/j.1365-2141.2012.09074.x [DOI] [PubMed]
7. Asgary S, SamsamShariat SZ, Ghorbani A, Keshvari M, Sahebkar A, Sarrafzadegan N. Relationship between serum resistin concentrations with metabolic syndrome and its components in an Iranian population. Diabetes Metab Syndr. 2015 Oct-Dec; 9(4): 266-70. DOI: 10.1016/j.dsx.2014.09.007 [DOI] [PubMed]
8. Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Nov; 13(11): 633-43. DOI: 10.1038/nrendo.2017.90 [DOI] [PubMed]
9. Coimbra S, Catarino C, Santos-Silva A. The triad psoriasis-obesity-adipokine profile. J Eur Acad Dermatol Venereol. 2016 Nov; 30(11): 1876-85. DOI: 10.1111/jdv.13701 [DOI] [PubMed]
10. Ghorbanian B, Saberi Y. [The Effects of Eight Weeks of Progressive Resistance Training on Eotaxin Serum Levels in Overweight and Obese Men]. Armaghane Danesh. 2016; 21(4): 321-34. [Article in Persian] [View at Publisher]
11. Loughrey BV, McGinty A, Young IS, McCance DR, Powell LA. Increased circulating CC chemokine levels in the metabolic syndrome are reduced by low-dose atorvastatin treatment: evidence from a randomized controlled trial. Clin Endocrinol (Oxf). 2013 Dec; 79(6): 800-6. DOI: 10.1111/cen.12113 [DOI] [PubMed]
12. Vasudevan AR, Wu H, Xydakis AM, Jones PH, O'Brian Smith E, Sweeney JF, et al. Eotaxin and obesity. J Clin Endocrinol Metab. 2006 Jan; 91(1): 256-61. DOI: 10.1210/jc.2005-1280 [DOI] [PubMed]
13. Ghasemnian A, Ghaeini A, Kordi M, Hedayati M, Rami M, Ghorbanian B. [The effect of eight weeks of interval endurance training on plasma eotaxin, adiponectin levels, insulin resistance, serum lipid profile, and body composition in overweight and obese adolescents]. Stud Med Sci. 2013; 24(6): 430-40. [Article in Persian] [View at Publisher]
14. Roden M, Petersen K, Shulman G. Insulin Resistance in Type 2 Diabetes. In: Holt RI, Cockram C, Flyvbjerg A, Goldstein BJ. Textbook of Diabetes. 5th ed. New York: John Wiley & Sons. 2017; pp: 174-86.
15. Mauvais-Jarvis F. Sex differences in metabolic homeostasis, diabetes, and obesity. Biol Sex Differ. 2015 Sep; 6: 14. DOI: 10.1186/s13293-015-0033-y [DOI] [PubMed]
16. Cho SY, Roh HT. Effects of aerobic exercise training on peripheral brain-derived neurotrophic factor and eotaxin-1 levels in obese young men. J Phys Ther Sci. 2016 Apr; 28(4): 1355-58. DOI: 10.1589/jpts.28.1355 [DOI] [PubMed]
17. Fekri Kourabbaslou V, Motamedi P, Amani Shalamzari S. [The effect of six weeks of interval resistance training on eotaxin and brain-derived neurotrophic factor serum levels in overweight young men]. Research in Sport Medicine and Technology. 2018; 16(15): 23-34. [Article in Persian] [PubMed]
18. Kim HJ, Kim CH, Lee DH, Han MW, Kim MY, Ju JH, et al. Expression of eotaxin in 3T3-L1 adipocytes and the effects of weight loss in high-fat diet induced obese mice. Nutr Res Pract. 2011 Feb; 5(1): 11-19. DOI: 10.4162/nrp.2011.5.1.11 [DOI] [PubMed]
19. Jefferis BJ, Parsons TJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, et al. Does duration of physical activity bouts matter for adiposity and metabolic syndrome? A cross-sectional study of older British men. Int J Behav Nutr Phys Act. 2016; 13: 36. DOI: 10.1186/s12966-016-0361-2 [Article] [DOI]
20. Gibala MJ, Little JP, van Essen M, Wilkin GP, Burgomaster KA, Safdar A, et al. Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol. 2006 Sep; 575(Pt 3): 901-11. DOI: 10.1113/jphysiol.2006.112094 [DOI] [PubMed]
21. Homayounfar R, Ehrampoush E, Koohpaye SA, Meshkibaf MH, Taghizade S, Almasi A, et al . [Diet-induced metabolic syndrome model in rats]. J Advanced Biomed Sci. 2013; 2(4): 288-96. [Article in Persian] [View at Publisher]
22. Antunes LC, Elkfury JL, Jornada MN, Foletto KC, Bertoluci MC. Validation of HOMA-IR in a model of insulin-resistance induced by a high-fat diet in Wistar rats. Arch Endocrinol Metab. 2016 Apr;60(2):138-42. DOI: 10.1590/2359-3997000000169 [DOI] [PubMed]
23. Robinson E, Durrer C, Simtchouk S, Jung ME, Bourne JE, Voth E, et al. Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes. J Appl Physiol (1985). 2015 Sep; 119(5): 508-16. dOI: 10.1152/japplphysiol.00334.2015 [DOI] [PubMed]
24. Machado MV, Vieira AB, da Conceição FG, Nascimento AR, da Nóbrega ACL, Tibirica E. Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. Exp Physiol. 2017 Dec; 102(12): 1716-28. DOI: 10.1113/EP086416 [DOI] [PubMed]
25. Zeve D. The Response of White Adipose Progenitor Cells to Physiological and Genetic Changes. Thesis. Ph.D Doctoral in Genetics and Development. University of Texas Southwestern Medical Center. 2013 [View at Publisher]
26. Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, Kim SM. Effect of exercise training on plasma visfatin and eotaxin levels. Eur J Endocrinol. 2007 Oct; 157(4): 437-42. DOI: 10.1530/EJE-07-0127 [DOI] [PubMed]
27. Askari R, Ravasi AA, Gaeini AA, Hedayati M , Hamedinia MR. [The effect of combined exercise training on some adipokines and insulin sensitivity index in overweight females]. Journal of Sport in Biomotor Sciences. 2011; 5(1): 25-37. [Article in Persian] [View at Publisher]
28. Rhee EJ. Chemerin: A Novel Link between Inflammation and Atherosclerosis? Diabetes Metab J. 2011 Jun; 35(3): 216-18. DOI: 10.4093/dmj.2011.35.3.216 [DOI] [PubMed]
29. Toloueiazar J, Tofighi A, Alizadeh R. [The Effect of High Intensity Interval Training on Serum Levels of FGF21, Insulin Resistance and Lipid Profile in Sedentary Obese Women]. Journal of Sport Biosciences. 2019; 10(4): 449-64. DOI: 10.22059/jsb.2018.245057.1216 [Article in Persian] [View at Publisher] [DOI]
30. Jelleyman C, Yates T, O'Donovan G, Gray LJ, King JA, Khunti K, et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev. 2015 Nov; 16(11): 942-61. DOI: 10.1111/obr.12317 [DOI] [PubMed]
31. Obert J, Pearlman M, Obert L, Chapin S. Popular Weight Loss Strategies: a Review of Four Weight Loss Techniques. Curr Gastroenterol Rep. 2017 Nov; 19(12): 61. DOI: 10.1007/s11894-017-0603-8 [DOI] [PubMed]
32. Sampath Kumar A, Maiya AG, Shastry BA, Vaishali K, Ravishankar N, Hazari A, et al. Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis. Ann Phys Rehabil Med. 2019 Mar; 62(2): 98-103. DOI: 10.1016/j.rehab.2018.11.001 [DOI] [PubMed]
33. Keshel TE, Coker RH. Exercise Training and Insulin Resistance: A Current Review. J Obes Weight Loss Ther. 2015 Jul; 5(Suppl 5): S5-003. DOI: 10.4172/2165-7904.S5-003 [DOI] [PubMed]
34. Petersen MC, Shulman GI. Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev. 2018 Oct; 98(4): 2133-23. DOI: 10.1152/physrev.00063.2017 [DOI] [PubMed]
35. Baharloo S, Taghiyan F, Hedayati M. [Effect of aerobic exercise on glucose, insulin and insulin resistance in subclinical hypothyroidism overweight-obese women]. Razi J Med Sci. 2014; 21 (125) :75-84. [Article in Persian] [View at Publisher]
36. Moghaddami K, Mohebbi H, Tabari E, Faridnia M. [A Comparison of the Effect of 12 Weeks of Interval Training with High and Moderate Intensity on Perilipin 3 of Visceral Adipose Tissue and Insulin Resistance in Type 2 Diabetic Male Rats]. Journal of Sport BioScineces. 2019; 11(1): 35-48. DOI: 10.22059/jsb.2018.261519.1289 [Article in Persian] [View at Publisher] [DOI]
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Shojaei F, Shadmehri S. Effect of High-Intensity Interval Training on the Gene Expression of Eotaxin in Visceral Adipose Tissue and Insulin Resistance Following Metabolic Syndrome in Rats. J Gorgan Univ Med Sci. 2022; 23 (4) :18-25
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Volume 23, Issue 4 (Winter 2022) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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