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Simultaneous Evaluation of the Clinical Epidemiology of Tuberculosis and Coronavirus Disease 2019 in Patients Admitted to the Fifth Azar Educational-Therapeutic Center in Gorgan, Iran (2020-2022)
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Matin Zafar Shokourzadeh1    , Ebrahim Kouhsari*2 , Taghi Amiriani3 , Ali Asghar Ayatollah *4 |
1- M.Sc in Medical Laboratory Sciences, Research Center of Medical Laboratories, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran.
2- Assistant Professor of Medical Laboratory Sciences, Center for Medical Laboratory Research, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran. ekouhsari1987@gmail.com
3- Professor of Adult Gastroenterology and Hepatology, Research Center of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
4- Academic Instrctor, Center for Research in Laboratory Sciences, Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Golestan University of Medical Sciences, Gorgan, Iran. , ayatollahilab@gmail.com |
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Abstract: (399 Views) |
Background and Objective: The co-infection of tuberculosis (TB) and coronavirus disease 2019 (COVID-19) presents a significant global health challenge. Golestan Province is considered one of the most important hubs for TB. This study was conducted to simultaneously evaluate the clinical epidemiology of TB and COVID-19 in patients admitted to the Fifth Azar Educational-Therapeutic Center in Gorgan, Iran.
Methods: This retrospective, descriptive-analytical study was performed on 22 patients (12 men and 10 women) with active or old TB and COVID-19 admitted to the Fifth Azar Educational-Therapeutic Center in Gorgan, Iran, during 2020-2022. Clinical data and real-time polymerase chain reaction (RT-PCR) results were extracted from patients’ records in the hospital. These data, encompassing nasopharyngeal swab specimens from the upper respiratory tract, as well as tracheal aspirate specimens, were compiled into a checklist format.
Results: Of the 22 patients, 13 were deceased and 9 recovered. Patient hospitalization wards included the intensive care unit (ICU) (36%), respiratory isolation (36%), surgery (4.5%), and infectious diseases (23%). All patients ICU-admitted (100%) were in the deceased group (P<0.05). The clinical symptom of dyspnea was present in all 13 deceased patients (P<0.05). Laboratory results showed that alanine transaminase (ALT) and blood urea nitrogen (BUN) values were significantly higher in the deceased group than in the recovered group (P<0.05). Hematological indices, including white blood cell (WBC) count, hemoglobin (Hb), hematocrit (Hct), and mean corpuscular hemoglobin concentration (MCHC), were significantly higher in the recovered group compared to the deceased group (P<0.05).
Conclusion: The probability of death is higher in patients with TB and COVID-19 co-infection who experience dyspnea, require ICU admission, and have increased ALT and BUN laboratory values.
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Keywords: Tuberculosis [MeSH], COVID-19 [MeSH], Coinfection [MeSH]
Article ID: Vol27-25 |
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Full-Text [PDF 684 kb]
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Type of Study: Original Articles |
Subject:
Infectious Medicine
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Zafar Shokourzadeh M, Kouhsari* E, Amiriani T, Ayatollah A A. Simultaneous Evaluation of the Clinical Epidemiology of Tuberculosis and Coronavirus Disease 2019 in Patients Admitted to the Fifth Azar Educational-Therapeutic Center in Gorgan, Iran (2020-2022). J Gorgan Univ Med Sci 2025; 27 (3) :39-47 URL: http://goums.ac.ir/journal/article-1-4545-en.html
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