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Comparing the Frequency of Helicobacter pylori Infection in Patients with and without Epilepsy in the Northwest of Iran (2019)
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Farhad Pourfarzi1    , Ghasem Fattahzadeh-Ardalani * 2, Mehdi Aalipour-Erdi3 |
1- Professor, Department of Community Medicine, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
2- Associate Professor, Department of Neurology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. , g.fattahzadeh2015@gmail.com
3- General Physician, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. |
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Abstract: (657 Views) |
Background and Objective: Helicobacter pylori infection is a chronic bacterial infection in humans, and its link to epilepsy has been reported in some studies. This study was conducted to compare the frequency of Helicobacter pylori infection in patients with and without epilepsy.
Methods: This case-control study was conducted on 234 patients with focal and generalized epilepsy (the case group consisted of 88 males and 146 females) referring to Alavi Hospital in Ardabil, Iran and 234 individuals without epilepsy (the control group consisted of 88 males and 146 females) during 2019. Stool samples were taken from the subjects to assess the Helicobacter pylori stool antigen. Demographic information, including age, gender, place of residence, a history of alcohol, cigarette, hookah, and opium use, and the test result of the Helicobacter pylori stool antigen, were collected in a checklist.
Results: The frequency of Helicobacter pylori infection was determined to be 67.2% in the case group and 71.1% in the control group, and no statistically significant difference was found between the case and control groups. Cigarette and opium use had statistically significant relationships with epilepsy (P<0.05). Moreover, opium users had a 6.92 times higher odds rate (OR) of contracting Helicobacter pylori infection than other individuals (CI 95%=1.05-45, OR=6.92, P<0.04).
Conclusion: No difference was observed in Helicobacter pylori infection between individuals with and without epilepsy. |
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Keywords: Epilepsy [MeSH], Helicobacter pylori [MeSH], Feces Sample [MeSH]
Article ID: Vol25-45 |
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Full-Text [PDF 532 kb]
(1360 Downloads)
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Type of Study: Original Articles |
Subject:
Microbiology
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1. Dunn BE, Cohen H, Blaser MJ. Helicobacter pylori. Clin Microbiol Rev. 1997 Oct; 10(4): 720-41. doi: 10.1128/CMR.10.4.720. [ DOI] [ PubMed] 2. Pourfarzi F, Whelan A, Kaldor J, Malekzadeh R. The role of diet and other environmental factors in the causation of gastric cancer in Iran--a population based study. Int J Cancer. 2009 Oct; 125(8): 1953-60. doi: 10.1002/ijc.24499. [ DOI] [ PubMed] 3. Aceti A, Are R, Sabino G, Fenu L, Pasquazzi C, Quaranta G, et al. Helicobacter pylori active infection in patients with acute coronary heart disease. J Infect. 2004 Jul; 49(1): 8-12. doi: 10.1016/j.jinf.2004.01.011. [ DOI] [ PubMed] 4. Emilia G, Longo G, Luppi M, Gandini G, Morselli M, Ferrara L, et al. Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura. Blood. 2001 Feb; 97(3): 812-14. doi: 10.1182/blood.v97.3.812. [ DOI] [ PubMed] 5. Ozturk A, Ozturk CE, Ozdemirli B, Yucel M, Bahçebaşi T. Helicobacter pylori infection in epileptic patients. Seizure. 2007 Mar; 16(2): 147-52. doi: 10.1016/j.seizure.2006.10.015. [ DOI] [ PubMed] 6. Okuda M, Miyashiro E, Nakazawa T, Minami K, Koike M. Helicobacter pylori infection and idiopathic epilepsy. Am J Med. 2004 Feb; 116(3): 209-10. doi: 10.1016/j.amjmed.2003.05.005. [ DOI] [ PubMed] 7. Kountouras J, Tsolaki M, Gavalas E, Boziki M, Zavos C, Karatzoglou P, et al. Relationship between Helicobacter pylori infection and Alzheimer disease. Neurology. 2006 Mar; 66(6): 938-40. doi: 10.1212/01.wnl.0000203644.68059.5f. [ DOI] [ PubMed] 8. 8. Yao, G, Wang P, Luo XD, Yu TM. Meta-analysis of Association between Helicobacter pylori Infection and Epilepsy. Int J Brain Disord Treat. 2015; 2(2): 1-4. doi: 10.23937/2469-5866/1510016. [ Link] [ DOI] 9. Asadi-Pooya AA, Dehghani SM, Petramfar P, Emami M, Mahmoodi M. Helicobacter pylori infection in patients with epilepsy. Seizure. 2012 Jan; 21(1): 21-23. doi: 10.1016/j.seizure.2011.08.011. [ DOI] [ PubMed] 10. Asadi-Pooya AA, Dehghani SM, Emami M. Effect of treating helicobacter pylori infection on seizure frequency in patients with refractory epilepsy. Iran J Neurol. 2011; 10(3-4): 51-53. [ PubMed] 11. Abdul Razak MR, Tan HJ, Razlan H, Ibrahim NM, Sutan R. Prevalence of Helicobacter pylori infection in epilepsy patients in a teaching hospital in Malaysia. Neurology Asia. 2012; 17(4): 293-96. [ Link] 12. Cojocaru IM, Cojocaru M. Reactions of the immune system in epilepsy. Maedica (Bucur). 2010 Jul; 5(3): 201-206. [ PubMed] 13. Bartolomei F, Boucraut J, Barrié M, Kok J, Dravet C, Viallat D, et al. Cryptogenic partial epilepsies with anti-GM1 antibodies: a new form of immune-mediated epilepsy? Epilepsia. 1996 Oct; 37(10): 922-26. doi: 10.1111/j.1528-1157.1996.tb00527.x. [ DOI] [ PubMed] 14. Friedman A, Kaufer D, Heinemann U. Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy. Epilepsy Res. 2009 Aug; 85(2-3): 142-49. doi: 10.1016/j.eplepsyres.2009.03.005. [ DOI] [ PubMed] 15. Kountouras J, Zavos C, Deretzi G, Polyzos SA, Katsinelos P, Anastasiadou K, et al. Helicobacter pylori might be a potential therapeutic target in epilepsy. Med Hypotheses. 2011 May; 76(5): 763. doi: 10.1016/j.mehy.2011.02.004. [ DOI] [ PubMed] 16. Sadjadi A, Derakhshan MH, Yazdanbod A, Boreiri M, Parsaeian M, Babaei M, et al. Neglected role of hookah and opium in gastric carcinogenesis: a cohort study on risk factors and attributable fractions. Int J Cancer. 2014 Jan; 134(1): 181-88. doi: 10.1002/ijc.28344. [ DOI] [ PubMed] |
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Pourfarzi F, Fattahzadeh-Ardalani G, Aalipour-Erdi M. Comparing the Frequency of Helicobacter pylori Infection in Patients with and without Epilepsy in the Northwest of Iran (2019). J Gorgan Univ Med Sci 2023; 25 (4) :51-56 URL: http://goums.ac.ir/journal/article-1-4318-en.html
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