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:: Volume 24, Issue 4 (12-2022) ::
J Gorgan Univ Med Sci 2022, 24(4): 85-90 Back to browse issues page
Prevalence of Ventilator-Associated Pneumonia and Evaluation of Serum C-Reactive Protein, Hemoglobin, and Procalcitonin Levels as their Biomarkers Among Brain Trauma Patients in 5th Azar Hospital, Gorgan, Iran
Seiede Roya Mousavi1 , Mansour Deylami * 2, Ramin Azarhoush3 , Arazberdi Ghourchaei4 , Kazem Kazemnejad4 , Seyedbabak Mojaveraghili1 , Seyedeh Mahrokh Alinaghimaddah1 , Seied Amirhassan Mousavi5
1- Assistant Professor , Department of Anesthesiology, Medical School, Golestan University of Medical Sciences, Gorgan, Iran.
2- Assistant Professor , Department of Anesthesiology, Medical School, Golestan University of Medical Sciences, Gorgan, Iran. , mansour.deylami@gmail.com
3- Associate Professor, Department of Pathology, Medical School, Golestan University of Medical Sciences, Gorgan, Iran.
4- Associate Professor , Department of Anesthesiology, Medical School, Golestan University of Medical Sciences, Gorgan, Iran.
5- Pharmacist, Faculty of Pharmaceutical Science, Tehran Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (1277 Views)
Background and Objective: Ventilator-associated pneumonia (VAP) is an important complication in intensive care unit (ICU) patients with endotracheal intubation. Finding potential early indicators of this condition can aid in reducing the disease burden. We aimed to investigate the relationship between VAP occurrence and serum levels of C-reactive protein (CRP), procalcitonin (PCT), and hemoglobin (Hgb) during ICU hospitalization of brain trauma patients.
Method: This descriptive-analytical study was carried out on brain trauma patients (99 male, 39 female), referring to the 5th Azar hospital in Gorgan, Iran, in the course of 2017. The patients were hospitalized in ICU with endotracheal intubation and mechanical ventilation. The diagnosis of VAP was confirmed by a 12-score rating based on chest radiographs, body temperature, white blood cell count, and sputum culture. After admission, serum CRP, PCT, and Hgb were documented daily for 6 days.
Results: According to the diagnostic criteria, VAP was confirmed in 41 patients (30%). Serum CRP and PCT levels on the 6th-day post-admission were significantly associated with VAP diagnosis, while Hgb levels did not differ significantly between VAP and non-VAP patients. Serum levels of CRP, PCT, and Hgb on the 6th day were not associated with age or sex.
Conclusion: Our results indicate that serum CRP and PCT levels are associated with the occurrence of VAP in ICU patients receiving mechanical ventilation. Therefore, these biomarkers could be utilized to warn physicians about the possibility of VAP, thereby reducing mortality rate and hospitalization length.

Keywords: Pneumonia Ventilator-Associated [MeSH], Procalcitonin [MeSH], C-Reactive Protein [MeSH], Hemoglobin [MeSH]
Article ID: Vol24-55
Full-Text [PDF 683 kb]   (4732 Downloads)    
Type of Study: Original Articles | Subject: Anesthesiology and Pain
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Mousavi S R, Deylami M, Azarhoush R, Ghourchaei A, Kazemnejad K, Mojaveraghili S, et al . Prevalence of Ventilator-Associated Pneumonia and Evaluation of Serum C-Reactive Protein, Hemoglobin, and Procalcitonin Levels as their Biomarkers Among Brain Trauma Patients in 5th Azar Hospital, Gorgan, Iran. J Gorgan Univ Med Sci 2022; 24 (4) :85-90
URL: http://goums.ac.ir/journal/article-1-4065-en.html

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Volume 24, Issue 4 (12-2022) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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