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:: Volume 24, Issue 2 (7-2022) ::
J Gorgan Univ Med Sci 2022, 24(2): 31-40 Back to browse issues page
A Comprehensive Evaluation of Executive Functions Using the Cambridge Neuropsychological Test Automated Battery in People with Major Depressive Disorder
Leyly Ramezan Saatchi1 , Roshanak Khodabakhsh Pirkalani * 2, Seyed Abolghasem Mehrinejad3
1- Ph.D Candidate in Psychology, Faculty of Education and Psychology Alzahra University, Tehran ,Iran.
2- Associate Professor, Department of Psychology, Faculty of Education and Psycology, Alzahra University, Tehran, Iran. , rkhodabakhsh@alzahra.ac.ir
3- Associate Professor, Department of Psychology, Faculty of Education and Psycology, Alzahra University, Tehran, Iran.
Abstract:   (2862 Views)
Background and Objective: Major depression is a common disease in the world, which is associated with cognitive impairment. Executive functions are among the cognitive functions that are influenced by major depression. This study was conducted to comprehensively evaluate the executive functions of people with major depressive disorder and normal people using the Cambridge Neuropsychological Test Automated Battery (CANTAB).
Methods: This case-control study was conducted on 13 patients with major depressive disorder and 13 normal individuals aged 21 to 35 years who were referred to psychology and psychiatry centers in Tehran (Iran) in 2019. The subjects were randomly selected from six centers in four districts of Tehran and then divided into an experimental group and a healthy control group. Both groups were subjected to cognitive assessment using the CANTAB, n-back test as well as Daneman and Carpenter's working memory sentences.
Results: The mean of executive functions was significantly lower in people with major depressive disorder compared to their healthy counterparts (P<0.05). When examining the components of executive functions in both the experimental and control groups, there was a significant increase in the shifting in the total number of errors and the inhibition component in direction errors. In addition, there was a statistically significant decrease in the updating component in errors 1 and error 2 and an increase in time 2. Furthermore, there was a significant increase in the component of working memory maintenance in error as well as the planning component in the average delay (response speed) to the first choice, to correct the error and a decrease in working memory manipulation (P<0.05).
Conclusion: Our findings indicate that the executive functions of people with major depressive disorder are lower than healthy counterparts according to the CANTAB.
 
Keywords: Major Depressive Disorder [MeSH], Executive Function [MeSH], Neuropsychological Tests [MeSH]
Article ID: Vol24-19
Full-Text [PDF 685 kb]   (12669 Downloads)    
Type of Study: Original Articles | Subject: Psychiatry
References
1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov; 392(10159): 1789-858. DOI: 10.1016/S0140-6736(18)32279-7 [DOI] [PubMed]
2. Greenberg PE, Fournier AA, Sisitsky T, Pike CT, Kessler RC. The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry. 2015 Feb; 76(2): 155-62. DOI: 10.4088/JCP.14m09298 [DOI] [PubMed]
3. Wang PS, Aguilar-Gaxiola S, Alonso J, Angermeyer MC, Borges G, Bromet EJ, et al. Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys. Lancet. 2007 Sep; 370(9590): 841-50. DOI: 10.1016/S0140-6736(07)61414-7 [DOI] [PubMed]
4. Bostwick JM, Pankratz VS. Affective disorders and suicide risk: a reexamination. Am J Psychiatry. 2000 Dec; 157(12): 1925-32. DOI: 10.1176/appi.ajp.157.12.1925 [DOI] [PubMed]
5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 5th ed. Washington, DC: American Psychiatric Publishing. 2013; p: 6.
6. Halahakoon DC, Lewis G, Roiser JP. Cognitive Impairment and Depression-Cause, Consequence, or Coincidence? JAMA Psychiatry. 2019 Mar; 76(3): 239-40. DOI: 10.1001/jamapsychiatry.2018.3631 [DOI] [PubMed]
7. Afridi MI, Hina M, Qureshi IS, Hussain M. Cognitive disturbance comparison among drug-naïve depressed cases and healthy controls. J Coll Physicians Surg Pak. 2011 Jun; 21(6): 351-55. [PubMed]
8. Ahern E, Semkovska M. Cognitive functioning in the first-episode of major depressive disorder: A systematic review and meta-analysis. Neuropsychology. 2017 Jan; 31(1): 52-72. DOI: 10.1037/neu0000319 [DOI] [PubMed]
9. Rock PL, Roiser JP, Riedel WJ, Blackwell AD. Cognitive impairment in depression: a systematic review and meta-analysis. Psychol Med. 2014 Jul; 44(10): 2029-40. DOI: 10.1017/S0033291713002535 [DOI] [PubMed]
10. Motter JN, Pimontel MA, Rindskopf D, Devanand DP, Doraiswamy PM, Sneed JR. Computerized cognitive training and functional recovery in major depressive disorder: A meta-analysis. J Affect Disord. 2016 Jan; 189: 184-91. DOI: 10.1016/j.jad.2015.09.022 [DOI] [PubMed]
11. Diamond A. Executive functions. Annu Rev Psychol. 2013; 64: 135-68. DOI: 10.1146/annurev-psych-113011-143750 [DOI] [PubMed]
12. Friedman NP, Miyake A. Unity and diversity of executive functions: Individual differences as a window on cognitive structure. Cortex. 2017 Jan; 86: 186-204. DOI: 10.1016/j.cortex.2016.04.023 [Article] [DOI]
13. Zetsche U, D'Avanzato C, Joormann J. Depression and rumination: relation to components of inhibition. Cogn Emot. 2012; 26(4): 758-67. DOI: 10.1080/02699931.2011.613919 [DOI] [PubMed]
14. De Lissnyder E, Koster EH, Goubert L, Onraedt T, Vanderhasselt MA, De Raedt R. Cognitive control moderates the association between stress and rumination. J Behav Ther Exp Psychiatry. 2012 Mar; 43(1): 519-25. DOI: 10.1016/j.jbtep.2011.07.004 [DOI] [PubMed]
15. Snyder HR, Kaiser RH, Whisman MA, Turner AE, Guild RM, Munakata Y. Opposite effects of anxiety and depressive symptoms on executive function: the case of selecting among competing options. Cogn Emot. 2014; 28(5): 893-902. DOI: 10.1080/02699931.2013.859568 [DOI] [PubMed]
16. Snyder HR, Miyake A, Hankin BL. Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches. Front Psychol. 2015 Mar; 6: 328. DOI: 10.3389/fpsyg.2015.00328 [DOI] [PubMed]
17. Repovs G, Baddeley A. The multi-component model of working memory: explorations in experimental cognitive psychology. Neuroscience. 2006 Apr; 139(1): 5-21. DOI: 10.1016/j.neuroscience.2005.12.061 [DOI] [PubMed]
18. Mowlaie M, Hatami J, Rostami R. [The Comparison of Executive Functions in Obsessive-Compulsive Disorder and Major Depressive Disorder Patients with Healthy Individuals]. Advances in Cognitive Sciences. 2014; 16(3): 61-71. [Article in Persian] [View at Publisher]
19. Ajilchi B, Ahadi H, Nejati V, Delavar A. [Executive Functions in Depressed and Non-depressed Individuals]. Journal of Clinical Psychology. 2013 Jul; 5(2): 77-88. DOI: 10.22075/jcp.2017.2129 [Article in Persian] [View at Publisher] [DOI]
20. Bodaghi E. [Comparison of Executive functions in Women with MS Comorbid with and without Depression, and Normal women]. Neuropsychology. 2016; 2(5): 39-56. [Article in Persian] [View at Publisher]
21. Beloe P, Derakshan N. Adaptive working memory training can reduce anxiety and depression vulnerability in adolescents. Dev Sci. 2020 Jul; 23(4): e12831. DOI: 10.1111/desc.12831 [DOI] [PubMed]
22. Haidarpor S, Ghaderi D, Mahmodfakhe H. Comparison of executive functions and neurological characteristics of depressed patients with and without suicidal ideation and normal group. Studies in Medical Sciences. 2019; 29(11): 837-47. [View at Publisher]
23. Cochran WG. Sampling techniques. 3rd Ed. New York: John Wiley & Sons. 1991.
24. Michopoulos I, Zervas IM, Papakosta VM, Tsaltas E, Papageorgiou C, Manessi T, et al. Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings. Eur Psychiatry. 2006 Sep; 21(6): 361-63. DOI: 10.1016/j.eurpsy.2006.03.008 [DOI] [PubMed]
25. Matthews K, Coghill D, Rhodes S. Neuropsychological functioning in depressed adolescent girls. J Affect Disord. 2008 Nov; 111(1): 113-18. DOI: 10.1016/j.jad.2008.02.003 [DOI] [PubMed]
26. Rajabi G, Karju Kasmai S. [Psychometric properties of a Persian language version of the beck depression inventory second edition]. Quarterly of Educational Measurement. 2012; 3(10): 139-58. [Article in Persian] [View at Publisher]
27. Beck AT, Steer RA, Carbin MG. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review. 1988; 8(1): 77-100. DOI: 10.1016/0272-7358(88)90050-5 [Article] [DOI]
28. Rahimi C. [Application of the Beck Depression Inventory-II in Iranian University Students]. Clinical Psychology and Personality. 2014; 12(1): 173-88. [Article in Persian] [View at Publisher]
29. Omidi Hosein Abadi H, Abbasi Esfajir AA. [To Assess The Effects of The Night Shift Work in Nurses' Depression And Anxiety in Hospitals of Chalous]. Nursing Management. 2015; 4(2): 29-38. [Article in Persian] [View at Publisher]
30. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988 Dec; 56(6): 893-97. DOI: 10.1037//0022-006x.56.6.893 [DOI] [PubMed]
31. Beck AT, Clark DA. Anxiety and depression: An information processing perspective. Anxiety Research. 1988; 1(1): 23-36. DOI: 10.1080/10615808808248218 [Article] [DOI]
32. Hossein Kaviani H, Mousavi AS. [Psychometric properties of the Persian version of Beck Anxiety Inventory (BAI)]. Tehran Univ Med J. 2008; 66(2): 136-40. [Article in Persian] [View at Publisher]
33. Wild K, Howieson D, Webbe F, Seelye A, Kaye J. Status of computerized cognitive testing in aging: a systematic review. Alzheimers Dement. 2008 Nov; 4(6): 428-37. DOI: 10.1016/j.jalz.2008.07.003 [DOI] [PubMed]
34. Smith PJ, Need AC, Cirulli ET, Chiba-Falek O, Attix DK. A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instruments. J Clin Exp Neuropsychol. 2013; 35(3): 319-28. DOI: 10.1080/13803395.2013.771618 [DOI] [PubMed]
35. Saunders NL, Summers MJ. Attention and working memory deficits in mild cognitive impairment. J Clin Exp Neuropsychol. 2010 Apr; 32(4): 350-57. DOI: 10.1080/13803390903042379 [DOI] [PubMed]
36. Green R, Till C, Al-Hakeem H, Cribbie R, Téllez-Rojo MM, Osorio E, et al. Assessment of neuropsychological performance in Mexico City youth using the Cambridge Neuropsychological Test Automated Battery (CANTAB). J Clin Exp Neuropsychol. 2019 Apr; 41(3): 246-56. DOI: 10.1080/13803395.2018.1529229 [DOI] [PubMed]
37. Potter GG, McQuoid DR, Payne ME, Taylor WD, Steffens DC. Association of attentional shift and reversal learning to functional deficits in geriatric depression. Int J Geriatr Psychiatry. 2012 Nov; 27(11): 1172-79. DOI: 10.1002/gps.3764 [DOI] [PubMed]
38. Farahmand Z, Tehrani-Doost M, Amini H, Mohammadi A, Mirzaei M, Mohamadzadeh A. Working Memory and Response Inhibition in Patients With Bipolar I Disorder During Euthymic Period. Iran J Psychiatry Behav Sci. 2015 Mar; 9(1): e209. DOI: 10.17795/ijpbs209 [DOI] [PubMed]
39. Cacciamani F, Salvadori N, Eusebi P, Lisetti V, Luchetti E, Calabresi P, et al. Evidence of practice effect in CANTAB spatial working memory test in a cohort of patients with mild cognitive impairment. Appl Neuropsychol Adult. 2018 May-Jun; 25(3): 237-48. DOI: 10.1080/23279095.2017.1286346 [DOI] [PubMed]
40. CANTABeclipseTM. Test Administration Guide. version 3.0.0. Cambridge. 2006.
41. Kirchner WK. Age differences in short-term retention of rapidly changing information. J Exp Psychol. 1958 Apr; 55(4): 352-58. DOI: 10.1037/h0043688 [DOI] [PubMed]
42. Bozorgmehr A, Bozorgmehr M. [The Effect of Education Level on Working Memory Performance]. Neuropsychology, 2016; 1(3): 68-79. [Article in Persian] [View at Publisher]
43. Kane MJ, Conway ARA, Miura TK, Colflesh GJH. Working memory, attention control, and the N-back task: a question of construct validity. J Exp Psychol Learn Mem Cogn. 2007 May; 33(3): 615-22. DOI: 10.1037/0278-7393.33.3.615 [DOI] [PubMed]
44. Mousa Beigi T, Zare H, Sharifi A A. [The Effect of Cognitive Rehabilitation on the Working Memory of Women with Breast Cancer under Chemotherapy]. JHPM. 2018; 7(5): 23-29. [Article in Persian] [View at Publisher]
45. Zamani A, Pouratashi M. [The relationship between academic performance and working memory, self-efficacy belief, and test anxiety]. Journal of School Psychology. 2018; 6(4): 25-44. DOI: 10.22098/jsp.2018.603 [Article in Persian] [View at Publisher]
46. Snyder HR, Kaiser RH, Warren SL, Heller W. Obsessive-compulsive disorder is associated with broad impairments in executive function: A meta-analysis. Clin Psychol Sci. 2015 Mar; 3(2): 301-30. DOI: 10.1177/2167702614534210 [DOI] [PubMed]
47. Shallice T. Fractionation of the Supervisory System. Principles of Frontal Lobe Function. In: Stuss DT, Knight RT. Oxford Academic. 2002; pp: 261-77. DOI: 10.1093/acprof:oso/9780195134971.003.0017 [DOI]
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Ramezan Saatchi L, Khodabakhsh Pirkalani R, Mehrinejad S A. A Comprehensive Evaluation of Executive Functions Using the Cambridge Neuropsychological Test Automated Battery in People with Major Depressive Disorder. J Gorgan Univ Med Sci 2022; 24 (2) :31-40
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Volume 24, Issue 2 (7-2022) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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