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Effect of Endurance Training and Spirulina Supplementation on Inflammatory Cytokines Level in Overweight Men: A Clinical Trial Study
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Ammar Raoufi Sangachin1    , Ahmad Abdi 2, Alireza Barari3 |
1- Ph.D Candidate in Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
2- Associate Professor, Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. , a.abdi@iauamol.ac.ir
3- Associate Professor, Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. |
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Abstract: (1169 Views) |
Background and Objective: Aging and old age are associated with an increase in inflammatory cytokines. Due to their anti-inflammatory properties, constituents of spirulina may be able to reduce or even improve this process. This study was performed to determine the effects of endurance training and spirulina supplementation on the level of inflammatory cytokines in overweight men.
Methods: In this clinical trial, 40 overweight, middle-aged and elderly men were randomly selected and divided into 5 groups: control-normal, control-overweight, overweight + training, overweight + supplement, and overweight + training + supplement. The training program consisting of an hour of walking on a treadmill, stationary bike workout, and climbing stairs was performed at an intensity of 65% of the maximum heart rate, 3 sessions a week, for 8 weeks. Individuals in the supplement groups received a spirulina tablet (500 mg) twice daily in the morning and evening. Blood sampling was performed after 12 hours of fasting at baseline and 48 hours after the last training session. The level of inflammatory cytokines including transforming growth factor-beta (TGF-β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) was measured by enzyme-linked immunosorbent assay.
Results: The levels of TGF-β, IL-6, and TNF-α were higher in the control-overweight group than in the healthy control-normal group (P<0.05). Training and supplementation significantly reduced the inflammatory markers in overweight men (P<0.05). Moreover, the level of inflammatory markers was significantly lower in the training + supplement group compared with the training group and the supplement group (P<0.05).
Conclusion: Endurance training combined with spirulina supplementation can significantly reduce inflammatory factors in overweight individuals.
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Keywords: Endurance Training [MeSH], Spirulina [MeSH], Cytokines [MeSH], Overweight [MeSH]
Article ID: Vol24-15 |
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Full-Text [PDF 824 kb]
(6836 Downloads)
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Type of Study: Original Articles |
Subject:
Exercise Physiology
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Raoufi Sangachin A, Abdi A, Barari A. Effect of Endurance Training and Spirulina Supplementation on Inflammatory Cytokines Level in Overweight Men: A Clinical Trial Study. J Gorgan Univ Med Sci 2022; 24 (2) :1-9 URL: http://goums.ac.ir/journal/article-1-4038-en.html
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