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The study of different treatment therapy in the early stage of Hodgkin’s disease of apper diaphragms in noth-east of Iran
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M.Silaniyan-Toosi (MD) *   1, A.Aledavood (MD) , K.Anvary (MD) |
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Abstract: (20428 Views) |
| Background&Objective: The proper treatment for early-stage Hodgkin’s disease is controversial. The purpose of this study was to evaluate the therapeutic outcomes of various treatment strategies in supradiaphragmatic clinical early-stage Hodgkin’s disease. Materials&Methods: This retrospective study reviewed the medical records of 105 eligible patients (49 stage I, 59 stage II) who were treated at radiotherapy- oncology departments of Qaem and Omid hospitals in Mashhad (Iran) from April 1995 to April 2000. 26 patients had B symptoms and 5 had large mediastinal mass. Treatment of patients consisted of chemotherapy alone (43 cases), radiotherapy alone (46 cases, 40 mantle and 6 Total nodal irradiation) and combined modality (16 cases). Survival rates were calculated by Kaplan- Meier model. Log-rank test was used to compare the survival profile between groups. Results: The median age of patients was 25 years with a male to female ratio of 1.56: 1. In comparison with radiotherapy only group, Primary chemotherapy and combined modality groups had significantly more cases with unfavorable factors such as B symptoms, Large mediastinal mass, ESR>40 and stage II. For chemotherapy, combined modality and radiotherapy groups the 5-year progression free survival was 72.5%, 82.5% and 56.2% (P<0.05) and the 5-year disease specific survival was 82.9%, 91.6% and 82.5% respectively. Conclusion: Despite having more cases with unfavorable factors, patients who underwent chemotherapy or combined treatment had lower relapse rates compared to radiotherapy only group. However, there was not a significant difference in 5-year disease specific survival rates between these groups. |
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| Keywords: Hodgkin’s disease, Supradiaphragmatic, Radiotherapy, Chemotherapy |
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Full-Text [PDF 232 kb]
[English Abstract]
(18151 Downloads)
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Type of Study: Short Communication |
Subject:
General
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| * Corresponding Author Address: Department of Radiotrapy & Oncology Mashhad University of Medical Sciences. mehdi.seilaniantoosi@gmail.com |
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