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:: Volume 23, Issue 1 (3-2021) ::
J Gorgan Univ Med Sci 2021, 23(1): 90-95 Back to browse issues page
Association of TCF7L2 rs7903146 polymorphism with type II diabetes
Rasoul Nasiri Kalmarzi1 , Hossein Mohammadzadea2 , Fatemeh Keshavarzi * 3
1- Associate Professor, Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2- M.Sc in Cellular and Molecular Biology, Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
3- Associate Professor, Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran. , f.keshavarzi@iausdj.ac.ir
Abstract:   (7126 Views)
Background and Objective: Type II diabetes is a major globle health problem that can lead to disability and early death. This study was performed to evaluate the association of TCF7L2 (rs7903146) polymorphism with type II diabetes.
Methods: This case - control study was done on 100 patients with type II diabetes and 100 healthy subjects. Following DNA extraction, TCF7L2 (rs7903146) genotype was determined and compared between two groups by Tetra-Arms PCR method.
Results: The frequency of CT genotype was 25% and 56% in healthy subjects and patients, respectively (P<0.05). The frequency of TT genotype was 2% and 6% in control and patient groups, respectively. In the co-dominant model, rs7903146 was dependent on type II diabetes.
Conclusion: Human heterozygote for Lucos TCF7L2 (rs7903146), which contains T alleles, are high risk for developing diabetes mellitus.
Keywords: Polymorphism [MeSH], Diabetes Mellitus Type 2 [MeSH], TCF7L2 [MeSH]
Article ID: Vol23-11
Full-Text [PDF 633 kb]   (9480 Downloads)    
Type of Study: Original Articles | Subject: Genetic
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Nasiri Kalmarzi R, Mohammadzadea H, Keshavarzi F. Association of TCF7L2 rs7903146 polymorphism with type II diabetes. J Gorgan Univ Med Sci 2021; 23 (1) :90-95
URL: http://goums.ac.ir/journal/article-1-3683-en.html

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Volume 23, Issue 1 (3-2021) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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