Association of TCF7L2 rs7903146 polymorphism with type II diabetes
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Rasoul Nasiri Kalmarzi1 , Hossein Mohammadzadea2 , Fatemeh Keshavarzi * 3 |
1- Associate Professor, Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. 2- M.Sc in Cellular and Molecular Biology, Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran. 3- Associate Professor, Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran. , f.keshavarzi@iausdj.ac.ir |
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Abstract: (7960 Views) |
Background and Objective: Type II diabetes is a major globle health problem that can lead to disability and early death. This study was performed to evaluate the association of TCF7L2 (rs7903146) polymorphism with type II diabetes.
Methods: This case - control study was done on 100 patients with type II diabetes and 100 healthy subjects. Following DNA extraction, TCF7L2 (rs7903146) genotype was determined and compared between two groups by Tetra-Arms PCR method.
Results: The frequency of CT genotype was 25% and 56% in healthy subjects and patients, respectively (P<0.05). The frequency of TT genotype was 2% and 6% in control and patient groups, respectively. In the co-dominant model, rs7903146 was dependent on type II diabetes.
Conclusion: Human heterozygote for Lucos TCF7L2 (rs7903146), which contains T alleles, are high risk for developing diabetes mellitus. |
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Keywords: Polymorphism [MeSH], Diabetes Mellitus Type 2 [MeSH], TCF7L2 [MeSH] Article ID: Vol23-11 |
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Full-Text [PDF 633 kb]
(11096 Downloads)
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Type of Study: Original Articles |
Subject:
Genetic
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