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:: Volume 22, Issue 3 (10-2020) ::
J Gorgan Univ Med Sci 2020, 22(3): 48-55 Back to browse issues page
Comparison of the effect of gabapentin and promethazine as premedication in reducing postoperative pain in tonsillectomy: A clinical trial study
Mahmoud Ganjifard1 , Masoud Madihi2 , Mohammadraza Mofatteh3 , Bibi Fatemeh Shakhs Emampour 4
1- Associate Professor, Department of Anesthesiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
2- General Physician, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
3- Associate Professor, Department of Surgery, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
4- Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran , f.emampour@gmail.com
Abstract:   (5716 Views)
Background and Objective: Pain after tonsillectomy is one of the most common complications. This study was done to compare the effect of Gabapentin and promethazine as premedication to reduce pain after tonsillectomy.
Methods: This clinical trial study was performed on 104 patients aged 7-15 years who were candidate for tonsillectomy. Patients were randomly divided into gabapentin and promethazine groups. The first group received oral gabapentin 20 mg/kg/bw, and the second group was treated with promethazine syrup 0.5 mg/kg/bw one hour before anesthesia. Pain score was recorded based on the MOPS index and recorded and compared during 3, 6, 12, and 24 hours after surgery.
Results: The mean±SD of pain severity in the intervention group with promethazine at 3, 6, 12 and 24 hours after surgery were 1.35±0.84, 0.9±0.87, 0.25±0.52, 0.04±0.19, respectively. Pain severity was 1.58±0.98, 1.13±0.91, 0.69±0.27, and 0.06±0.24 in gabapentin group, respectively. There was no significant difference between pain score of two groups in 3, 6, 12 and 24 hours after surgery.
Conclusion: Gabapentin and promethazine as premedication have a similar analgesic effect in patients after tonsillectomy.
Keywords: Tonsillectomy [MeSH], Gabapentin [MeSH], Promethazine [MeSH], Pain [MeSH]
Article ID: Vol22-37
Full-Text [PDF 305 kb]   (12718 Downloads)    
Type of Study: Original Articles | Subject: Anesthesiology and Pain
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Ganjifard M, Madihi M, Mofatteh M, Shakhs Emampour B F. Comparison of the effect of gabapentin and promethazine as premedication in reducing postoperative pain in tonsillectomy: A clinical trial study. J Gorgan Univ Med Sci 2020; 22 (3) :48-55
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Volume 22, Issue 3 (10-2020) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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