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:: Volume 22, Issue 1 (3-2020) ::
J Gorgan Univ Med Sci 2020, 22(1): 82-87 Back to browse issues page
Prevalancy of cagA and babA of Helicobacter pylori isolated from gastric atrophic patients
Sekineh Safarnejad1 , Amin Talebi Bezmin Abadi * 2
1- M.Sc Student in Medical Bacteriology, Department of Bacteriology, Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2- Assistant Professor, Department of Bacteriology, Medical Sciences, Tarbiat Modares University, Tehran, Iran , amin.talebi@modares.ac.ir
Abstract:   (8589 Views)
Background and Objective: The infection of Helicobacter pylori (H. pylori) is one of the most complex items addressed in the clinical microbiology. Although H. pylori positive subjects are bound to develop into atrophic gastritis, current body of evidences is rare. Due to the high prevalence of this bacterium worldwide, finding the true virulence factors as biomarkers for severe gastroduodenal diseases was the priority in recent researches. This study was carried out to determine the prevalancy of cagA and babA of Helicobacter pylori isolated from gastric atrophic patients.
Methods: This descriptive – analytical study was conducted on 100 patients with gastroduodenal disorders in Labafinejad hospital in Tehran, Iran during 2018. Identification of each patient and also bacterial isolation were undertaken according to the standard protocols.
Results: H. pylori were isolated in 23% of patients. 10 patients affected by atrophic gastritis followd by gastric ulcer (7 patients) and acute gastritis (6 patients). In totally, the rate of cagA gene and babA in H. pylori isolated with positive results was 52% and 34%, respectively. There was a significant association between the presence of cagA positive strains and patients with gastric atrophic (P<0.05). The babA gene did not correlate with the presence of gastric atrophic patients.
Conclusion: This study showed that various carrying cagA positive H. pylori can be recovered from patients with gastric atrophy.

Keywords: Helicobacter pylori, cagA, babA, Gastric cancer, Gastric atrophy
Article ID: Vol22-12
Full-Text [PDF 198 kb]   (12710 Downloads)    
Type of Study: Original Articles | Subject: Microbiology
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Safarnejad S, Talebi Bezmin Abadi A. Prevalancy of cagA and babA of Helicobacter pylori isolated from gastric atrophic patients. J Gorgan Univ Med Sci 2020; 22 (1) :82-87
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Volume 22, Issue 1 (3-2020) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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