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:: Volume 21, Issue 4 (Winter 2020) ::
J Gorgan Univ Med Sci 2020, 21(4): 14-21 Back to browse issues page
Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study
Javad Almasi1 , Kamal Azizbeigi * 2, Khaled Mohammad Zade Salamat3 , Behshad Naghshtabrizi4 , Mohammad Ali Azarbayjani5
1- Ph.D Candidate in Exercise Physiology, Physical Education Department, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
2- Associate Professor of Exercise Physiology, Physical Education Department, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran , kazizbeigi@gmail.com
3- Assistant Professor of Exercise Physiology, Physical Education Department, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
4- Cardiologist, Associate Professor, Hamadan University of Medical Sciences, Hamadan, Iran
5- Professor of Exercise Physiology, Exercise Physiology Department, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (1455 Views)
Background and Objective: Todays, coronary artery disease is one of the most important health issues. Antioxidants are the agents that can play important role in reducing cardiovascular diseases. The present study was done to determine the effect of resveratrol supplementation during rehabilitation exercises training on systemic inflammation factors in patients after coronary artery bypass surgery.
Methods: This clinical trial study was done on 40 patients after coronary artery bypass surgery in the heart rehabilitation center of Farshchian cardiovascular specialist hospital in Hamadan, Iran during 2016. Patients randomly assigned into four groups including control (Con; n=10), resveratrol supplementation (RS; n=10), rehabilitation exercise training (RXT; n=10), and resveratrol supplements-cardiac rehabilitation exercise training (REX; n=10). Rehabilitation exercise training was done in nonconsecutive three sessions for eight weeks in the form of endurance training at 50-70% HRmax for 15-20 min, and resistance training at 20-50 one-repetition maximum (1RM). The number of repetitions was 8-15 reps, where done based on the capacity and ability of the subject, while the subjects in supplement groups consumed daily 400 mg of resveratrol. Blood sample was done before and 48 hours after exercise training and supplementation, and concentrations of Tumor necrosis factor alpha (TNFα), Interleukin- 6 (IL-6), Interleukin 1 beta (IL-1β) and C-reactive protein (CRP) were measured in the plasma.
Results: CRP, TNF-alpha and IL-1beta and IL-6 were significantly reduced in resveratrol supplements-cardiac rehabilitation exercise training group in compared to control, resveratrol supplementation and rehabilitation exercise training groups (P˂0.05).
Conclusion: This study showed that combination of consuming resveratrol with rehabilitation exercise training in reducing some inflammatory factors was evaluated selectively, more effective than rehabilitation exercise training and resveratrol supplementation alone.
Keywords: Coronary artery bypass surgery, Resveratrol, rehabilitation exercise training, Interleukin- 6, C-reactive protein
Full-Text [PDF 252 kb]   (245 Downloads)    
Type of Study: Original Articles | Subject: Cardiovascular
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Almasi J, Azizbeigi K, Mohammad Zade Salamat K, Naghshtabrizi B, Azarbayjani M A. Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study. J Gorgan Univ Med Sci. 2020; 21 (4) :14-21
URL: http://goums.ac.ir/journal/article-1-3488-en.html


Volume 21, Issue 4 (Winter 2020) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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