[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Aim and Scope
Content Coverage
Ethics
Conflict of Interest
Copyrights & License
Price
Indexing Sources::
Editorial Board::
Executive Members::
Articles Archive::
Current Issue
All Issues
Instruction to Authors::
Peer-Review::
Contact Us::
Contact Us
Contact Form
Site Facilities::
Search contents
::
Search in website

Advanced Search
Receive site information
Enter your Email in the following box to receive the site news and information.
:: Volume 21, Issue 4 (12-2019) ::
J Gorgan Univ Med Sci 2019, 21(4): 14-21 Back to browse issues page
Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study
Javad Almasi1 , Kamal Azizbeigi 2, Khaled Mohammad Zade Salamat3 , Behshad Naghshtabrizi4 , Mohammad Ali Azarbayjani5
1- Ph.D Candidate in Exercise Physiology, Physical Education Department, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
2- Associate Professor of Exercise Physiology, Physical Education Department, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran , kazizbeigi@gmail.com
3- Assistant Professor of Exercise Physiology, Physical Education Department, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
4- Cardiologist, Associate Professor, Hamadan University of Medical Sciences, Hamadan, Iran
5- Professor of Exercise Physiology, Exercise Physiology Department, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract:   (7382 Views)
Background and Objective: Todays, coronary artery disease is one of the most important health issues. Antioxidants are the agents that can play important role in reducing cardiovascular diseases. The present study was done to determine the effect of resveratrol supplementation during rehabilitation exercises training on systemic inflammation factors in patients after coronary artery bypass surgery.
Methods: This clinical trial study was done on 40 patients after coronary artery bypass surgery in the heart rehabilitation center of Farshchian cardiovascular specialist hospital in Hamadan, Iran during 2016. Patients randomly assigned into four groups including control (Con; n=10), resveratrol supplementation (RS; n=10), rehabilitation exercise training (RXT; n=10), and resveratrol supplements-cardiac rehabilitation exercise training (REX; n=10). Rehabilitation exercise training was done in nonconsecutive three sessions for eight weeks in the form of endurance training at 50-70% HRmax for 15-20 min, and resistance training at 20-50 one-repetition maximum (1RM). The number of repetitions was 8-15 reps, where done based on the capacity and ability of the subject, while the subjects in supplement groups consumed daily 400 mg of resveratrol. Blood sample was done before and 48 hours after exercise training and supplementation, and concentrations of Tumor necrosis factor alpha (TNFα), Interleukin- 6 (IL-6), Interleukin 1 beta (IL-1β) and C-reactive protein (CRP) were measured in the plasma.
Results: CRP, TNF-alpha and IL-1beta and IL-6 were significantly reduced in resveratrol supplements-cardiac rehabilitation exercise training group in compared to control, resveratrol supplementation and rehabilitation exercise training groups (P˂0.05).
Conclusion: This study showed that combination of consuming resveratrol with rehabilitation exercise training in reducing some inflammatory factors was evaluated selectively, more effective than rehabilitation exercise training and resveratrol supplementation alone.
Keywords: Coronary artery bypass surgery, Resveratrol, rehabilitation exercise training, Interleukin- 6, C-reactive protein
Full-Text [PDF 252 kb]   (12912 Downloads)    
Type of Study: Original Articles | Subject: Cardiovascular
References
1. Martinez AM, Sordia-Hernnndez LH, Morales JA, Merino M, Vidal O, García Garza MR, et al. A randomized clinical study assessing the effects of the antioxidants, resveratrol or SG1002, a hydrogen sulfide prodrug, on idiopathic oligoasthenozoospermia. Asia Pacific Journal of Reproduction. 2015 Jun; 4(2): 106-11. https://doi.org/10.1016/S2305-0500(15)30005-1
2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005 Apr; 352(16): 1685-95. doi: 10.1056/NEJMra043430
3. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999 Jan; 340(2): 115-26. doi: 10.1056/NEJM199901143400207
4. Black S, Kushner I, Samols D. C-reactive Protein. J Biol Chem. 2004 Nov; 279(47): 48487-90. doi: 10.1074/jbc.R400025200
5. Thompson D, Pepys MB, Wood SP. The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure. 1999 Feb; 7(2): 169-77. doi: 10.1016/S0969-2126(99)80023-9
6. Lacina L, Brábek J, Král V, Kodet O, Smetana K Jr. Interleukin-6: a molecule with complex biological impact in cancer. Histol Histopathol. 2019 Feb; 34(2): 125-36. doi: 10.14670/HH-18-033
7. Gulhar R; Jialal I. Physiology, Acute Phase Reactants. Treasure Island (FL): StatPearls Publishing. 2019 Jan.
8. Olmos G, Lladó J. Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediators Inflamm. 2014; 2014: 861231. doi: 10.1155/2014/861231
9. Zordoky BN, Robertson IM, Dyck JR. Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. Biochim Biophys Acta. 2015 Jun; 1852(6): 1155-77. doi: 10.1016/j.bbadis.2014.10.016
10. Fishbein MC, Fishbein GA. Arteriosclerosis: facts and fancy. Cardiovasc Pathol. 2015 Nov-Dec; 24(6): 335-42. doi: 10.1016/j.carpath.2015.07.007
11. Shi XZ, Lindholm PF, Sarna SK. NF-kappa B activation by oxidative stress and inflammation suppresses contractility in colonic circular smooth muscle cells. Gastroenterology. 2003 May; 124(5): 1369-80.
12. Frankel EN, Waterhouse AL, Kinsella JE. Inhibition of human LDL oxidation by resveratrol. Lancet. 1993 Apr; 341(8852): 1103-4. doi: 10.1016/0140-6736(93)92472-6
13. Petrovski G, Gurusamy N, Das DK. Resveratrol in cardiovascular health and disease. Ann N Y Acad Sci. 2011 Jan; 1215: 22-33. doi: 10.1111/j.1749-6632.2010.05843.x
14. Bellet RN, Adams L, Morris NR. The 6-minute walk test in outpatient cardiac rehabilitation: validity, reliability and responsiveness--a systematic review. Physiotherapy. 2012 Dec; 98(4): 277-86. doi: 10.1016/j.physio.2011.11.003
15. Brzycki M. Strength testing: predicting a one – rep max from repetitions-to-fatigue. J Phys Educ Recreat Dance. 1993; 64(1): 88-90. https://doi.org/10.1080/07303084.1993.10606684
16. Anderson L, Thompson DR, Oldridge N, Zwisler AD, Rees K, Martin N, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2016 Jan; (1): CD001800. doi: 10.1002/14651858.CD001800.pub3
17. Baltaci SB, Mogulkoc R, Baltaci AK. Resveratrol and exercise. Biomed Rep. 2016 Nov; 5(5): 525-30. doi: 10.3892/br.2016.777
18. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun; 14(2): 141-53.
19. West RR, Jones DA, Henderson AH. Rehabilitation after myocardial infarction trial (RAMIT): multi-centre randomised controlled trial of comprehensive cardiac rehabilitation in patients following acute myocardial infarction. Heart. 2012 Apr; 98(8): 637-44. doi: 10.1136/heartjnl-2011-300302
20. Peake J, Nosaka K, Suzuki K. Characterization of inflammatory responses to eccentric exercise in humans. Exerc Immunol Rev. 2005; 11: 64-85.
21. Liu X, Tian J, Bai Q, Ashraf MA, Sarfraz M, Zhao B. The effect and action mechanism of resveratrol on the vascular endothelial cell by high glucose treatment. Saudi J Biol Sci. 2016 Jan; 23(1): S16-21. doi: 10.1016/j.sjbs.2015.06.021
22. Kim EN, Kim MY, Lim JH, Kim Y, Shin SJ, Park CW, et al. The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. Atherosclerosis. 2018 Mar; 270: 123-31. doi: 10.1016/j.atherosclerosis.2018.01.043
23. Xie C. Resveratrol does not reduce CVD risk, prolong life - A statistical point of view. Contemp Clin Trials Commun. 2015 Oct; 1:1. doi: 10.1016/j.conctc.2015.08.004
24. Zhu Y, Feng B, He S, Su Z, Zheng G. Resveratrol combined with total flavones of hawthorn alleviate the endothelial cells injury after coronary bypass graft surgery. Phytomedicine. 2018 Feb; 40: 20-26. doi: 10.1016/j.phymed.2017.12.037
25. Gaeini AA , Satarifard S, Heidary A. Comparing the effect of eight weeks of high-intensity interval training and moderate-intensity continuous training on physiological variables of exercise stress test in cardiac patient after coronary artery bypass graft. J Isfahan Med Sch. 2014, 31(267): 2171-81.
26. Malekyian-Fini E, Kaviani-Nia A, Mahmoudi F. [The interactive effect of aerobic training and resveratrol supplementation on C-reactive protein and metabolic profiles in women with type 2 diabetes]. Feyz. 2015; 19(5): 372-81. [Article in Persian]
Send email to the article author

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Almasi J, Azizbeigi K, Mohammad Zade Salamat K, Naghshtabrizi B, Azarbayjani M A. Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study. J Gorgan Univ Med Sci 2019; 21 (4) :14-21
URL: http://goums.ac.ir/journal/article-1-3488-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 4 (12-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 36 queries by YEKTAWEB 4645