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:: Volume 21, Issue 3 (10-2019) ::
J Gorgan Univ Med Sci 2019, 21(3): 34-40 Back to browse issues page
Effect of combined Ondansetron and Apotel on control of the post-operative pain after surgery of upper limb fractures: A clinical trial study
Salehe Akhondi1 , Fatemeh Mehravar2 , Faranak Rokhtabnak3 , Omid Momen4 , Seyed Babak Mojaveraghili * 5
1- Resident of Anesthesiology, Clinical Research Development Unit (CRDU), 5Azar Hospital, Faculty of Medicin, Golestan University of Medical Sciences, Gorgan, Iran
2- Ph.D Candidate in Epidemiology, Health Management and Social Development Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3- Assistant Professor of Anesthesiology, Faculty of Medicin, Iran University of Medical Sciences, Tehran, Iran
4- Assistant Professor of Orthopaedics, Faculty of Medicin, Golestan University of Medical Sciences, Gorgan, Iran
5- Assistant Professor of Anesthesiology, Faculty of Medicin, Golestan University of Medical Sciences, Gorgan, Iran , drbabaka35@gmail.com
Abstract:   (9370 Views)
Background and Objective: Control of postoperative pain is one of the most important stages in the recovery of patients after surgery. This study was done to compare the effectiveness of combined Ondansetron and Apotel on the post-operative pain after surgery of upper limb fractures.
Methods: This double blind clinical trial study was done on 50 individual (41 male and 9 female) with upper limb fractures referring to 5 Azar hospital in Gorgan northern Iran during 2017. Patients were assigned (block randomization) into control and intervention groups. After the end of operation in the recovery phase, both groups received pain PCA (Patient Controlled Analgesia). In control group, the pain pump consisted of 2 grams of Apotel and in the intervention group; the pain pump consisted of 2 grams Apotel and 8 mg of ondansetron. Visual Analogue Score (VAS) was evaluated in both groups after surgery for 24 hours. Pain score of patients compared in the 2 groups during the 3 time intervals after surgery.
Results: 4 hours after upper limb fracture surgery, the mean pain was significantly decreased in the intervention group (3.20±0.707) compared to control group (3.64±0.569) (P<0.05). 12 hours after upper limb fracture surgery The Mean pain, in the intervention group (1.88±0.927) was significantly reduced in compare to control group (2.64±1.186) (P<0.05). 24 hours after upper limb fracture surgery, The Mean pain was significantly reduced in the intervention group (1.40±0.645) in compare to control group (2.08±0.997) (P<0.05).
Conclusion: This study showed that administration of compination of Apotele and Ondansetron in post-operative pain of upper limb fractures is effective than apotele alone.
Keywords: Surgery, Upper limb fractures, Ondansetron, Apotel, Acetaminophen, Pain, General anaesthesia
Full-Text [PDF 269 kb]   (11266 Downloads)    
Type of Study: Original Articles | Subject: Anesthesiology and Pain
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Akhondi S, Mehravar F, Rokhtabnak F, Momen O, Mojaveraghili S B. Effect of combined Ondansetron and Apotel on control of the post-operative pain after surgery of upper limb fractures: A clinical trial study. J Gorgan Univ Med Sci 2019; 21 (3) :34-40
URL: http://goums.ac.ir/journal/article-1-3431-en.html


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Volume 21, Issue 3 (10-2019) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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