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:: Volume 20, Issue 1 (3-2018) ::
J Gorgan Univ Med Sci 2018, 20(1): 90-95 Back to browse issues page
Frequncey of PDCD1.3 gene polymorphisms in systemic lupus erythematosus patients
Yousef Khanjari1 , Alijan Tabarraei 2, Morteza Oladnabi3 , Nafiseh Abdolahi4
1- M.Sc in Virology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Associate Professor, Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran. tabarraei@goums.ac.ir , tabarraei@goums.ac.ir
3- Assistant Professor, Gorgan Congenital Malformations Research Center, Department of Human Genetics, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran
4- Assistant Professor, Rheumatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Abstract:   (15279 Views)
Background and Objective: Single Nucleotide Polymorphisms in programmed cell death which expressed at high level in T cells, plays an important role in the development and cause autoimmune disorders. This study was done to evaluate the frequncy of rs11568821 polymorphism in patients with systemic lupus erythematosus (SLE).
Methods: This case-control study was done on 76 patients with SLE and 56 healthy controls. After DNA extraction, frequncy of polymorphisms PDCD1.3 by polymerase chain reaction and sequencing methods in subjects were determined.
Results: There was a significant diference between frequency of allele and genotype at rs11568821 Polymorphism in region of intron 4 of PDCD1.3 gene in case and control groups (P<0.05). A allele and AG genotype was significantly higher in patients than healthy controls (9.5% vs 0.09%, P<0.05). There was no significant association between clinical and laboratory findings with genotype frequencies.
Conclusion: rs11568821 single nucleotide polymorphism in intron 4 gene region PDCD1 can be used as a genetic factor to be involved the SLE susceptibility.
Keywords: Systemic lupus erythematosus, PDCD1.3, Sequencing methods, Single Nucleotide Polymorphisms, Polymerase chain reaction
Full-Text [PDF 266 kb] [English Abstract]   (9093 Downloads) |   |   Abstract (HTML)  (542 Views)  
Type of Study: Original Articles | Subject: Internal Medicine
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Khanjari Y, Tabarraei A, Oladnabi M, Abdolahi N. Frequncey of PDCD1.3 gene polymorphisms in systemic lupus erythematosus patients . J Gorgan Univ Med Sci 2018; 20 (1) :90-95
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Volume 20, Issue 1 (3-2018) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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