Effect of creatine supplementation on creatine kinase and lactate dehydrogenase enzymes following a severe muscle contraction in female athletes: A clinical trial study

Sedaghat , Mahsa; Rashidi , Mohammad

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Volume 21, Issue 1 (3-2019)

J Gorgan Univ Med Sci 2019, 21(1): 1-6

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Effect of creatine supplementation on creatine kinase and lactate dehydrogenase enzymes following a severe muscle contraction in female athletes: A clinical trial study

Mahsa Sedaghat ^*

¹, Mohammad Rashidi²

1- Academic Instrcrutor, Department of Physical Education, Semnan Branch, Islamic Azad University, Semnan, Iran , sedaghat.mahsa61@gmail.com
2- Assistant Professor, Department of Physical Education, Semnan Branch, Islamic Azad University, Semnan, Iran

Abstract: (10912 Views)

Background and Objective: Creatine is one of the most important and commonly used supplements athletes, although the molecular mechanisms of creatine and its side effects are less understood. The high level of the ceratin kinase enzyme and lactate dehydrogenase enzymes are considered to be a sign of cell damage. This study was done to determine the effect of creatine monohydrate supplementation on creatine kinase (CK) and lactate dehydrogenase (LDH) enzymes following a severe muscle contraction in female athletes.
Methods: In this double-blind clinical trial study, 30 female athletes were randomly divided into intervention (creatine supplementation 0.3 grams per body weight for 4 times duing 7 days and control (placebo, starch powder) groups. Blood sample was collected before supplementation (pre-test) and 24 hours after Cunningham exercise test (post-test) to measuring CK and LDH in each subject.
Results: After intervention, the level of CK (323±63 IU/L) and LDH (119±13 IU/L) in intervention group had no significant difference in compared to control group (CK: 328±44 IU/L and LDH: 122±14 IU/L).
Conclusion: The usage of a 7-day course of creatine supplement did not significantly change the CK and LDH levels following a severe muscle contraction in female athletes.

Keywords: Creatine supplement, Creatine kinase, Lactate dehydrogenase, Severe muscle contraction, Athlete

Full-Text [PDF 196 kb] (21011 Downloads)

Type of Study: Original Articles | Subject: Exercise Physiology

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Sedaghat M, Rashidi M. Effect of creatine supplementation on creatine kinase and lactate dehydrogenase enzymes following a severe muscle contraction in female athletes: A clinical trial study. J Gorgan Univ Med Sci 2019; 21 (1) :1-6
URL: http://goums.ac.ir/journal/article-1-3246-en.html

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