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:: Volume 19, Issue 4 (12-2017) ::
J Gorgan Univ Med Sci 2017, 19(4): 46-53 Back to browse issues page
Evaluation of accuracy of diagnosis of lipid accumulate product index, insulin resistance, waist circumference and waist to hip ratio in women with polycystic ovary syndrome
Elham Zarei1 , Hassan Mohajery Shahrebabaki1 , Fatemeh Mohammad Zadeh2 , Sepideh Bakhshandeh Nosrat3 , Azad Reza Mansourian * 4
1- M.Sc in Biochemistry, Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2- AssistantProfessor, Departmentof Internal Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3- Associate Professor, Departmentof Gynecology, Golestan University of Medical Sciences, Gorgan, Iran
4- Professor, Metabolic Disorder Research Center, Department of Biochemistry, Golestan University of Medical Sciences, Gorgan, Iran , azad_r_mansourian@yahoo.com
Abstract:   (10459 Views)
Background and Objective: Polycystic Ovarian Syndrome (PCOS) is considered as a metabolic disorder and it is one of the most common endocrine and heterogeneous disorders with complex pathogenesis among women in reproductive ages. This study was done to evaluate the accuracy of diagnosis of lipid accumulate product index (LAP), insulin resistance, waist circumference and waist to hip ratio in women with polycystic ovary syndrome.
Methods: In this case control study, antropometrics, biochemical parameters, LAP and insulin resistance in 43 women suffering from PCOS as case and 40 healthy women as control were measured. Body mass index (BMI), waist hip ratio (WHR) and waist circumference (WC) was determined for each subject. LAP was defined as [WC (cm)-58´TG (m mol/L)]. PCOS was diagnosed according to Roterdam standard .Insulin resistance was defined based on Homeostatic model assessment – insulin resistance (HOMA-IR).
Results: The mean age, BMI, WHR and LAP index, among PCOS women were 24.06±5.86, 26.61±4.34, 0.81±0.061 and 47.13±4.13, respectively. There was a direct and significant correlation between HOMA-IR index and BMI, WC and LAP in case group (P<0.05). Statistical analysis showed that the optimal cut-off value of LAP, BMI, WC and WHR were 46.93, 27.91, 93 and 0.81 respectively.
Conclusion: The WC, BMI and LAP indices are useful in screening the insulin resistance in patients with PCOS.
Keywords: Polycystic ovary syndrome, Insulin resistance index, lipid accumulate product index, Waist to hip ratio, Body mass index, Waist circumference
Full-Text [PDF 280 kb] [English Abstract]   (16037 Downloads) |   |   Abstract (HTML)  (851 Views)  
Type of Study: Original Articles | Subject: Internal Medicine
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Zarei E, Mohajery Shahrebabaki H, Mohammad Zadeh F, Bakhshandeh Nosrat S, Mansourian A R. Evaluation of accuracy of diagnosis of lipid accumulate product index, insulin resistance, waist circumference and waist to hip ratio in women with polycystic ovary syndrome. J Gorgan Univ Med Sci 2017; 19 (4) :46-53
URL: http://goums.ac.ir/journal/article-1-3215-en.html
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Volume 19, Issue 4 (12-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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