Background & Objective: In spit of high prevalancey of the Obsessive-Compulsive Disorder in anxity diseases. It shows the least therapeutic responses. This study was done to determine The comparison of therapeutic effect of Naltrexone and Flouxetine on Obsessive-Compulsive Disorder (O.C.D).

Materials & Methods: This double-blind clinical trial study was done on 30 patients aged 18 to 60 years referring to the clinics of psychiatry at Zareh hospital in Sari-Iran during 2006. Patients in three groups, treated with flouxetine 53.9mg/d (group A) Naltrexone 64.4mg/d (groupe B) & Pelacebo (group C) in the same shape capsula respectively. The severity of O.C.D was evaluated at 4 steps with Yale-Brown scale.the obtained data were analyzed using parametric & nonparametric tests.

Results: Naltrexone reduced the severity of O.C.D symptoms significantly (45.01%) at the end of week 8^th (p<0.05). Same result (45.81%) was observed using Flouxetine (P=0.79). The rate of efficaey in both drugs significantly was higher than pelacebo (P<0.05).

Conclusion: This study showed thant, Naltrexone has the same level of reducting symptome of OCD but even with faster therapeutic effect than Flouxetin.