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:: Volume 18, Issue 1 (3-2016) ::
J Gorgan Univ Med Sci 2016, 18(1): 94-100 Back to browse issues page
Association of C/T polymorphism in 3´UTR of E-cadherin gene with ovarian cancer risk
Heydari Ashrafi M1 , Onsory Kh * 2, Naseh V3
1- M.Sc in Developmental Biology, Biology Department, Parand Branch, Islamic Azad University, Parand, Iran
2- Assistant Professor, Ph.D in Molecular Genetics, Biology Department, Parand Branch, Islamic Azad University, Parand, Iran , onsory@gmail.com
3- Assistant Professor, Ph.D in Veterinary Physiology, Biology Department, Parand Branch, Islamic Azad University, Parand, Iran
Abstract:   (12406 Views)

Background and Objective: Ovarian cancer is the second most common gynecological malignancy. One of the most important genes in Wnt signaling pathway is E-cadherin (CDH1), which is involved in epithelial cell-cell interaction and plays an important role in the establishment and maintenance of intercellular adhesion, cell polarity and tissue architecture. E-cadherin codes a group of connector proteins which caused to intercellular adhesion. It has an important role in adhesion of blastomere and ability to bind fetal tissues. Nucleotide change in the coding region of this gene may lead to develop ovarian cancer. This study was conducted to evaluate the association of +54C/T (Rs1801026) 3΄UTR of E-cadherin gene polymorphism with ovarian cancer risk. Methods: This case-control study was done on 100 tissue samples of patients with ovarian cancer as cases and 100 age-matched healthy women as control in Imam Khomeini Hospital, Tehran, Iran. The E-cadherin gene polymorphism was determined by using the PCR-RFLP method. Results: There was no association between CT (95% CI: 0.81-4.31; OR=1.87; P<0.14) and TT (95% CI: 0.73-2.38; OR=1.44; P<0.29) genotypes and ovarian cancer. No association was found between genotypes with grade and stage of cancer. Conclusion: There is no correlation between +54C/T (Rs1801026) 3΄UTR of E-cadherin gene polymorphism with ovarian cancer.
Keywords: Ovarian cancer, E-cadherin gene, Polymorphism, PCR
Full-Text [PDF 214 kb] [English Abstract]   (20007 Downloads) |   |   Abstract (HTML)  (332 Views)  
Type of Study: Original Articles | Subject: Oncology
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Heydari Ashrafi M, Onsory Kh, Naseh V. Association of C/T polymorphism in 3´UTR of E-cadherin gene with ovarian cancer risk. J Gorgan Univ Med Sci 2016; 18 (1) :94-100
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Volume 18, Issue 1 (3-2016) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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