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Effect of a session resistance exercise on mRNA expression of NT-3 and TrkC proteins in soleus muscle of Wistar rats
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Eslami R   1, Gharakhanlou R2 , Kazemi AR3 , Dabaghzadeh R4 |
1- Ph.D in Exercise Physiology, Department of Exercise Physiology, Kerman Branch, Islamic Azad University, Kerman, Iran , r_eslami1000@yahoo.com
2- Associate Professor, Department of Physical Education, Faculty of Humanity, Tarbiat Modares University, Tehran, Iran
3- Assistant Professor, Department of Physical Education, Vali-e-Asr Rafsanjan University, Rafsanjan, Iran
4- M.Sc Student in Exercise Physiology, Kerman Branch, Islamic Azad University, Kerman, Iran |
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Abstract: (10397 Views) |
| Background and Objective: Skeletal muscle expresses several neurotrophin and their receptors which providing the basis for neurotrophin signaling within the muscle compartments. This study was done to evaluate the effect of a session of resistance exercise on mRNA expression of NT-3 and TrkC proteins in soleus muscle of Wistar Rats. Methods: In this experimental study, 16 male Wistar rats were randomly allocated into exercise and control groups. The resistance training protocol consisted of climbing a 1-meter–long ladder, with a weight attached to a tail sleeve. Expressions of NT-4/5 and P75, quantitatively were measured using RT-PCR. Results: There was not any significant alteration in NT-3 mRNA in soleus muscle after resistance exercise. However, one session of resistance exercise significantly increased mRNA expression of TrkC (1.7 Folds) in soleus muscle (P<0.05). Conclusion: Resistance exercise increases TrkC expression in soleuse muscle of wistar rats. |
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| Keywords: Soleus muscle, Resistance exercise, Neurotrophin-3 (NT-4/5), TrkC receptor, Rat |
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Full-Text [PDF 192 kb]
[English Abstract]
(14477 Downloads)
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Type of Study: Original Articles |
Subject:
Genetic
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