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Association of Interleukin-18 gene polymorphism -137G/C with Allergic rhinitis
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Ramazi Sh1   , Khazraei HR * 2, Motovalibashi M3 , Iziy E4 , Hashemzade Chaleshtori M5 , Abolhassani M6 |
1- Ph.D Candidate in Genetic, Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2- Assistant Professor, Department of Otolaryngology, Shahrekord University of Medical Sciences, Shahrekord, Iran , a1hamid@yahoo.com
3- Associate Professor, Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
4- M.Sc in Cellular and Developmental, Traditional and Complementary Medicine Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
5- Professor, Department of Genetic, Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
6- B.Sc in Genetic, Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran |
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Abstract: (13587 Views) |
| Background and Objective: The interleukin-18 (IL-18) gene on chromosome 11 has been suggested as a susceptibility factor for allergies. It is a member of the IL-1 family that was originally described as interferon (IFN-γ)–inducing factor. IL-18 might initiate Th2 responses with production of IgE via the stimulation of IL-4 and IL-13 synthesis in mast cells and in basophil and eosinophil recruitment, such as allergic inflammation. This study was done to assess the association of Interleukin-18 gene polymorphism -137G/C with allergic rhinitis. Methods: This case-control study was performed on 293 allergic rhinitis patients and 218 healthy control volunteers .The IL-18 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the GG, GC and CC genotypes were 64.2%, 32.1% and 3.7% in healthy controls and 60.1%, 35.5% and 4.4% in allergic rhinitis patients, respectively. This diference was not significant. Conclusion: This study suggests that IL-18 polymorphism gene -137G/C may not be participated as a risk factor in the pathogenesis of allergic rhinitis. |
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| Keywords: Allergic rhinitis, Interleukin-18, Polymorphism |
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Full-Text [PDF 196 kb]
[English Abstract]
(18353 Downloads)
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Type of Study: Original Articles |
Subject:
Genetic
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