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:: Volume 16, Issue 1 (3-2014) ::
J Gorgan Univ Med Sci 2014, 16(1): 42-48 Back to browse issues page
Palmatine hydrochloride improves motor dysfunction in streptozotocin-induced diabetic rats
Ahouei M * 1, Vaezi Gh2 , Kalalian Moghaddam H3
1- Physiologist , ahouee@yahoo.com
2- Associated Professor, Department of Biology, Faculty of Basic Science, Damghan Branch, Islamic Azad University, Damghan, Iran
3- Assistant Professor, Department of Physiology, Faculty of Medicine, Shahrood University of Medical Sciences, Shahroud, Iran
Abstract:   (20495 Views)
Background and Objective: Diabetes induces motor dysfunctions, Palmatine is an isoquinoline alkaloid, with anti-diabetic and antioxidant activities. This study was conducted to evaluate the effect of Palmatine on motor dysfunction in STZ-induced diabetic rats. Materials and Methods: In this experimental study, 32 male wistar rats were randomly allocated into control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg/bw, intraperitoneally. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/bw per day for a period of 6 weeks, one week after induction of diabetes. Blood glucose level was measured 1, 3, 5, 7 weeks after STZ injection. Locomotor activity tests including Y maze, grip-traction and inclined plane tests were performed to determining locomotor activity. Results: In Y maze test, the number of arms entered significantly increased in Palmatine-treated diabetic group compared to diabetic group (P<0.05). Grip traction and inclined plane tests significantly increased in Palmatine-treated diabetic group compared to diabetics animals (P<0.05). Conclusion: Palmatine hydrochloride administration for 6 weeks improves motor dysfunctions in streptozotocin-induced diabetic rats.
Keywords: Diabetes mellitus, Palmatine hydrochloride, Motor dysfunctions, Streptozotocin, Rat
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Type of Study: Original Articles | Subject: Physiology - Pharmacology
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Ahouei M, Vaezi Gh, Kalalian Moghaddam H. Palmatine hydrochloride improves motor dysfunction in streptozotocin-induced diabetic rats. J Gorgan Univ Med Sci 2014; 16 (1) :42-48
URL: http://goums.ac.ir/journal/article-1-1972-en.html
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Volume 16, Issue 1 (3-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی گرگان Journal of Gorgan University of Medical Sciences
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)