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Effect of Kombucha tea on rat liver histophatological alterations due to Thioacetamide
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Kabiri N *1   , Ahangar Darabi M2 , Mahzooni P3 |
1- MSc in Biology, Shahrekord University of Medical Sciences, Shahrekord, Iran , kabiri_s97@yahoo.com
2- MSc in Biology, Department of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran
3- Associate Professor, Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran |
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Abstract: (14944 Views) |
| Background and Objective: Kombucha (fungal) tea is a sugar sweetened black tea obtained through a fermentation process containing symbiotic culture of acetic acid bacteria and yeasts. This study was done to determine the effect of Kombucha tea on rat liver histophatological alterations due to Thioacetamide (TAA). Materials and Methods: In this experimental study, 20 adult male Wistar rats randomly allocated into four groups as follow: 1) control, 2) TAA group, treated with (TAA), (400 mg/kg/bw) for two weeks, 3) treated with (TAA), (400 mg/kg/bw) and then with Kombucha tea (50 mg/kg) and finally 4) preventive, treated with Kombucha tea, (50 mg/kg) and then (TAA), (400 mg/kg) for three weeks. The serum level of aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and total bilirubin were meseared and liver tissue samples were stained by hematoxilin and eosin. Results: Serum level of AST, ALT, ALP, LDH and total bilirubin significantly increased in TAA group compare to control group (P<0.05). Serum level of AST, ALT, ALP, LDH and total bilirubin significantly reduced in treated and protective groups in comparision with TAA group (P<0.05). Mitosis and apptosis increased in TAA group. These liver histopathological alterations reduced in terated and protective groups. Conclusion: Kombucha tea contains theraputic and protective effects on enzyms and liver histophatological damage due to Thioacetamide in rat. |
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| Keywords: Kombucha tea, Thioacetamide, Liver, Enzym, Rat |
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Full-Text [PDF 717 kb]
[English Abstract]
(27403 Downloads)
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Type of Study: Original Articles |
Subject:
Pathology
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