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The Simultaneous Effect of Linum Usitatissimum Supplementation and Aerobic Training on 6-Methylguanine and ATP in the Endothelial Aorta and Heart Tissues in Rats Poisoned with H2O2
Seyed Mostafa Rezaei, Bahram Abedi, Hoseyn Fatolahi,
Volume 9, Issue 3 (10-2021)
Abstract
Background and Objective: As a high-energy demanding tissue, the heart is exposed to a high level of ROS molecules such as H2O2, leading to cardiovascular disorders through damaging macromolecules such as DNA and disrupting ATP production. Hence, this study aimed to investigate the simultaneous effect of aerobic exercise (Ae) and Linum Usitatissimum (Lu) supplementation on DNA damage and ATP synthesis in heart and aorta endothelial tissues in rats poisoned with hydrogen peroxide (H2O2).
Material and Methods: 56 male Wistar Albino rats were randomly divided into 7 groups, including HC (Healthy Control), TC (Toxicated Control), Lu1 (Received 5 mg/kg of Lu), Lu2 (Received 10 mg/kg of Lu), Ae (Received only Aerobic Exercise), Ae Lu1, and Ae Lu2. Then, all groups got poisoned by H2O2 except HC. Next, they received Linum Usitatissimum (Lu) supplementation and Low-Intensity Interval Training (LIIT). Finally, 24h after the last treatment session, the level of 6-methylguanine (6MG) and ATP were measured via the ELISA technique in cardiovascular tissue.
Results: The findings determined that Lu supplementation and Ae significantly diminish the 6-methyl guanine level in endothelial (F=111.3, p=0.0008, ƞ=0.9823) and heart cells (F=147.9, p=0.0005, ƞ=0.9867). Also, the ATP level was increased significantly in endothelial (F=342.6, p=0.0003, ƞ=0.9942) and heart cells (F=135.1, p=0.0013, ƞ=0.9854). However, no considerable changes were found for both factors in groups who received Ae or Lu singularly.
Conclusion: The study showed that concurrent administration of Lu and Ae could exert dynamic cardioprotective properties through their antioxidant effects.

Effect of high-intensity interval training and moderate-intensity continuous training with quercetin supplementation on the mitochondrial gene expression in the diabetic heart
Mojdeh Khajehlandi, Lotfali Bolboli,
Volume 12, Issue 2 (10-2024)
Abstract
Background: Mitochondrial function is an integral part of glucose-stimulated insulin secretion in pancreatic β-cells and is a hallmark feature of cardiovascular disease. It may contribute to the pathophysiology of diabetic cardiomyopathy and atherosclerosis. This study aimed to investigate the effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), combined with quercetin supplementation (eight weeks), on mitochondrial gene expression in the diabetic heart.
Methods: In this study, 35 adult male rats were equally divided into seven groups (n=5): healthy sedentary, diabetic sedentary, diabetic quercetin sedentary, diabetic HIIT (DHIIT), diabetic MICT (DMICT), DHIIT with quercetin, and DMICT with quercetin. The rats were fed a high-fat diet for eight weeks and subsequently treated with a single low dose of streptozotocin to create a model of type 2 diabetes mellitus (T2DM). Eight weeks (five times a week) of HIIT and MICT, with and without quercetin, were conducted for the training groups, and quercetin was injected over eight weeks at a dose of 15 mg/kg.
Results: Eight weeks of quercetin supplementation, HIIT, and MICT, with and without quercetin, significantly decreased blood glucose levels (P=0.001). Eight weeks of HIIT and MICT training increased nuclear respiratory factor-2 (NRF2) (P=0.001) and adipose triglyceride lipase (ATGL) (P=0.001) expression and decreased perilipin 2 (PLIN2) gene expression (P=0.001).
Conclusion: The training groups alone improved the gene expression of NRF2, ATGL, and PLIN2. Both training protocols, combined with quercetin, controlled blood glucose levels and improved antioxidant capacity. Thus, the reduction in blood glucose through quercetin supplementation appears to be a promising approach for managing T2DM.
 
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