Jorjani Biomedicine Journal

Background and objective: The effect of aerobic exercise (AE) on cardiovascular (CVD) related risk factors are still debatable. Therefore this randomized controlled clinical trial (RCT) was performed with unique and specific AE protocol to investigate the effect of eight-week AE only on female subjects with type 2 diabetes.
Material And Method: A controlled RCT was performed on 30 women with type 2 diabetes aged 30 - 50. They were randomly divided into two groups, intervention and control by block randomization method. The intervention group received an incremental AE for eight weeks, three sessions per week, max heart rate (55-75%) and rating of perceived exertion (RPE) 12-13 for 150 minutes per week. Blood samples were taken before and after each intervention for both groups to be evaluated for fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile [triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C)].
Result: Eight-week AE intervention led to a significant decrease in HbA1c, FBS levels (p = 0.025, p=0.003) in experimental group compared to control however no significant differences was observed in terms of lipid profile (total cholesterol (TC), triglyceride (TG), LDL-C and HDL-C) between control and experimental group (p> 0.05). The results of paired t-test showed that FBS, TC and HbA1c levels were significantly reduced within experimental group after intervention compared to pre-test (p = 0.038, p = 0.05, p = 0.002, respectively). There was no significant difference between TG, LDL-C, and HDL-C levels within experimental group between pre and post-test (p>0.05).
Conclusion: It can be concluded that AE has been effectively reduce FBS, HbA1c and TC in women type 2 diabetes.

Background and Objective: Alpha-thalassemia (α-thal) appears to be the most common monogenic disorder worldwide. The diagnosis of α-thalassemia depends on the detection of Hemoglobin Bart (Hb Bart's) in newborns, which indicates one or more defective or absent α-globin genes. In addition, in patients with Hemoglobin H (Hb H), the Hb H range usually varies between 7-10 g / dL. Therefore, tracking Hb Bart's and Hb H can be useful in diagnosing thalassemia α. This study was performed to evaluate Hb Bart's and Hb H in infants with α thalassemia in Ardabil province, northwestern Iran.
Material and Methods: In this cross-sectional descriptive study, 33 infants with alpha thalassemia mutation, including infants born in Ardabil province, Iran in the years 2020 to 2019. Hemoglobin analysis was performed by capillary electrophoresis system.
Results: Hb H and Hb Bart's were detected in only two cases (6%) and three cases (9%). In this study, only 5 patients (15.15) were observable by detection of Hb Bart's and Hb H levels by electrophoresis. In cases of Hb Bart disease, -α3.7 was the most common genotype. Therefore, most infants with alpha thalassemia were lost when electrophoresis alone was used.
Conclusion: This study showed that molecular analysis of Hb Bart's newborns is necessary to confirm α-thalassemia. Capillary electrophoresis is a way to prevent the diagnosis of rare Hb H and Bart's disease.