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Showing 3 results for Taghian
The Effect of Aerobic Training with Royal Jelly Consumption on Health Related Anthropometric Markers in an Experimental Autoimmune Encephalomyelitis Model
Abdolhamid Mosalla Nezhad, Farzaneh Taghian, Khosro Jalali Dehkordi, Seyed Ali Hosseini,
Volume 9, Issue 4 (12-2021)
Abstract
Background and Objective: Interactive effects of Aerobic Training (AT) and Royal Jelly (RJ) consumption is still not well understood in Multiple Sclerosis (MS). Therefore, the aim of this study was determine the effect of aerobic training with royal jelly consumption on health related anthropometric markers in an Experimental Autoimmune Encephalomyelitis (EAE) model.
Material and Methods: 49 EAE induced by complete Freund’s Adjuvant, model female Sprague-Dawley rats were assigned to 7 groups: (1) EAE, (2) sham (Sh), (3) RJ50 mg/kg, (4) RJ100, (5) AT, (6) AT+RJ50, (7) AT+RJ100. Also, 7 healthy rats were put in the healthy control group (HC). AT was performed for five weeks, four sessions per week at a speed of 11-15 m/min for 30 minutes and RJ was IP injection for 50 and 100 mg/kg/day.
Results: In the AT, AT+RJ50, AT+RJ100 and RJ100 groups, weight, visceral fat weight and aerobic power were higher than the EAE group (P≥0.05); in the RJ50 group, weight and in the RJ100 and AT+RJ100 groups, BMI was lower than the EAE group (P≥0.05). AT+RJ100 reduced food intake compared to the EAE group (P≥0.05); also, aerobic power in the AT, AT+RJ50 and AT+RJ100 groups was higher than the RJ50 and RJ100 groups (P≥0.05).
Conclusion: Generally AT and RJ alone improved anthropometric markers in EAE model; also interaction of AT and RJ was dependent of dosage of RJ so that the effect of 100 mg/kg dosage was higher than 50 mg/kg.

Endurance Training and Consumption of Hydroalcoholic Zingiber Officinale Extract Regulated PPARγ, PGC1-ɑ/TNF-ɑ Expression Level in Myocardial Infarction Rats
Monireh Omomi, Farzaneh Taghian, Gholamreza Sharifi,
Volume 10, Issue 2 (5-2022)
Abstract
Background and objectives: Zingiber officinale extract can control cardiovascular risk factors. Moreover, endurance training may effectively rehabilitate myocardial infarction by strengthening the myocardial muscle tissue. In-silico analysis identified essential genes involved in the heart damage process based on data from the DisGeNET database. Hence, we estimated the affinity of chemical and bioactive molecules for PPARγ. Therefore, this study aimed to investigate the effect of endurance exercise alone or combined with Zingiber officinale extract on Myocardial infarction rats.
Material and Methods: Twenty-five male rats were randomly divided into five groups, including (1) group of myocardial infarctions (MI) induced by subcutaneous injection of isoproterenol, (2) myocardial infarction+exercise (MI+EX), (3) myocardial infarction+Zingiber Officinale extraction administered orally (MI+GE), (4) myocardial infarction+exercise+Zingiber Officinale extract (MI+EX+GE), and (5) Control group. The qPCR-Real Time technique was used to measure the expression of PGC1-ɑ, PPARγ, and TNF-ɑ genes. We evaluated the concentration of Troponin-1 as a vital myocardial ischemia marker.
Results: In bioinformatics analysis, we found that the PPARγ, PGC1-ɑ, and TNF-ɑ pathways were critical in heart injury. Also, the effects of Zingiber officinale on heart tissue were detected through PPARγ by drug design. Endurance training combined with Zingiber officinale consumption reduced the expression of TNF-ɑ, Troponin-1 and increased the PGC1-ɑ, PPARγ genes. Furthermore, consumption of Zingiber officinale extraction improved the levels of PGC1-ɑ, PPARγ, TNF-ɑ, and Troponin-1.
Conclusion: Our data indicated that six weeks of endurance training and consumption of Zingiber officinale extract could reduce the relative expression of the TNF-ɑ and significantly increase the level of PGC1-ɑ, PPARγ.


Exploring the effects of aerobic exercise combined with chitosan nanoparticle-encapsulated ginger on miRNA-214 and SERCA2a in isoproterenol-induced myocardial infarction in rats
Vahid Fallahzadeh, Farzaneh Taghian, Khosro Jalali Dehkordi,
Volume 11, Issue 3 (12-2023)
Abstract
Background: Aerobic exercise and ginger after myocardial infarction (MI) modify calcium handling. Ginger has cardioprotective effects on cardiovascular disease. This study assessed the effects of aerobic exercise combined with ginger extract (GE) loaded into chitosan nanoparticles (CNPs) on miRNA-214, Serca2a, and Anp genes and cardiac fibrosis in myocardial infarction (MI) rat models.
Methods: Twenty-five male rats divided into 5 groups were subjected to ginger treatment and exercise. Aerobic exercises (AE) were performed on a rodent treadmill 5 days per week for 6 weeks. The GE-CNPs (500 mg/kg) were orally administered to the rats for 6 weeks. The expressions of miRNA-214, Serca2a, and Anp genes were assessed by real-time polymerase chain reaction (PCR). The histopathological assessments were performed using hematoxylin and eosin (H&E) and Masson's trichrome staining. The serum activities of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) were also measured by ELISA.
Results: The MI model and CNP groups had the highest rate of collagen deposition (P <0.05). The serum activities of both CK-MB and LDH were significantly elevated in the Isop group compared to the control (P<0.05), while following aerobic exercise and ginger treatment, their activity was significantly dropped in the Isop + AE + GE-CNPs group. The expression of miRNA-214 showed a significant increase in GE-CNPs (P <0.01) and GE-CNPs + AE (P <0.001) groups. Serca2a and Anp genes showed significant changes in the GE-CNPs + AE group (P<0.05).
Conclusion: Our findings revealed that aerobic exercise, along with ginger treatment, improved cardiac fibrosis, modulating the expression levels of miRNA-214, Serca2a, and Anp genes and serum levels of MI biomarkers.
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