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Efficacy of Cognitive-behavioral Group Therapy for Depression in Patients with Brain Tumors and Increased Hope
Hamidreza Nikyar, Zohreh Reisi, Habibeh Farokhi,
Volume 1, Issue 2 (10-2013)
Abstract

Aims:

The purpose of this study was evaluating the efficacy of cognitive be Behavioral group therapy on

depression and hipness brain Tumor .

Method:

ineachgroup . the experimental group received 4weekly cognitive behavioral therapy session the question nears

depression beak and hope eshaneder were usadas the pre test ,post test and follow-up. The follow-up study was

conducted two months .

options were selected and assigned to two experimental and control group with brain tumor patients

Results:

after the last in tevrnationsessiony the result of covariance analysis showed that the mean scores

of depression in post test was significantly lower than control group (P<0.001) and follow-up (P<0.001) the

e result also showed that the scores of hope higher than con tral group in past test (P<0.001) and follow-up

(P<0.001) it is concluded that cognitive behavioral therapy, could happy life brain tumor.

Conclusion:

pharmacological interventions should be used in patients with brain tumors.

The results suggest that Cognitive Behavior Treatment boat as a valuable addition to surgical and
Sensitivity profile of carbapenem-resistant uropathogenic bacterial isolates to Cefiderocol
Fatemeh Omidi , Leila Fozouni , Arash Nikyar , Mehr Ali Mahmood Janlou,
Volume 12, Issue 2 (10-2024)
Abstract
Background: Cefiderocol is a siderophore cephalosporin with unique cell-penetrating abilities against multidrug-resistant (MDR) Gram-negative bacteria, especially carbapenem-resistant strains. This study aimed to evaluate the prevalence and susceptibility profiles of Cefiderocol on carbapenem-resistant uropathogenic Escherichia coli and Klebsiella pneumoniae isolates among hospitalized patients.
Methods: One hundred twenty-nine patients more than 72 h admitted to hospitals participated from Feb. 2021 to Dec. 2022. Urine samples were examined to identify uropathogenic K. pneumoniae and E. coli isolates based on microscopic morphology, cultural and biochemical methods. The carbapenemase production in the isolates was evaluated using modified Hodge tests and PCR. The MIC of Cefiderocol against carbapenemase-producing isolates was evaluated according to CLSI-2021 guidelines.
Results: According to phenotypic and genotypic tests, among forty-two E. coli isolates (71.19%) were carbapenemase positive, 38 isolates had the blaOXA gene (90.47%), and among twenty-four K. pneumoniae isolates 96% contained the blaKPC gene. In MIC determination 55.24% of carbapenem-resistant E. coli isolates were inhibited with ≤0.5 μg/ml of Cefiderocol, while only two strains (8.33%) of K. pneumoniae isolates showed resistance to the Cefiderocol (MIC90=2 μg/ml).
Conclusion: The present results demonstrate that the emergence of carbapenem-resistant uropathogenic bacteria poses a critical health threat to society. Based on the results, Cefiderocol demonstrated efficacy against carbapenem-resistant clinical isolates at low concentrations.
 

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