Fatemeh Abbasi , Nazanin Mortazavi , Nasser Behnampour , Masoud Mohammadi, Saeed Mohammadi,
Volume 0, Issue 0 (4-2024)
Abstract
Background: Oral cancer is the sixth most common cancer in the world and the third most common cancer in developing countries. Early detection of oral cancer can reduce mortality in several ways. The aim of the present study was to combine the quantitative results of various studies concerning serum and salivary microRNAs for early diagnosis of head and neck squamous cell carcinoma (HNSCC).
Methods: This systematic review and meta-analysis was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guideline. We searched all the relevant English studies in international databases of PubMed/Medline, Scopus, Web of Science, Cochrane, ProQuest, Embase, and Wiley until February 2022. A random-effects model was used to estimate the pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) for each study. A total of 672 articles were found. After screening, 93 articles were approved for systematic review. Finally, 5 completely relevant articles were examined in the meta-analysis.
Results: Considering all studies regarding miRNAs, the combined results indicated that AUC = 0.73, with a sensitivity of 71.68% and a specificity of 69.95%, could be used for HNSCC diagnosis. Due to the moderate sensitivity and specificity of miRNAs, they may be able to confirm or exclude suspected cases of this disease, enhancing their utility as clinical diagnostic indicators.
Conclusion: The available data provide evidence that miRNAs, especially MiR-31 expression in the saliva, serum, or plasma, can be used as a diagnostic biomarker for HNSCC patients. However, controlled clinical trials with large sample sizes are needed to validate different miRNAs.
Sara Sohrabvandi, Seyed Amir Mohgammad Mortazavian, Hamed Jahani, Mohammad Javad Eivani, Ameneh Nematollahhi, Rozita Komeili,
Volume 3, Issue 1 (5-2015)
Abstract
Background and objectives: Fortification of beverages with new functional ingredients such as prebiotics is one of the recent progresses in the field of juice production. Therefore, the objective of the present study was to evaluate the effects of adding some prebiotics such as Inulin and Tagatose on physicochemical and sensory properties of orange juice.
Methods: The prebiotic compounds (Inulin and Tagatose) along with sucrose were added to orange juice in specific proportions and then pasteurized at 90°C. Orange juice treated samples were kept at 4°C (refrigerator temperature) and 25°C (room temperature) for 3 months. Physicochemical (Brix, acidity, sucrose content and pH) and sensory properties of treated samples were evaluated within time intervals of one month.
Results: The results showed that storage temperature had no significant effect on pH, Brix and acidity of all treatments (P>0.05). On the other hand, total sugar content of all treatments had decreased significantly during storage (P<0.05), as the greatest decrease was observed in Inulin-3/Sucrose-3 treatment keeping at room temperature with 33.7%. It was reported that no change in the transparency treatments was observed (P>0.05). Storage of treatments at room temperature had decreased the acceptance of flavors significantly (P<0.05).
Conclusion: The result of this study showed that Inulin in combination with sucrose and Tagatose could be used to produce salutary juice with desirable sensory properties.
