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Showing 2 results for Mansouri

Borhan Mansouri, Namamali Azadi, Yazdan Habibi,
Volume 3, Issue 2 (10-2015)
Abstract

Background and Objective: The industrial development along with the rising in human population has led to releasing considerable hazardous materials such as heavy metals into the environment. Environmental pollution by heavy metals can in turn threaten the human health. Therefore, the aim of this study was to assess the concentration levels of some heavy metals including; Cd, Pb, Cr and Cu, as well as to estimate the physico-chemical parameters of drinking water distribution network of Sanandaj city in 2014.

Methods: In order to accomplish the present descriptive study, 18 samples were collected from the water distribution network of Sanandaj during 2014. The level of heavy metals were assayed by using a graphite furnace atomic absorption (Phoenix 986). The standard approaches mentioned in the standard method book were used to measure the fluoride, nitrate and hardness of water. The Pearson Correlation test was used to estimate the association between parameters.

Results: The mean concentrations of Cd, Pb, Cr and Cu were found to be 0.0004, 0.011, 0.03, 0.3 mg/L respectively. Moreover, the mean levels of fluoride, nitrate, and total hardness were 0.11, 6.57, and 166 mg/L respectively. The level of Hazard Quotient in this study was lower than 1 (HQ < 1).

Conclusion: The concentration of all heavy metals in this study were lower than the national and international thresholds of drinking water. It is concluded that Sanandaj drinking water is safe to drink concerning health issues.  


Samaneh Heidarzadeh, Seyedehsamira Ashrafmansouri,
Volume 11, Issue 4 (12-2023)
Abstract

Background: Gastric cancer is the fifth most common neoplasm and the fourth leading cause of mortality worldwide. Incidence rates vary widely and depend on risk factors, epidemiological factors, and carcinogenesis patterns. Understanding the molecular mechanisms underlying cancer progression and metastasis is crucial for developing effective therapeutic strategies. Previous studies have reported that fascin overexpression, an actin-binding protein, promotes cell motility and invasion in cancers by bundling actin filaments. Therefore, inhibiting this protein can be a major step in treatment.
Methods: In this prospective study, the protein structure of fascin was obtained from the Protein Data Bank (PDB). Using the HyperChem 7.0 software, the chemical structure of cytochalasin H as a small molecule inhibitor was designed. Rigid docking studies between cytochalasin H and fascin protein were performed using the AutoDock Vina 1.1.2 software, and the obtained results were analyzed using LigPlot+ v.1.4.5, Discovery Studio 4.5, and PyMOL v.1.9 software.
Results: According to the analyses and the obtained results, cytochalasin H and fascin protein have an effective interaction with an optimal energy level.
Conclusion: These findings suggest that cytochalasin H may be developed into a potential chemotherapeutic drug for the treatment of gastric cancer by inhibiting fascin. Nevertheless, further in vitro and in vivo experiments are necessary to elucidate the exact mechanism.


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