Showing 8 results for Khosravi
Ali Maleka, Dr Nasser Behnampour, Dr Seyed Kamal Mirkarimi, Sadegh Khosravi, Asghar Khosravi,
Volume 5, Issue 2 (10-2017)
Abstract
Background & Objective: Animal bites are a major threat to human health, while the subsequent infections such as Rabies could be lethal. The aim of this study was to determine the epidemiologic status of animal bite and the effect of wasting stray dogs on the incidence of animal bites in Galikesh County since 2009 until 2013.
Methods: The present study was a cross-sectional study with descriptive-analytical approach. A total of 1712 animal-bitten cases who were residing in Galikesh during the years of 2009-2013 were enrolled by census method. Data were collected from the recorded documents of animal-bitten individuals and analyzed by SPSS.
Results: Of all cases, 1203 (70.3%) individuals were male and 509 (29.7%) were female. Regarding the age, cases were ranged between 1 to 89 years with a mean and standard deviation of 26.88 ± 18.39 years. The majority of bite cases (92.3%) were related to dogs. Moreover, 71.4% of bites were on legs. There was a significant relationship between sex and the place of residence as well as between the place of the event (biting) and delay to the first vaccination (P <0.05). Wasting the stray dogs has no effect on reducing the incidence of bites (P <0.05).
Conclusion: The current plan of wasting the stray dogs has no effect on reducing the incidence of bites in Galikesh. Therefore, it is recommended to carry out controlling programs, education and community awareness in this field.
Dr Omid Mozafari, Dr Ayyoob Khosravi,
Volume 6, Issue 3 (9-2018)
Abstract
Dear Editor,
I would like to point out some issues regarding the article entitled "Sayyed Ismael Jorjani, The famous Iranian physician and philosopher" by Seyyed Alireza Golshani that has been published in the journal of Jorjani Biomedicine Journal Volume 2, Issue 2 (Autumn 2014 & winter 2015 2014) and is about the great 11th-12th century physician, Ismael Jorjani.
Ayyoob Khosravi, Fariba Kokabi, Ramezan Behzadi, Jahanbakhsh Asadi,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cells helps us to study their function and behavior. In the current study we separate cancer stem-like cells using sphere formation assay then investigate their tumorigenicity in xenograft tumor model.
Methods: YM1 cancer cells were cultured in serum-free media (SFM) in low adherent culture dishes for enrichment of cancer stem cells. The resulting spheres containing cancer stem-like cells were dissociated into single cells and were injected into the dorsal flank of B6 nude mice.
Results: A few days after injection, subcutaneous tumors formed. The growth curves of the resulting tumors were plotted using their weekly recorded lengths. The tumors' volume and weight were measured. The size of resulting tumors was appropriate to the number of cells injected. Pathological analysis confirmed esophageal origin of the resulting tumors.
Conclusion: Using laboratory mice models is a practical modeling system that provides us investigation of human tumors pathogenesis in vivo.
Farideh Kaikhosravi, Farhad Daryanoosh, Maryam Koushkie Jahromi, Javad Nemati,
Volume 8, Issue 1 (3-2020)
Abstract
Background and objective: Proper exercise and nutrition can help prevent bone disorders in old age, therefore present study aimed to investigate the effects of high intensity interval training (HIIT) with genistein (Ge) on biomechanical properties of femur bone in elderly female rats.
Material and Methods: In this experimental study, 40 elderly female rats with mean age of 18- 24 months and mean weight of 220.15±15.28 g were divided into five groups of eight rats including: 1) control (C), 2) sham (Sh), 3) HIIT, 4) HIIT + Ge, and 5) Ge. During eight weeks groups 3 and 4 performed HIIT for three sessions per week with an intensity of 90 to 95% of maximum oxygen consumption (VO2max) in high intensity intervals and 40 to 45% VO2max in low intensity intervals and groups 4 and 5 received 60 mg/kg/day Ge peritoneally. Maximum bending strength (Fmax) measured with three- point bending test and serum levels of calcium (Ca) and phosphorus were measured by o-Cresolphthalein and molybdate methods, respectively. Shapiro- Wilk, one way ANOVA with Tukey’s post- hoc tests were used for analysis of data (P≤0.05).
Results: HIIT (P=0.02), Ge (P=0.001) and HIIT+Ge (P=0.001) significantly increased Fmax also Ge (P=0.04) and HIIT+Ge (P=0.03) had more favorable effect on increasing Fmax compare to HIIT nevertheless HIIT, Ge and HIIT+Ge had not significant effect on Ca and phosphorus (P≥0.05).
Conclusion: Although HIIT and Ge alone can enhance Fmax in femur of elderly female rats, nevertheless HIIT+Ge has more favorable effect on increase of Fmax compare to HIIT.
Masoud Esmaeili, Negin Khosravi, Ali Habibi Kia,
Volume 8, Issue 2 (7-2020)
Abstract
Background: Supernumerary teeth are known as the teeth in excess of the normal dentition. Multiple supernumerary teeth are usually observed as having syndromes. Conversely, multiple supernumerary teeth without any associated systemic conditions or syndromes are not common.
Case presentation: This article documents an unusual case report, a male patient with non-syndromic 10 supernumerary teeth in both jaws, an incidental finding during routine radiographic examination.
Conclusion: CBCT is the best diagnostic imaging method currently available for determining the relationships of teeth and the surrounding structures in cases with multiple impacted teeth or severe overlapping of impacted teeth.
Ayyoob Khosravi,
Volume 8, Issue 2 (7-2020)
Abstract
Stem cells isolated from human exfoliated deciduous teeth (SHEDs) are multipotent mesenchymal stem cells that are isolated from dental pulp tissues. These cells have a high proliferative capacity, multipotential ability, immunomodulatory function, and minimal risk of oncogenesis. Recent studies have shown that SHEDs are a feasible cell source for cell therapy and regenerative medicine.
Vahideh Faghani Zadeh, Nazila Arbab Soleimani, Ayyoob Khosravi, Mohammad Mahdi Forghanifard,
Volume 10, Issue 4 (12-2022)
Abstract
Background and Objectives: Oral cancer relates to oral and intestinal microbiota composition. Lactobacillus species are considered probiotic bacteria due to their ability to modulate human immune responses and therapeutic effects. This study aimed to investigate the effects of Lactobacillus plantarum (L. plantarum) on TLR4 gene expression and its downstream pathways in a mouse model of oral cancer.
Material and Methods: This experimental study was conducted in the Stem Cell Research Center, Faculty of Modern Technologies, Golestan University of Medical Sciences, Gorgan, Iran, in 2021. L. plantarum strain ATCC 8014 was used in this study. Twenty-eight male Wistar rats were divided into four groups (n = 7). 4-Nitroquinoline 1-oxide (4NQO) was used to establish oral cancer in rats. A pathological examination was adopted to confirm cancer establishment. Rats were treated with probiotic L. plantarum before and after cancer development. After extracting RNA from blood and synthesizing cDNA, the ability of lactobacilli to modulate the expression of TLR4 genes was investigated by Real-Time PCR Methods (RT-PCR).
Results: In the present study, it was observed that after causing cancer and treating the animal with L. plantarum, the expression of the TLR4 gene decreased significantly (P-value < 0.05), which might, in turn, affect the downstream pathways, which included the decrease in the expression of BCL-2 and NF-ĸB genes. Accordingly, the expression of the NF-ĸB gene was significantly reduced in rats received L. plantarumgavaged for two weeks after cancer induction.
Conclusion: According to the obtained results, probiotic L. plantarum significantly affects the gene expression of NF-ĸB and TLR4 in cancerous rats. It was also shown that L. plantarum was more efficient in reducing TLR-4 and NF-ĸB genes expression when it was gavaged for 14 days after tumor induction.
Ailar Jamali , Mojtaba Zare Ebrahimabad, Sareh Zhand, Ayyoob Khosravi,
Volume 11, Issue 2 (10-2023)
Abstract
Background: Genetic polymorphisms are predictors of the immune response and susceptibility to certain infectious diseases, including pulmonary tuberculosis (TB). We evaluated the association of monocyte chemoattractant protein-1 (MCP1) (-2581 A/G) and interferon-gamma (IFNγ) (+874 T/A) polymorphisms with susceptibility to pulmonary TB in an Iranian population.
Methods: A total of 124 patients with pulmonary tuberculosis and 244 healthy subjects (121 related normal controls and 123 unrelated subjects) were included. The MCP1 polymorphic region (-2518 A/G) was genotyped by PCR-RFLP, while ARMS-PCR was used to amplify and detect IFNγ (+874 T/A). SNPStats and SPSS v. 20 were used for the statistical analysis of the data.
Results: The comparison of MCP1 (-2518 A/G) alleles and genotypes in TB patients and healthy subjects showed no significant association in all the constructed heredity models. No association was observed between TB patients and normal subjects in all the constructed inheritance models for IFNγ (+874 T/A) alleles and genotypes.
Conclusion: Due to the lack of association between MCP1 (-2518 A/G) and IFNγ (874 T/A) polymorphisms and susceptibility to PT in our study and the conflicting results of some previous studies, further clinical and molecular research is needed to clarify the role of the studied polymorphisms in the pathogenesis of tuberculosis.
