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Showing 3 results for Jalilvand
Study the Molecular Association between a Deletion Mutation in CHEK2 gene (5395 bp) and Breast Cancer
Manijeh Jalilvand, Reza Najafipoor, Mohammad Shekari, Mana Oloomi, Safar Ali Alizadeh, Abdolazim Nejatizadeh,
Volume 3, Issue 1 (5-2015)
Abstract

Background & Objectives: Breast cancer is the most common cancer among women and the second most common cause of cancer death. Genetic factors play an important role in the development of breast cancer. Among these genetic factors, CHEk2 (checkpoint kinase 2) gene, as a tumor suppressor gene, plays a critical role in DNA repair. Germline mutations in CEHK2 result in the loss of this feature. One of the mutations in CHEK2 gene is a 5395 bp deletion mutation which has been associated with the increasing risk of Breast Cancer in some populations in the world.  In the present study, we investigated the association between a 5395 bp deletion mutation in CHEK2 gene and the risk of Breast Cancer in the women of an Iranian population.

Methods: Pathologic information of 38 cases under the age of 45 and 62 cases over the age of 45 referring to surgery ward of Milad Hospital in Tehran were extracted. 100 healthy controls were included in the study as well. After obtaining informed consent, 5 mL whole blood was taken DNA was successfully isolated. Multiplex PCR was used to investigate the association between a 5395bp deletion mutation in CHEK2 gene and increasing risk of Breast Cancer among patients.

Results: The 5395bp deletion mutation in CHEK2 gene was not found in any of the participating groups of patients or heathy controls.

Conclusion: The present study revealed that there is no significant relation between increasing the risk of Breast Cancer and bearing large deletion mutation in exon 9 and exon 10 of CHECK2 gene.


The effectiveness of physical activity with motor-cognitive approach on executive function in children with Attention Deficit/Hyperactivity Disorder
Mohammad Jalilvand, Hossein Samadi,
Volume 8, Issue 2 (7-2020)
Abstract
Background and objective: Psychological studies with behavioral therapy and cognitive therapy approaches seek to discover ways to treat attention deficit / hyperactivity disorder (ADHD). The aim of the present study was to investigate the effectiveness of 12 weeks of physical activity with motor-cognitive approach on response inhibition and sustained attention in children with the symptoms of ADHD.
Material And MethodS: The present study was a quasi-experimental with a pretest-posttest design. The statistical population of the study consisted of all children aged 9 to 11 years with a history of 1 to 2 years of ADHD symptoms in Kermanshah. 30 children with ADHD voluntarily participated in the study and divided randomly in the experimental and control groups. Participants in the experimental group performed motor-cognitive training with moderate-intensity for 12 weeks (2 sessions in week) and 60 minute per session. The present research instrument was the Wechsler’s intelligence scale, the SNAP questionnaire, the stroop test and the continuous performance test. To analyze the data, multivariate and univariate analysis of covariance were used.
Results: The results showed a significant improvement in response inhibition (F1,28=63.1, sig=0.001) and sustained attention (F1,28=32.9, sig=0.001) scores in children with ADHD in the experimental group following 12 weeks of training (p≥0.001).
Conclusion: 12 weeks of physical activity with motor-cognitive approach had a positive effect on response inhibition and sustained attention in children with ADHD. Therefore, it is recommended that children with ADHD participate in physical activities with motor-cognitive approach to improve response inhibition and sustained attention.

Motor skill enhancement in children with ADHD: The impact of a targeted sport-based intervention
Mohammad Jalilvand,
Volume 13, Issue 3 (7-2025)
Abstract
Background: Children with attention-deficit/hyperactivity disorder (ADHD) frequently demonstrate significant impairments in fundamental motor skills (FMS), including locomotor and object control abilities. This study investigated the efficacy of an 8-week table tennis training program as a targeted intervention to improve FMS in this population.
Methods: In a quasi-experimental study, 30 male children with ADHD (aged 9 - 12 years) were assigned to either an experimental group (n = 15) or a control group (n = 15). The experimental group participated in a structured, 8-week table tennis training program, while the control group continued with their routine activities. The Test of Gross Motor Development-3 (TGMD-3) was administered to assess locomotor and object control skills before and after the intervention. Data were analyzed using paired t-tests and Analysis of Covariance (ANCOVA) in SPSS-19.
Results: Following the intervention, the experimental group exhibited significant improvements in both locomotor (from 27.93 ± 1.90 to 31.33 ± 2.29, P-value < 0.001, η2 = 0.80) and object control skills (from 25.40 ± 1.91 to 29.93 ± 2.49, P-value < 0.001, η2 = 0.36). The control group showed no significant changes. ANCOVA results, controlling for baseline scores, confirmed a substantial between-group difference in the total motor score (F (1, 27) = 86.06, P-value < 0.001, η2 = 0.76).
Conclusion: An 8-week table tennis training program is an effective and feasible intervention for enhancing fundamental motor skills in children with ADHD. These findings support the integration of structured racket sports into physical activity programs to address motor proficiency deficits in this clinical population.

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