Jorjani Biomedicine Journal

Background and Objective: The application of exercise training and herbal supplements is believed to be a typical approach in treating chronic diseases and metabolic disorders. Accordingly, given the healing effects of swimming training and cannabidiol (CBD) oil consumption, the aim of the current study was to reveal if eight weeks of swimming training and CBD oil consumption downregulates the expression of MAPK, PPARα genes in the heart tissue of myocardial infarction rats.
Material and Methods: In the present experimental study, 20 myocardial infarction rats were divided into four groups of five animals, including: 1) control, 2 swimming training, 3) CBD, 4) CBD + swimming training, and 5) healthy control. For eight weeks, groups 3 and 4 consumed 50 mg/kg of CBD daily by gavage, and groups 2 and 4 performed swimming training five days a week. Induction of myocardial ischemia was performed by subcutaneous injection of isoproterenol (50 mg/kg i.p.), in myocardial infarction rats. Bax and Bcl2 cardiomyocytes were measured by PCR-RT. For data analysis, one-way analysis variance test was used to compare inter-group differences at P<0.05.
Results: Swimming training, CBD consumption and swimming training with CBD consumption had a significant effect on reducing MAPK gene expression in cardiac tissue (P≤0.05). Also, swimming training with CBD consumption had a greater effect than swimming training and CBD consumption alone on reducing PPARα gene expression in cardiac tissue (P≤0.05).
Conclusion: It appears that application of swimming training with CBD oil consumption has more positive impacts on improving MAPK and PPARα gene expression levels in the heart tissue of rats with myocardial infarction than using each one alone. Besides, swimming training with CBD oil consumption plays a role in the rehabilitation process and improves key factors involved in cardiovascular health.

Background and Objective: Interactive effects of Aerobic Training (AT) and Royal Jelly (RJ) consumption is still not well understood in Multiple Sclerosis (MS). Therefore, the aim of this study was determine the effect of aerobic training with royal jelly consumption on health related anthropometric markers in an Experimental Autoimmune Encephalomyelitis (EAE) model.
Material and Methods: 49 EAE induced by complete Freund’s Adjuvant, model female Sprague-Dawley rats were assigned to 7 groups: (1) EAE, (2) sham (Sh), (3) RJ50 mg/kg, (4) RJ100, (5) AT, (6) AT+RJ50, (7) AT+RJ100. Also, 7 healthy rats were put in the healthy control group (HC). AT was performed for five weeks, four sessions per week at a speed of 11-15 m/min for 30 minutes and RJ was IP injection for 50 and 100 mg/kg/day.
Results: In the AT, AT+RJ50, AT+RJ100 and RJ100 groups, weight, visceral fat weight and aerobic power were higher than the EAE group (P≥0.05); in the RJ50 group, weight and in the RJ100 and AT+RJ100 groups, BMI was lower than the EAE group (P≥0.05). AT+RJ100 reduced food intake compared to the EAE group (P≥0.05); also, aerobic power in the AT, AT+RJ50 and AT+RJ100 groups was higher than the RJ50 and RJ100 groups (P≥0.05).
Conclusion: Generally AT and RJ alone improved anthropometric markers in EAE model; also interaction of AT and RJ was dependent of dosage of RJ so that the effect of 100 mg/kg dosage was higher than 50 mg/kg.

Background: Goalball is a distinctive athletic activity tailored for individuals who are blind or partially sighted. It is aimed at promoting physical activity and preventing sedentary behavior. This study explores the impact of high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on muscle damage and inflammation markers in goalball players over eight weeks.
Methods: In this semi-experimental study, 24 male goalball players were randomly assigned to one of three groups: a control group, a HIIT group, and a moderate-intensity interval training (MIIT) group. The HIIT regimen involved intermittent running for 30 seconds at 100-200% of HRR, followed by 30 seconds of active recovery at 50% HRR. The MIIT protocol consisted of 25 minutes of training at 40-50% HRR, progressing to 30-35 minutes at 60-65% HRR over the last four weeks. Data were analyzed using repeated measures ANOVA, with a significance threshold set at P-Value <0.05.
Results: The results displayed that HIIT and MIIT had a significant effect on the concentration of CK (P-Value < 0.001), LDH (P-Value < 0.001), and IL-6 (P-Value < 0.001). Also, compared to MIIT, HIIT caused a significant decrease in the concentration of CK (P-Value < 0.001), LDH (P-Value < 0.001), and IL-6 (P-Value < 0.001).
Conclusion: HIIT exerts a more pronounced effect on CK, LDH, and IL-6 concentrations than MIIT. These findings suggest that HIIT may be more effective in enhancing physiological markers in individuals with disabilities, promoting better health outcomes.
 

Background: Hypothyroidism is typically associated with a decreased basal metabolic rate, reduced energy expenditure, and weight gain. Exercise training and Dorema Aucheri (DA) have been identified as beneficial therapeutic strategies within complementary health approaches. Skeletal muscle metabolism and fiber type are regulated by innervation and soluble factors, such as thyroid hormones. However, the mechanisms between muscle function and hypothyroidism remain unclear.
Methods: Thirty mice were divided into five subgroups: the normal group; hypothyroid mice (HYPO, 8 mg/kg of propylthiouracil administered via intraperitoneal injection for 30 days); hypothyroid mice treated with DA (gavaged at 0.4 mg/kg for two months, five days per week); hypothyroid mice treated with exercise (75% VO2 max, 45 minutes per session, for two months, five days per week); and hypothyroid mice treated with both DA and exercise. The mRNA expression levels were detected via real-time qPCR.
Results: The data indicated that PPARγ, mTOR, and PI3K levels are reduced in hypothyroidism. DA and exercise enhanced PPARγ, mTOR, and PI3K levels in muscle tissue. Notably, DA and exercise significantly increased the expression levels of PPARγ, mTOR, and PI3K.
Conclusion: Exercise and DA, as alternative and complementary medicine, modified the PPARγ/mTOR/PI3K signaling pathways affected by hypothyroidism in mice.