Showing 15 results for Jafari
Mahsa Mahdizadeh, Zahra Arab-Bafrani, Seyyed Mehdi Jafari,
Volume 0, Issue 0 (10-2024)
Abstract
Background: Esophageal cancer is one of the most common cancers worldwide. Because this disease is usually diagnosed in advanced stages, its treatment is challenging and the survival rate of patients is relatively low. One of the parts that is disturbed in the tumor tissue of esophageal cancer is the tight connections between cells. Claudin-4 (CLDN-4) is one of the tight junction regulatory proteins whose changes are involved in cancer formation. In this systematic review, we examine the changes in CLDN-4 and the factors that affect its level in samples and cell lines related to esophageal cancer.
Methods: Scopus, PubMed, and Web of Science databases were searched for articles that examined CLDN-4 gene and protein expression in patients with esophageal cancer or cell lines related to esophageal cancer. A number of 202 manuscripts were obtained in the beginning, and after screening and applying the inclusion and exclusion criteria, six studies remained.
Results: Six studies, including 596 patients and seven cell lines related to esophageal tissues, were included in this systematic review. The studies were related to Japan, South Korea, China, and Finland. In these studies, the level of CLDN-4 in cancer samples related to esophageal cancer and their location in esophageal tissue cells have been examined.
Conclusion: In summary, it can be concluded that the change in the level of CLDN-4 in the tumor tissues of esophageal cancer altered the tight junctions from the normal state in the normal esophageal tissues, leading to a change in normal barrier function. However, considering the conflicting results in the reports, more studies are needed to accurately interpret the role of CLDN-4 in esophageal cancer.
Maliheh Alhavaz, Leila Mahasti Jouybari, Nafiseh Hekmati Pour, Akram Sanagu, Ladan Fazli, Fozieh Bakhsha, Seyyedyaghub Jafari,
Volume 1, Issue 2 (10-2013)
Abstract
Background and objectives
theaters and are not in appropriate conditions and need further support. Therefore, this study was conducted
with an objective to explain medical ethics in the operating theater and the clinical experiences of the students
of anesthesiology.
: Clinical students should become familiar with medical ethics and its principles from the beginning, observing it in their relationships with patients, in particular, the patients who are in operating
Methods:
University of Medical Sciences were studied using a purposive sampling method. The inclusion criteria of
the students included passing at least one semester of clinical experience in the ope
In this qualitative study with a phenomenological approach, 50 students of anesthesiology at Golestanrating theater, and having
inclination for participation in the study. The data collection tool was semi-structured interviews. The data were
analyzed using the conventional content analysis method. The data were analyzed in a regular three-phase pro
that is, open coding, axial coding and selective coding.
cess,
Results:
main theme derived from this study was that the patient is in the trust of us.
The themes concluded from this study for explaining medical ethics in the operating theater included trustworthiness, having a chaste look, confidentiality, observing the patient’s privacy and their clothing. The
Conclusion:
The results showed that the students of anesthesiology consider the patient as a member of their own family, and attempt to take care of the patient, who is in sensitive conditions, in the best possible way.
Alireza Heydari, Mohammad Javad Kabir, Ashrafi Babazadeh Gashti, Nahid Jafari, Mansoureh Lotfi, Mohammad Aryaei, Mohammad Reza Honarvar, Mohammad Ali Pourabasi, Maryam Iri,
Volume 2, Issue 2 (10-2014)
Abstract
Background & Objective: Job satisfaction Increases individual efficiency and commitment to the organization, ensuring the physical and mental health, life satisfaction and accelerate the learning of new skills on the job. The aim of this study was to determine the status of health professionals› satisfaction in the Golestan province.
Method: In this cross- sectional study, 1,275 health workers of Health centers in the Golestan province in the year 1391 were participated using the census method. Data was collected using Herzberg job satisfaction questionnaire. The data were analyzed using SPSS software, ANOVA and t-Test at the significant level of 0.05.
Results: Job satisfaction in terms of staff maintenance and support and given the potential and experience of individuals in granting liability were at dissatisfied level, In terms of corporate communications, career development, salary and benefits, challenges and job management, at relatively dissatisfied and from the aspect of social acceptance level was at relatively satisfied. Job satisfaction was significantly associated with work experience (P=0.049), ethnicity (P=0.009) and city of service location (P=0.001).
Conclusion: Due to poor job satisfaction levels, effective actions should be taken to improve organizational communication, career development, salary and benefits, social acceptance, staff maintenance and support, management, Job challenges, and granting responsibilities based on the ability and experience of the individuals.
Abolfazl Jafari-Sales, Parisa Bolouri,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: Today, due to the increasing antibiotic resistance of bacteria, the use of medicinal plants as a suitable alternative to antibiotics has increased significantly; therefore, in this study, the antibacterial effects of methanolic extracts of Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Escherichia coli were evaluated.
Methods: In this laboratory research, after collecting plants and confirming its scientific name, extract of Glycyrrhiza glabra L. Root was prepared by Soxhlet extractor method at concentrations of 20 mg / ml to 400 mg / ml. Then the antimicrobial effects of this extract were investigated using Agar well diffusion and Dilution test methods.
Results: The results showed that the methanolic extracts of G.glabra L. in both Agar well diffusion and Dilution test methods had antibacterial effects on the tested bacteria. The highest effect was observed on S.aureus and the lowest effect was observed in P.aeruginosa.
Conclusion: According to the above results, it can be expected that the G.glabra L. extract can be used to treat bacterial infections and is a suitable alternative to commonly used chemical treatments for the treatment of infections.
Javad Sayyahi, Hayedeh Mobaiyen, Behboud Jafari, Abolfazl Jafari-Sales,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: As much as people become aware of the dangerous side effects of synthetic antibiotics, the demand for natural alternatives to these drugs increases. Natural ingredients, lower risk of complications and even have beneficial side effects. The aim of this study was to determine the antibacterial effect of herbs Reum ribes L and hyssop Hyssopus officinalis is on some pathogenic bacteria.
Methods: After collecting and confirming the scientific name, the methanolic extract of R. ribes L. and H. officinalis plants was prepared and the antimicrobial effects of the extracts by agar well diffusion and disk diffusion , as well as the determination of The minimum bactericidal concentration and the minimum inhibitory concentration (MIC / MBC) were dilution test on Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa.
Results: The highest growth inhibitory zone in S. aureus, B. cereus, P. aeruginosa, and E. coli at concentrations of 400 mg / ml, respectively, in the disc method of 13.21, 13.41, 11.2 and10.74 mm and the well method, respectively 13.64, 13.11, 10.67 mm, and 9.38 mm for the R. ribes L extract, and the disc method of 11.74, 10.2, 10.71, and 9.1 mm, and the well method of 12.41, 11.6, 10.2, and 9.9 respectively. 4.3 mm was observed for H. officinalis extract. The results of MBC / MIC showed that the extract of medicinal plants had the highest susceptibility to B. cereus bacteria and the least susceptibility to E. coli.
Conclusion: R. ribes L. and H. officinalis plants have significant inhibitory effects on the growth of pathogenic bacteria in vitro. Therefore, it can be expected that these extracts can be used for the treatment of bacterial infections and are a good alternative to the usual chemical treatments for the treatment of infections.
Samira Mahmoudi, Rozita Nasiri, Abolfazl Jafari Sales,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objectives: Microbial resistance to antibiotics is one of the most common problems in the health care system. Therefore, many efforts have been performed to find new compounds as antimicrobial compounds. This study carried out to investigate the in-vitro antibacterial effect of methanolic extract of peppermint on standard Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa strain.
Material and Methods: In this experimental laboratory study, after collecting and performing pharmacognosy evaluations, methanolic extract of the peppermint plant was prepared and its antimicrobial effects on several bacteria were determined at concentrations of 20 to 400 mg/ml using the agar well diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) methods. The test was repeated five times for each bacterium and the collected data were analyzed using SPSS software.
Results: It was revealed that the methanolic extract of peppermint had antimicrobial effects against standard Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The highest effect was observed in S. aureus and the least in P. aeruginosa. MIC and MBC of methanol extract on S. aureus, B. cereus, E. coli, and P. aeruginosa were 6.5-15.5, 15.5-25, 50-100, and 100-200 mg/ml, respectively.
Conclusion: The results of this study reveal that peppermint can be considered as an antibacterial medicinal herb and that if the concentration of the extract is higher, its antibacterial properties will also increase. Thus, it can be used as an alternative to the usual chemical drugs in the treatment of infections after evaluating their effects in vitro.
Faegheh Jafari Amoli, Seyed Ali Hosseini, Mohammad Ali Azarbayjani, Parvin Farzanegi Arkhazloo,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objectives: It has been reported that deep-fried oils (DFOs) used in the preparation of fast foods can affect the immune system. On the other hand, regular physical activity and proper nutrition, in addition to affecting physical function, have a tremendous impact on the immune system. The aim of the present study was to investigate the anti-inflammatory effects of aerobic training (T) and octopamine (O) consumption in the heart tissue of rats fed DFO.
Methods: In this experimental study, 25 male Wistar rats with mean age of 20 weeks old and weighing 300- 350 were purchased and divided into 5 groups of 5 rats, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O and 5) DFO+T+O. During four weeks, groups 2- 5 received DFO by gavage; groups 3- 5 ran on treadmill (with speed of 50% Vo2max in the first week which reached 65% Vo2max in the last week) five sessions per week and 20 minutes per session and groups 4-5 received 81 μmol/kg octopamine supplement peritoneally for 5 days per week. Nuclear factor kappa B (NF-κB) and tumor necrosis factor-alpha (TNF-α) gene expression were measured in heart tissue.
Results: DFO significantly increased NF-κB (P=0.005) and TNF-α (P=0.001) gene expression levels; T significantly on decreased NF-κB (P=0.01) and TNF-α (P=0.007) gene expression levels; O consumption significantly decreased NF-κB (P=0.001) and TNF-α (P=0.001) gene expression levels; however, the interactive effects of T and O consumption on NF-κB (P=0.57) and TNF-α (P=0.20) gene expression levels was not significant.
Conclusion: It seems that T and O consumption alone have anti-inflammatory effects on the heart tissue of rats fed DFO, however T and O do not have anti-inflammatory interactive effects.
Abolfazl Jafari-Sales, Homeira Khaneshpour, Mehrdad Pashazadeh, Rozita Nasiri,
Volume 8, Issue 1 (3-2020)
Abstract
On December 31, 2019, the Wuhan-China Health Commission reported a case of pneumonia in the city. The first symptoms began in mid-December 2019. Clinically isolated specimens identified the coronavirus as the cause of the disease. It was first shown as 2019-nCoV, and as the number of victims of the coronavirus crossed the border of thousands of people, the World Health Organization chose the official name COVID-19 for its illness. Although it appears to be of animal origin, it is rapidly transmitting from person to person around the world. The World Health Organization released a statement calling the outbreak of the new Corona virus a Public Health Emergency Situations that poses a threat to the whole world, not just China. In this study highlights how the virus is transmitted, the clinical signs, the laboratory characteristics, the pathogenicity of the virus, Vaccines, and the prevention and control of the spread of the virus.
Sakine Beygom Kazemi, Mehrnoosh Jafari, Seyed Mojtaba Hosseini, Ali Maher, Mohammad Karim Bahadori,
Volume 8, Issue 1 (3-2020)
Abstract
Background and Objective: One of the important and common applications of telemedicine is the diagnosis and treatment of skin diseases. However, teledermatology requires further commitments to provide standard services and appropriate electronic data transfer for reliable diagnostics to comply with technical standards and legal requirements. The present study aimed to determine the factors affecting the establishment of Teledermatology in the qualitative and quantitative sections .
Material and Methods: A mixed-method study (including quantitative and qualitative sections) was conducted in 2018. In the qualitative section, experts were selected by purposive sampling and the data were collected through 2 focus group discussions and 6 semi-structured interviews. The content of sessions and interviews were transcribed and then analyzed by the content analysis method. In the quantitative section, 384 participants were selected randomly. The data were collected using a researcher-made questionnaire whose validity and reliability were confirmed. Data analyses were performed in SPSS.
Results: A total of 8 categories and 58 subcategories were extracted. The 8 categories of the factors affecting the establishment of teledermatology in Iran included service provider, service recipient, structural, technological, economic, policymaking, legal, and cultural. Cultural factors (3.95±0.77) and policymaking factors (3.22±0.84), respectively, had the highest and the lowest effects on the establishment of teledermatology in Iran.
Conclusion: Factors affecting the establishment of Teledermatology are diverse and extensive, which the most effective factors were cultural factors, technological factors and factors related to service providers. These findings can help the policymakers and managers interested in the establishment of teledermatology in Iran.
Seyyed Mehdi Jafari,
Volume 8, Issue 3 (10-2020)
Abstract
Summary: Adenosine through adenosine receptor have a crucial role in biology of lung cancer. Recent study indicated adenosine receptors have a crucial role in various aspect of lung cancer from cell growth and metastasis to modulation of apoptosis and it could be considered as a potential candidate for treatment of the lung cancer.
Behboud Jafari, Abolfazl Jafari-Sales, homeira Khaneshpour, Salar Fatemi, Mehrdad Pashazadeh, Ali Esmail Al-Snafi, Afsoon Shariat,
Volume 8, Issue 3 (10-2020)
Abstract
Background and objective: In recent years, with the increase in resistance due to the indiscriminate use of synthetic antibiotics, it seems necessary to find alternative drugs that have both antibacterial properties and have the least side effects for humans. The purpose of this study is to review the antibacterial properties of some medicinal plants.
Material And Method In this review study, the content related to the antibacterial properties of Thymus vulgaris, Mentha pulegium, Crocus sativus, and Salvia officinalis were studied within Magiran, SID, PubMed, MEDLINE, Science Direct, Cochrane Library, Google Scholar, EMBASE, and Scopus databases from 1981 to 2019. Previously published specialized articles and systematic meta-analysis were used as a supplementary source for identifying relevant articles. Finally, data from 46 articles were pooled and analyzed.
Result: Extracts and essential oils of Thymus vulgaris, Mentha pulegium, Crocus sativus, and Salvia officinalis had a good antibacterial properties against a variety of pathogenic bacteria and their infections.
Conclusion: According to the results of this study, the studied plants can be considered as a suitable option for treating infections caused by pathogenic bacteria and helping to Return the sensitivity of antibiotics in these bacteria, and this requires more comprehensive research on medicinal plants.
Mahmood Poorjam, Zeinab Mohammadi, Seyyed Mehdi Jafari,
Volume 10, Issue 1 (3-2022)
Abstract
Various investigation has shown the magnitude role of adenosine receptors in cancer development. The A1, A2A, A2B, and A3 G-protein-coupled cell surface Adenosine Receptors (ARs) are found to be upregulated in many types of cancers. The adenosine receptor function has been affected by specific ligands such as agonists and/or antagonists regulated cancer (Neoplasms) cells proliferation via signaling pathways. Adenosine not only is an important intermediate metabolite but also acts as the essential ligand of adenosine receptors in physiological and pathological conditions. Furthermore, many studies have shown that adenosine receptors expression has increased in many types of cancer. In this review, we first describe adenosine's role in physiological condition and in cancer development. We further, discuss the type of adenosine receptors, distribution, expression, and their roles in cancer.
Mohammad Jafari Shiran, Saeed Naseri, Tahereh Sadeghian-Rizi, Saeed Khani, Mohammad Shoormij, Seyedeh Simin Dakhilpour,
Volume 10, Issue 2 (5-2022)
Abstract
Background and objectives: The fatty liver is a reversible form of fat accumulation in the liver cells. The burden of this disease is increasing worldwide. In general, due to the lack of proper treatment and the multiple side effects of existing chemical medicines, researchers have focused on the use of herbal medicines. The aim of this study was to evaluate the therapeutic effects of aqueous extract of Arctium lappa L. (burdock) and Cichorium intybus L. (chicory) on fatty liver in rats fed with high fat diet as respects these plants have been frequently applied in traditional medicine for treatment of the liver-related diseases.
Material and Methods: For this study, 30 Wistar rats weighing 120-220 g were used. The rats were divided into 5 groups and received 125, 250, 500 and 1000 mL/kg of mixture of aqueous extracts of burdock and chicory.
Results: Results showed that this aqueous extract reduced the liver macro-vesicles and microvesicles and symptoms of steatosis without any specific liver complications. It was found that 500 and 1000 mL/kg of extract had the most effective therapeutic effect.
Conclusion: In conclusion, our study shows that extract of burdock-chicory has the potential to ameliorate fatty liver in rats fed with high-fat diet. This study provides evidence that burdock-chicory extract could be considered as a potential dietary supplement strategy for prevention and treatment of fatty liver. Based on these results, the extract was formulated, and entered the pharmaceutical market.
Mohammad Javad Ghazanfari, Raziyeh Chaghian Arani, Amirabbas Mollaei, Aghil Mollaei, Atefeh Falakdami, Poorya Takasi, Pooyan Ghorbani Vajargah, Shaqayeq Esmaeili, Hedayat Jafari, Tahereh Yaghoubi, Samad Karkhah,
Volume 10, Issue 3 (10-2022)
Abstract
Background and Objectives: High workload, insufficient resources, and many stressors in the workplace have led to the imposition of physical and psychological pressures on nurses, which exposes them to death anxiety (DA). This systematic review aimed to assess the DA and factors associated with its in nurses during the COVID-19 pandemic.
Material and Methods: An extensive search was conducted on Scopus, PubMed, Web of Science, Iranmedex, and Scientific Information Database (SID) databases via keywords such asincluding "Death", "Death Anxiety", "Nurses", and "COVID-19", from December 2019 to November 10, 2021.
Results: 818 nurses were enrolled in four papers. The mean age and work experience of nurses Nurses’ mean age and work experiences were 31.21 (SD=5.43) and 7.60 (SD=6.73) years, respectively. The mean DA of nurses during the COVID-19 pandemic was 7.30 (SD=2.23). Also, 31.05% of nurses had a high level of DADA level during the COVID-19 pandemic. Age, sex, work experience, working hours per week, childbearing, several patients needing end‑of‑life care, direct participation in resuscitation operations, cases of direct participation in resuscitation operations, cases of patient death, depression, mental health status, and life satisfaction were influential factors in DA nurses during the COVID-19 pandemic.
Conclusion: Thus, nursing policymakers should pay special attention to these factors related to the use of nurses' health maintenance and promotion programs to increase the quality of nursing care for COVID-19 patients. Also, it is recommended that psychological and communication support be provided to nurses during the COVID-19 pandemic.
Seyyed Moein I Ebrahim, Seyyed Mehdi Jafari,
Volume 10, Issue 4 (12-2022)
Abstract
Despite significant advances in treatment, breast cancer remains a medical problem and the most common cancer leading to death among women worldwide. The most common breast cancer treatments, radiotherapy and chemotherapy are usually expensive and can cause severe side effects and low response rates due to drug resistance. To overcome these problems, medicinal plants can be the best alternative to chemotherapy drugs with fewer side effects and cost-effectiveness. Sesquiterpene lactones are compounds of the Asteraceae plant family that has significantly impacted various aspects of breast cancer cells. This review focused on the biological properties of Sesquiterpene lactones and their potential processes in breast cancer, leading to enhanced anticancer effects.
