Maryam Kazemipoor, Fatemeh Owlia, Mehri Esfandyar, Ali Dehghani, Hossein Fallahzadeh, Amir Houshang Mehrparvar, Mohammad Javad Zare Sakhvidi, Masoud Mirzaei,
Volume 7, Issue 2 (7-2019)
Abstract
Backgrounds and Objectives: Afew large population-based studies have been conducted on the prevalence of oral mucosal lesions in relation to fertility status in the Iranian population. The aim of study was determine the prevalence of oral mucosal lesions in relation to fertility status in women participants of Shahedieh cohort study.
Materials and Methods: A descriptive cross-sectional study was conducted on 4935 women who participated in the Shahedieh cohort study. The age range of participants was 35-71 years with a mean age of 47.12 years. The prevalence of oral mucosal lesions considering fertility variables including pregnancy, number of pregnancy, oophorectomy, tubectomy, hysterectomy, infertility, menopause, normal menopause, and abortion, application of infertility and oral contraceptive drugs and hormone replacement therapy were recorded.
Results: The total prevalence of oral mucosal lesions in the studied women were 3.8%. The most commonly affected age group was 40-49 years, followed by 30-39, 50-59 and 60-71 years, respectively. Considering the fertility variables, only menopause (P=0.047) and normal menopause (P=0.024) significantly related to the prevalence of oral mucosal lesions.
Conclusions: The findings of the present study provide information on the prevalence of the oral mucosal lesions considering fertility status in a large population-based study in Iran. With due attention to the higher prevalence of oral mucosal lesions in menopause women, an improved comprehension of oral manifestations at menopause and preventive and treatment approaches during this period should be programmed with health care services to meet the needs of patients deservingly.
Vahid Fallahzadeh, Farzaneh Taghian, Khosro Jalali Dehkordi,
Volume 11, Issue 3 (12-2023)
Abstract
Background: Aerobic exercise and ginger after myocardial infarction (MI) modify calcium handling. Ginger has cardioprotective effects on cardiovascular disease. This study assessed the effects of aerobic exercise combined with ginger extract (GE) loaded into chitosan nanoparticles (CNPs) on miRNA-214, Serca2a, and Anp genes and cardiac fibrosis in myocardial infarction (MI) rat models.
Methods: Twenty-five male rats divided into 5 groups were subjected to ginger treatment and exercise. Aerobic exercises (AE) were performed on a rodent treadmill 5 days per week for 6 weeks. The GE-CNPs (500 mg/kg) were orally administered to the rats for 6 weeks. The expressions of miRNA-214, Serca2a, and Anp genes were assessed by real-time polymerase chain reaction (PCR). The histopathological assessments were performed using hematoxylin and eosin (H&E) and Masson's trichrome staining. The serum activities of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) were also measured by ELISA.
Results: The MI model and CNP groups had the highest rate of collagen deposition (P <0.05). The serum activities of both CK-MB and LDH were significantly elevated in the Isop group compared to the control (P<0.05), while following aerobic exercise and ginger treatment, their activity was significantly dropped in the Isop + AE + GE-CNPs group. The expression of miRNA-214 showed a significant increase in GE-CNPs (P <0.01) and GE-CNPs + AE (P <0.001) groups. Serca2a and Anp genes showed significant changes in the GE-CNPs + AE group (P<0.05).
Conclusion: Our findings revealed that aerobic exercise, along with ginger treatment, improved cardiac fibrosis, modulating the expression levels of miRNA-214, Serca2a, and Anp genes and serum levels of MI biomarkers.
