Showing 20 results for Azar
Azar Mohammadi, Abdolhossein Taheri Kalani, Mahnaz Omidi,
Volume 0, Issue 0 (4-2024)
Abstract
Background: When metabolic demands increase due to an obesity-induced high-fat diet (HFD), mitochondrial function is impaired, production can increase, and oxidative stress occurs. This type of stress has been shown to play a key role in various pathological conditions such as heart disease, hypertension, diabetes, chronic kidney disease, and cancers. This study aims to evaluate the impact of HFD and resistance training (RT) on oxidative stress biomarkers and cardiac health in rats.
Methods: In this experimental study, 21 male Wistar rats (weighing 200-300 g) were randomly and equally assigned into the following groups: control (CTRL), HFD, and HFD+ RT. Animals in the HFD groups received a high-fat diet for 23 weeks. During the treatments, rats in the HFD+ RT group, besides receiving a high-fat diet, performed the progressive RT protocol three times per week with 30- 100% of their body mass in the last eight weeks. At the end of the treatments, superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), and malondialdehyde (MDA) levels in cardiac tissue were measured by colorimetric method. The data were analyzed by one-way analysis of variance (ANOVA) and Tukey’s post hoc test at a significant level of P<0.05.
Results: HFD did not alter levels of SOD, GPX, TAC, or MDA in cardiac tissue. Cardiac SOD (P=0.021), GPX (P=0.024), and TAC (P=0.041) levels in the HFD+ RT increased significantly compared to the HFD group, but there was no significant difference in cardiac MDA levels between the three groups (P=0.438).
Conclusion: RT seems to improve cardiac tissue oxidative stress adaptations in an animal model fed with an HFD.
Abolfazl Moghadam, Dr Shahram Nazarian,
Volume 5, Issue 2 (10-2017)
Abstract
Background & Objective: Gastroenteritis is one of the most common Salmonella infections in human which is caused by Salmonella serotypes especially S.enteritidis and S.typhimurium. The spread of multi-drug resistant (MDR) Salmonella strains is a serious global issue. Obtaining integrons is considered as one of the most important factors in multi-drug resistance among gram-negative microorganisms, particularly in intestinal bacteria. The aim of this study was to investigate the molecular level of class 1, 2 and 3 integrons which are the most important integrons in Salmonella enteritidis isolated from patients using Multiplex PCR.
Methods: In this study, 567 stool and blood samples were collected from patients with acute gastroenteritis and Salmonella enteritidis were detected using culture method, standard biochemical test, and PCR. After DNA extraction, the presence of class 1, 2, and 3 of integrons was analyzed by multiplex PCR.
Results: From 567 samples, 48 strains were identified as Salmonella enteritidis. Of all 48 strains, 45 strains (95%) had the intI gene, 7 strains (14.5%) had the intII gene, and 2 strains (4%) had the intIII gene.
Conclusion: In this study, high incidence of class 1, 2 and 3 integrons was detected. Screening integrons as a sign of obtaining and expansion of antibiotic resistance could be considered as an important mechanism to deal with antibiotic resistance in microorganisms.
Shima Kazemi Malek Mahmoudi *, Kiomars Niaz Azari, Negin Jabari,
Volume 6, Issue 2 (6-2018)
Abstract
Background & Objectives: Knowledge-based economy is one of the major parts of the resistance economy and is recognized as the essentials of the information technology age. As one of the most important educational units and the custodian of community health, universities of medical sciences play a pivotal role in the success of resistance economy based on the knowledge-based economy. Among the employees of a university, the managers and faculty members play an important role in this regard. This study aimed to explain the dimensions of the resistance economy based on the knowledge-based economy in universities of medical sciences.
Materials and Methods: This qualitative research had a purposeful sampling method. Data were collected via library and field research. In the library method, the relevant specialized scientific texts and resources were exploited, whereas in the fieldwork, the researcher interviewed 24 faculty members. The interviews continued until saturation, and after being recorded, they were transcribed in Word software, coded, classified, and encoded by Microsoft OneNote. After that, the interviews were analyzed. It is notable that ethical considerations were observed during the research process. In the field method, the texts and books were evaluated and information searched in scientific and specialized websites. In addition, relevant articles recently published in valid international journals were translated, and primary data with the topic of translation were collected. In the field research and after coordination with faculty members and main elites with a history of article or innovation production or a management background, the opinions of the interviewees were asked about some questions in a semi-structured manner. In addition, three-stage coding, open coding, axial coding, and selective coding were applied in the research. To perform open coding, the main sentences were recorded as codes, followed by classifying the similar codes. In axial coding, the classes were related to their subclasses by comparing the primary classes of open coding and revolving the ones that resembled around the common axis. In selective coding, the integration and refining process of the categories was performed to form and present the model, and the dimensions were extracted and explained.
Results: From the perspective of the faculty members and key experts, resistance economy based on knowledge-based economy in universities of medical sciences could be explained in dimensions of information and communications technology, innovation and entrepreneurship in medical sciences, human resources and knowledge-based team, administrative and structural system, resources of equipment and abilities, policy and socio-environmental impacts. Each of these dimensions also included sub-groups and special themes.
Conclusion: According to the results of the study, it could be stated that moving towards the knowledge-based economy is one of the requirements of the country on the path to economic development, which involves dimensions such as information and communications technology, innovation and entrepreneurship, specialized knowledge-generating team, strategic planning and policy-making, formulating and ensuring the legal framework and legal system, supplying and developing electronic infrastructures, and paying attention to capabilities and resources of facilities.
Razieh Nazari-Vanani, Naghmeh Sattarahmady, Negar Azarpira, Hossein Heli,
Volume 6, Issue 3 (9-2018)
Abstract
Due to low cost, ease of administration, and lack need for trained personnel, the oral route is the most convenient and accessible way to design different medicines that could be simply consumed by patients. Regardless of the great benefits of this route, the main challenge in the bioavailability of oral medications is gastrointestinal instability. Nanotechnology is used to improve the solubility and bioavailability of poorly water-soluble drugs. The self-nanoemulsifying drug delivery system is an ideal method for improving the solubility and bioavailability of poorly water-soluble drugs. This system is a sustainable combination of drugs, oils, surfactants, and cosurfactants. The combination of these components causes the nanoemulsion of oil in water with the size of droplets in the range of nm, thereby increasing the bioavailability and oral absorption of poorly water-soluble drugs. This system is highly regarded for its benefits and the ability to improve the healing properties of oral medications.
Bahareh Yazdanparast Chaharmahali, Mohammad Ali Azarbayjani, Maghsood Peeri, Parvin Farzanegi Arkhazloo,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: Elderly is characterized by decreased cardiac function, which is widely associated with mitochondrial failure in cell death. Elderly causes heart apoptosis. Although the old heart is vulnerable to apoptosis, physical training and some supplements through different mechanisms could be effective in reducing apoptosis. The present study aimed to investigate the effect of interval training on some apoptotic parameters of Bax and Bcl2 cardiomyocytes in old female rats.
Methods: In an experimental study, 49 Wistar female rats (2 years old) were randomly assigned into 7 groups: control, saline, curcumin, moderate intensity training, moderate intensity training + curcumin, high intensity training, high intensity training + curcumin. The experimental groups received gavage doses of curcumin 30 mg / kg body weight three days a week via. The saline group also received the same amount of saline. Training groups had moderate and severe exercises on the treadmill for eight weeks, and three sessions per week. Forty-eight hours after the last training session and gavage, the animals were killed and their heart tissues were isolated to determine the levels of Bax and Bcl2.
Results: The results indicated that interval training and curcumin consumption could significantly increase the levels of Bcl2 and BAX and the BAX / Bcl2 ratio, the amount of which depends on the intensity of training. Moreover, the combination of training and curcumin had an antagonistic effect.
Conclusion: According to the results, physical activity and curcumin separately have a protective effect on the heart tissue; however, these two interventions do not enhance each other’s effect. Hence each one is suggested to be used separately.
Roohollah Gholikhani, Farbod Ebadi Fard Azar, Mohammad Javad Kabir, Mohammad Mehdi Tadayon,
Volume 6, Issue 4 (12-2018)
Abstract
Background & Objctives: With regard to unclear government approach in the insurance sector, multiplicity of rules, high share of households, improper population coverage and lack of cost-effective interventions, this study aimed to analyze the current status of basic health insurance in Iran and its distance from the desirable status according to upstream documents. In addition, we attempted to propose a strategy in this regard.
Methods: This qualitative research was performed in 2017 in four stages of analysis of the current status of upstream documents and laws, round-table discussions of policy-makers, and presenting political options. In total, 20 subjects were selected by targeted sampling method with maximum diversity and based on the saturation rule. Data were collected by document analysis and interviews with authorities. Moreover, data were analyzed applying content analysis and the deductive approach.
Results: The results were classified into five areas of population coverage, financial resources management, financial protection of insured individuals, strategic purchasing, policy-making, and structure. There was a significant distance between the desirable status based on upstream documents and laws and the current status. Recommendations: eliminating conflicts of interest in decision-making areas, complying with the public interest in making health decisions, observing the principles of the evaluation of regulatory effects, and assessing the economic and social effects of health decisions.
Conclusion: Despite the successful global experiences, the recommendations of the World Health Organization, and the existence of several optimal structures, proper models must be considered by the health system of the country through observing the relevant mechanisms and necessities.
Masoud Aman Mohammadi, Mohammad Reza Rostami, Mojtaba Raeisi, Mahnaz Tabibi Azar,
Volume 6, Issue 4 (12-2018)
Abstract
Preparation of nano-microfibers from biopolymers (e.g., proteins and polysaccharides) by using electrospinning technology has been considered by researchers due to the formation of fibers or particles at the nano and micrometer scales, high porosity level, adjustable dewatering behavior, and special mechanical behavior. These products can be used in the microencapsulation of bioactive compounds, stabilization of enzymes and smart packaging. In the electrospinning method, a high voltage is used to create a nanofibers-particles. When the electric field overcomes the surface tension of the droplet, a jet exits the polymeric solution and is formed along the collector surface as it stretches toward the collector panel of the nanofiber. Parameters including molecular weight and polymer microstructure characteristics such as electrical conductivity, viscosity, surface tension, and the electrical potential applied by the device, solution flow rate, distance between the tip of the needle and the collector plate and sometimes the material of the collector plate are effective in the formation of electrospun fibers and particles. In this review, we discussed and evaluated the production stages, the strengths and weaknesses of the fibers produced from proteins and polysaccharides, and their functional properties and potentials, especially in food and drug sciences.
Dr. Mahdi Azarnoosh, Mr. Hojjat Doostdar Noghabi,
Volume 6, Issue 4 (12-2018)
Abstract
Background and objectives: The importance of continuous monitoring and rapid and accurate informing of changes in blood components (e.g., percentage of hematocrit [HCT]), especially in acute conditions, has motivated researchers to use non-invasive measurement methods. Therefore, this study aimed to evaluate the association between blood HCT and photoplethysmographic signal and the possibility of increasing the accuracy of its measurement by optical method at three specific wavelengths.
Methods: In this study, photoplethysmographic signals were recorded at three different wavelengths for 25 male and female subjects (mean age of 37.56±10.40 years), who referred to the laboratory to assess their blood HCT percentage. We extracted the peak value of the signal after calibrating a special probe with a standard pulse oximetry system and applying the necessary preprocesses on the received signal. Eventually, in addition to the estimation of HCT level, we assessed the level of correlation between the optical method results and laboratory data applying Pearson’s, Kendall’s, and Spearman’s correlation coefficients.
Results: Comparison of HCT measurement by the optical method and reference levels measured by standard laboratory technique in 25 subjects showed a mean error of 0.6±0.25%. In addition, evaluation of the relationship between data of the percentage of laboratory HCT with mean of 43.43±3.43 and data obtained by photoplethysmographic signals with mean of 43.31±3.27 by three Pearson’s, Kendall’s, and Spearman’s methods demonstrated that the data of the two techniques had a significant correlation of 0.949, 0.860, and 0.955, respectively (P<0.01).
Conclusion: Given the high correlation of characteristics of the photoplethysmographic signal at three wavelengths with blood HCT and level of accuracy of our findings, the proposed method could be exploited for accurate, clean and cost-effective monitoring of HCT level.
Leila Fozouni, Maryam Yaghoobpour, Ania Ahani Azari,
Volume 7, Issue 2 (7-2019)
Abstract
Background and objectives: Acinetobacter is a genus of opportunistic pathogens that are commonly found in the environment. Given the unique ability of these bacteria to survive in the hospital, they are considered as one of the main causes of hospital-acquired infections. The emergence of multidrug-resistant Acinetobacter spp., particularly Acinetobacter baumannii has become a major health threat worldwide. In this study, we investigate antibacterial effects of probiotic isolates from goat milk on clinical isolates of A. baumannii.
Methods: In this study, 100 clinical specimens were taken from patients hospitalized in six hospitals in the Golestan Province, north of Iran. Following isolation and identification of A. baumannii strains, antibiotic resistance patterns of the isolates were investigated using the Kirby-Bauer method according to the Clinical and Laboratory Standards Institute (CLSI-2015) guidelines. Probiotic bacteria in goat milk were isolated and identified by culture in MRS and M17 media and carbohydrate fermentation tests. Antibacterial effects of the probiotic bacteria against resistant A. baumannii isolates were evaluated using the agar well diffusion method.
Results: Overall, 55% of the isolates were identified as A. baumannii. The highest resistance rates were observed against tobramycin (76.3%), mezlocillin (74.5%) and cefotaxime (74.5%). Resistance to levofloxacin, tetracycline, imipenem and minocycline was detected in 72.7%, 72.7%, 70.9% and 29.1% of the isolates, respectively. The most common probiotic isolates were Lactobacillus plantarum and Lactococcus piscium (30% each). The highest and lowest effects were exerted by Lactococcus lactis (34.54%) and Lactobacillus bulgaricus (3.63%), respectively.
Conclusion: Our results demonstrate that the prevalence of drug-resistant A. baumannii strains is high in the hospitals. Given the promising antimicrobial effects of the isolated probiotic bacteria, goat milk can be recommended as an adjuvant therapy or an alternative to common antibiotics for improving treatment outcome of infections caused by drug-resistant A. baumannii.
Paria Motahari, Fatemeh Pournaghi Azar, Parisa Rasouly,
Volume 7, Issue 3 (9-2019)
Abstract
Background and objectives: Most studies have identified interferon-gamma (IFN-γ) as a key role in the pathogenesis of oral lichen planus (OLP). Recent studies have also shown a link between IFN-γ (+874 A/T) gene polymorphism and OLP. The purpose of the present meta-analysis is to investigate the relationship between IFN-γ (+874 A/T) gene polymorphism and susceptibility to OLP.
Methods: A systematic search of resources to investigate the association between IFN-γ and OLP from Google scholar, PubMed, Embase, Cochrane, Scopus, Proquest, Ovid and Web of science (from 2000 to April 2019) completed. Two individuals independently assessed the quality of the articles. Endnote X5 resource management software was used to organize, study titles and abstracts as well as identify duplicates. A random effect model was also used to perform the meta-analysis.
Results: Four IFN-γ (+874 A/T) polymorphism studies with 297 patients in the case group and 621 healthy controls in the 4 different countries were included. After meta-analysis, a significant association was found between IFN-γ polymorphism (+874 A/T) and OLP. (T vs A: odds ratio (OR) = 1.62; 95% CI = 1.28-2.04; TT vs AA: OR = 2.67; 95% CI = 1.6- 4.45; AT vs AA: OR = 1.56; 95% CI = 1.6- 4.45; TT vs AT + AA: OR = 1.73; 95% CI = 1.13-2.64; AT + TT vs AA: OR = 1.75; 95% CI = 1.28-2.43)
Conclusion: Based on this meta-analysis, there was a positive relationship between IFN-γ (+874 A/T) gene polymorphism and the risk of OLP. The findings showed that increasing TT genotypes significantly increased susceptibility to OLP in comparison with other genotypes.
Faegheh Jafari Amoli, Seyed Ali Hosseini, Mohammad Ali Azarbayjani, Parvin Farzanegi Arkhazloo,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objectives: It has been reported that deep-fried oils (DFOs) used in the preparation of fast foods can affect the immune system. On the other hand, regular physical activity and proper nutrition, in addition to affecting physical function, have a tremendous impact on the immune system. The aim of the present study was to investigate the anti-inflammatory effects of aerobic training (T) and octopamine (O) consumption in the heart tissue of rats fed DFO.
Methods: In this experimental study, 25 male Wistar rats with mean age of 20 weeks old and weighing 300- 350 were purchased and divided into 5 groups of 5 rats, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O and 5) DFO+T+O. During four weeks, groups 2- 5 received DFO by gavage; groups 3- 5 ran on treadmill (with speed of 50% Vo2max in the first week which reached 65% Vo2max in the last week) five sessions per week and 20 minutes per session and groups 4-5 received 81 μmol/kg octopamine supplement peritoneally for 5 days per week. Nuclear factor kappa B (NF-κB) and tumor necrosis factor-alpha (TNF-α) gene expression were measured in heart tissue.
Results: DFO significantly increased NF-κB (P=0.005) and TNF-α (P=0.001) gene expression levels; T significantly on decreased NF-κB (P=0.01) and TNF-α (P=0.007) gene expression levels; O consumption significantly decreased NF-κB (P=0.001) and TNF-α (P=0.001) gene expression levels; however, the interactive effects of T and O consumption on NF-κB (P=0.57) and TNF-α (P=0.20) gene expression levels was not significant.
Conclusion: It seems that T and O consumption alone have anti-inflammatory effects on the heart tissue of rats fed DFO, however T and O do not have anti-inflammatory interactive effects.
Mohammad Mousaei, Mohammad Ali Azarbayjani, Maghsoud Peeri, Seyed Ali Hosseini,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objectives: Controlling nutrition and exercise can be two important strategies in controlling tendon health. It has been reported that resistance training and palm pollen separately can improve Scleraxis (Scx) in tendon tissue; so present study aimed to investigate the interactive effects of resistance training with ethanolic extract of palm pollen on Scx protein and gene expression levels in the tendon tissue of male adult rats.
Methods: In this experimental study 30 male adult rats divided into 6 groups of 6 rats including: 1) sham, 2) training, 3) palm pollen, 4) testosterone, 5) training + palm pollen, and 6) training + testosterone. During 4 weeks, groups 2, 5, and 6 performed resistance trainings for five sessions per week; groups 3 and 5 received 100 mg/kg palm pollen for five days per week via gavage and groups 4 and 6 received 2 mg/kg testosterone propionate peritoneally. Scx protein and gene expression levels were measured in tendon tissue by Western blot and real-time PCR methods respectively. Shapiro- Wilk, one way ANOVA with Tukey’s post- hoc tests were used to analyze the findings (P≤0.05).
Results: Training significantly increased Scx protein levels (P=0.005); palm pollen significantly increased Scx gene expression levels (P=0.001); training + palm pollen significantly increased Scx protein and gene expression levels (P=0.001) also training + palm pollen had more favorable effect on increase of Scx protein and gene expression levels compared to training and palm pollen alone (P=0.001).
Conclusion: It seems that resistance training simultaneously with palm pollen administration can have a more favorable effect than each one alone on improving Scx protein and gene expression levels in tendon tissue of male adult rats.
Abdol Kheder Keshtvarz, Maghsoud Peeri, Mohammad Ali Azarbayjani, Seyed Ali Hosseini,
Volume 7, Issue 4 (12-2019)
Abstract
Background and objective: Exercise and nutrition are two factors influencing the improvement of inflammatory markers in patients with colon cancer. Aim of present study was to investigate the effect of aerobic training (AT) with Purslane (Portulaca Oleracea) Seed (PS) on toll like receptor 2 (TLR-2) and TLR-4 in colon tumor tissue of rats with colon cancer.
Methods: In this experimental study 30 adults rats were divided into five groups of six rats including: 1) healthy control, 2) control, 3) training, 4) PS, and 5) training + PS. Colon cancer induced by intra-peritoneal injection of azoxymethane in groups 2- 5. During eight weeks, groups 3 and 5 performed AT for five sessions per week also groups 4 and 5 received 75 mg/kg PS intra-peritoneally. TLR2 and TLR4 protein levels were measured by ELISA method. For review the normal distribution and data Shapiro- wilk was used and for statistical analysis of data one way ANOVA with Tukey’s post- hoc tests were used (P≤0.05).
Results: Training had not significant effect on TLR-2 (P=0.91) and TLR-4 (P=0.95); PS and training + PS significantly decreased TLR-2 and TLR-4 (P=0.001) also training + PS had more favorable effect on decrease of TLR-2 compare to training and PS alone (P=0.001).
Conclusion: Although PS alone can improve TLR-2 and TLR-4 levels in colon tumor tissue of adult rats with colon cancer, nevertheless it appears that AT along with PS have more favorable effects on improvement of TLR-2 compare to training and PS alone.
Sayede Shadi Nazari , Solmaz Norouzi, Mohammad Asghari Jafar-Abadi,
Volume 8, Issue 1 (3-2020)
Abstract
Background and objective: Prevalence and the spread of novel Coronavirus (2019-ncov) cause significant life and financial destruction worldwide and is the cause of severe respiratory infection in humans. The present study briefly reviews the latest information on how the virus is distributed around the world. The main question of the study are: 1- In which geographic regions of the world is the Coronavirus more concentrated? 2- Is the distribution of the Coronavirus geographically stable?
Material and Methods: To answer these questions, we first began collecting and studying the available scientific resources. The required data was obtained from a daily report of confirmed, recovered, and deaths by the Coronavirus separated by state which was collected from January 22, 2020 to Jun 19, 2020. Based on analyzing available patterns in spatial statistics tool in ArcGIS and geostatistical models, we examined how the Coronavirus was distributed around the world.
Results: The spread of the disease is increasing all over the world. Using the results of Map 1, it is seen that the spread of Corona virus has a trend and starts in China and then spreads to the Middle East, Europe and the United States in a linear manner. The results also show that the prevalence of mortality is higher than that of recovery. Central mean and median for all types (Confirmed, Recovered and death) are close to each other. Death mean and median was close to Western countries and Recovered mean and median was close to Eastern countries, while confirmed mean and median was located in the center.
Conclusion: Based on spatial statistics tool in ArcGIS and geostatistical models, we examined how the Coronavirus was distributed around the world. Our results showed that the spread of Corona virus had a trend and started in China and then spread to the Middle East, Europe and the United States in a likely linear manner.
Batol Amini Najafabadi, Saeed Keshavarz, Sedigheh Asgary, Mehrdad Azarbarzin,
Volume 8, Issue 3 (10-2020)
Abstract
Background and objective: The effect of aerobic exercise (AE) on cardiovascular (CVD) related risk factors are still debatable. Therefore this randomized controlled clinical trial (RCT) was performed with unique and specific AE protocol to investigate the effect of eight-week AE only on female subjects with type 2 diabetes.
Material And Method: A controlled RCT was performed on 30 women with type 2 diabetes aged 30 - 50. They were randomly divided into two groups, intervention and control by block randomization method. The intervention group received an incremental AE for eight weeks, three sessions per week, max heart rate (55-75%) and rating of perceived exertion (RPE) 12-13 for 150 minutes per week. Blood samples were taken before and after each intervention for both groups to be evaluated for fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile [triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C)].
Result: Eight-week AE intervention led to a significant decrease in HbA1c, FBS levels (p = 0.025, p=0.003) in experimental group compared to control however no significant differences was observed in terms of lipid profile (total cholesterol (TC), triglyceride (TG), LDL-C and HDL-C) between control and experimental group (p> 0.05). The results of paired t-test showed that FBS, TC and HbA1c levels were significantly reduced within experimental group after intervention compared to pre-test (p = 0.038, p = 0.05, p = 0.002, respectively). There was no significant difference between TG, LDL-C, and HDL-C levels within experimental group between pre and post-test (p>0.05).
Conclusion: It can be concluded that AE has been effectively reduce FBS, HbA1c and TC in women type 2 diabetes.
Somaye Pouranfar, Mohammad Ali Azarbayjani, Bahram Abedi,
Volume 8, Issue 4 (12-2020)
Abstract
Background and Objective: Reports indicate that over 60% of people with diabetes die from cardiovascular diseases. The present study was conducted to investigate the interactive effects of resistance training and genistein consumption on the serum levels of vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and C-Reactive Protein (CRP) in diabetic rats with streptozotocin.
Material And Methods: In this experimental study, 40 diabetic rats were selected and divided into 5 groups of 8 subjects, including: (1) control, (2) sham (dimethyl sulfoxide), (3) resistance training (4), genistein consumption, and (5) resistance training and genistein consumption. Rats in groups 3 and 5 received 8 weeks of resistance training, 3 sessions per week, with 30 to 100% body weight, and rats in groups 4 and 5 received 30 mg/kg of peritoneal genistein per day. Data were analyzed using independent sample t-test and two-way ANOVA in SPSS software (p≤0.05).
Results: Genistein consumption has a significant effect on reduced serum levels of VCAM and ICAM in diabetic rats (p≤0.05). Eight weeks of resistance training has a significant effect on reduced serum levels of ICAM and CRP in diabetic rats (p≤0.05). Resistance training and genistein consumption have interactive effects on reduced serum levels of VCAM and CRP in diabetic rats (p≤0.05).
Conclusion: Resistance training and genistein consumption simultaneously appear to reduce the risk of atherosclerosis in diabetic rats.
Elham Hashempour, Leila Fozouni, Ania Ahani Azari,
Volume 9, Issue 3 (10-2021)
Abstract
BBackground and Objective: Pseudomonas aeruginosa is an important case of nosocomial infections and a major health problem. The increased emergence of resistance to antibiotics and disinfectants among these bacteria, necessitates the production of new antimicrobials with wider activity and low toxicity. This study was carried out to evaluate inhibitory effects of chlorhexidine gluconate and extract of Peganum harmala on multi-drug resistant (MDR) P. aeruginosa.
Material and Methods: 39 P. aeruginosa strains were isolated from 114 environmental samples. After identifying MDR strains, minimal inhibitory concentration (MIC) of chlorhexidine gluconate (20%) and P. harmala extract against the isolates was determined by broth microdilution method.
Results: Overall, 27 (69.2%) P. aeruginosa isolates resistant to quinolones, aminoglycoside, cephems and carbapenems were reported as MDR strains. The MIC of chlorhexidine gluconate was ≥ 1000μg/ml, which was 4-fold higher than the MIC of P. harmala extract (MIC=500μg/ml). MIC of chlorhexidine gluconate and P. harmala extract against P. aeruginosa isolates differed significantly (P=0.01).
Conclusion: Compared to chlorhexidine gluconate, P. harmala extract has a higher antibacterial effect on MDR P. aeruginosa isolates from environment. Further research is required to verify the efficacy of this plant extract for disinfection of equipment in clinics and local kitchens.
Soheil Abdollahi, Mohammad Ali Azarbayjani, Maghsoud Peeri, Saleh Rahmati-Ahmadabad,
Volume 10, Issue 4 (12-2022)
Abstract
Date Palm Pollen (DDP), which is found in the male date tree, actually fertilizes the female date tree, which is necessary for the growth of date fruit. It is consisting of sugarcane, protein, calcium, vitamins (B, C and E) and minerals. It has long been used in traditional medicine as a medicinal plant with fertility effects and increased libido. The information obtained from the studies shows that this pollen, due to its antioxidant and gonadotropin-stimulating compounds, can increase fertility and sexual potency in both women and men with two main mechanisms. The first mechanism is this effect on the stimulation of gonadotrophic hormones and the second is a reduction of oxidative stress in the testicular tissue and consequently a protective effect on the testicular tissue. Due to the presence of antioxidant compounds, the consumption of this pollen also applies its health-enhancing effects to other tissues such as the liver, intestines, and heart. As same as DDP, regular Physical Activity (PA) stimulates gonadotrophic hormones and also beneficially affects antioxidant status and redox balance. In recent years, researchers have paid attention to this pollen as an important factor to strengthen the health-enhancing effects of PA, and researchers have investigated the simultaneous effect of this pollen and PA. Despite the few studies done, it seems that this pollen can enhance the antioxidant and anti-inflammatory effects of regular PAs. Nevertheless, it seems necessary to further studies in this area.
Emadoddin Moudi, Hamidreza Kamalinia, Sepehr Ramezani, Abazar Akbarzade Pasha, Omid Majidi,
Volume 11, Issue 1 (7-2023)
Abstract
This article reports a pelvic hydatid cyst in a 10-year-old boy who initially presented with right flank pain. Computed tomography (CT) revealed a cystic lesion containing internal densities, which was found to be a hydatid cyst between the bladder and rectum during surgery. The lesion was excised and sent to a pathology laboratory for further examination.
Ahmad Pourdarvish , Reza Hashemi , Jabbar Azar , Solmaz Norouzi ,
Volume 11, Issue 3 (12-2023)
Abstract
Background: In medical research and survival analysis, it is common for an individual or item's failure to be attributable to multiple causes, also known as competing risks. This article focuses on examining the competing risks model as the data increasingly becomes type II censored and randomly removed. The model assumes that the causes of failure are independent and that the lifetimes of individuals are described by the Cox model. At each failure time, the number of items or people removed follows a binomial distribution. The article derives estimators for the indefinite parameters in the model. The study presents a set of detailed data and includes a simulation study that also illustrates the results.
Methods: Different reasons, frequently known as competing risks, are frequently embroiled in an individual's or an item's failure in medical research survival analysis. The competing risks shown under sort II dynamic censoring with random removals are the subject of this research.
We get the maximum likelihood and inexact most extreme probability estimators of the obscure parameters. The asymptotic distribution of the maximum probability estimators is utilized to decide the CIs. Then, Monte Carlo simulations were applied to demonstrate the approach. The analyses were performed utilizing R 4.0.4 software.
Results: For stroke, systolic blood pressure (SBP) and hypertension status are the only significant variables. In contrast, gender, body mass index (BMI), smoking status, the logarithm of urinary albumin and creatinine ratio, and diabetes status are significant variables for coronary heart disease (CHD) and other cardiovascular diseases (CVDs). The results suggest that significant risk factors differ for different types of CVD events.
Conclusion: The outcomes of the simulation study indicate that progressively right-censored type II sampling designs outperformed the usual censored type II sampling designs. Therefore, the estimated parameters on the defined pattern setting are recommended. They can be used in many practical situations when competing risks occur, and progressive censoring could be considered.
