Jorjani Biomedicine Journal

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Background & Objective: High blood levels of IGF-1 in women before menopause, is a risk factor and P53 tumor suppressor gene is also one of the most common genes involved in breast cancer. Since some studies demonstrated that physical activity and compounds found in Celery have anti-cancer effects, this study aimed to investigate the interactive effects of eight weeks massage therapy along with celery seed supplementation on the levels of IGF-1 and P53 in overweight women. Method: In a single, blind, placebo-controlled clinical trial, the interactive effects of eight weeks massage therapy along with celery seed consumption on IGF-1 and P53 serum concentrations in overweight women were measured. For this purpose, 28 overweight women with a BMI of more than 25 kg/m2 in Ghaemshahr were randomly divided into four groups. Weight and serum levels variables of IGF-1 and P53, prior and after the therapy were measured. Then the data were analyzed using t-test and one-way variance analysis. P<0.05 was considered as the level of significance Results: At the end of the study, the average of weight and level of IGF-1 and P53 in experimental groups (massage therapy, Therapy and supplementation, Supplementation) were decreased. There was a significant difference between the weight (P=0.003), the level of IGF-1 (P <0.001) and P53 (P<0.001) of women before and after the start of the intervention in the experimental group while the control group was not changed. Conclusion: The results show that massage therapy along with celery seed supplements, especially the combination of these two non-pharmaceutical approaches have beneficial effects on body weight and IGF-1 and P53 levels in overweight women.

Keywords: Massage Therapy, Celery, IGF-1, P53

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